Antibody response to coronavirus disease 2019 vaccines after allergic reaction to first dose: Correspondence.

We would like to correspond on the publication, “Antibody Response to Graded Dosing of COVID-19 mRNA Vaccines After Allergic Reaction to First Dose.1” In patients hesitant to receive subsequent coronavirus disease 2019 (COVID-19) vaccine owing to a history of acute adverse reaction, Van Meerbeke et al determined that a graded dosing vaccine administration should be considered and may provide protection comparable to regular full-dose immunization. COVID-19 vaccination, in whatever dose, can provide protection and has clinical benefits, we agree. This study can provide some proof in this regard. Although, it is vital to keep in mind that confounding factors can have an impact on the immunologic parameters being measured. COVID-19 infection is widespread, and the virus can reinfect without causing symptoms. Asymptomatic COVID-19 may develop after immunization, making immunologic symptoms more difficult to diagnose. The possibility of asymptomatic COVID-19 must be ruled out to reach a conclusion.