| Literature DB >> 3599024 |
E H Chen, K Tanabe, A J Saggiomo, E A Nodiff.
Abstract
Thirty-two 5-alkoxyprimaquines have been synthesized and evaluated as blood schizonticides (Plasmodium berghei, mouse) and tissue schizonticides (Plasmodium cynomolgi, monkey). Several of these compounds were extremely active in both screens. Such a broad spectrum of antimalarial efficacy offers the possibility of a single drug that could cure the various relapsing and nonrelapsing malarias.Entities:
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Year: 1987 PMID： 3599024 DOI： 10.1021/jm00390a012
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446