Vinay K Thallapally1, Raahat Bansal2, Abhishek Thandra3, Sonia Gupta2, Sarah Aurit2, Venkat S Pajjuru3, Dixitha Anugula3, Aboeata Ahmed3, Joseph Nahas4. 1. Department of Medicine, Creighton University School of Medicine, 7710 Mercy Road Suite 202, Omaha, NE, 68124, USA. VinaykumarThallapally@creighton.edu. 2. Department of Medicine, Creighton University School of Medicine, 7710 Mercy Road Suite 202, Omaha, NE, 68124, USA. 3. Division of Cardiovascular Medicine, Department of Medicine, Creighton University School of Medicine, Omaha, NE, USA. 4. Division of Rheumatology, Department of Medicine, Creighton University School of Medicine, Omaha, NE, USA.
Abstract
OBJECTIVES: Rheumatoid arthritis (RA) is a systemic autoimmune disorder primarily involving the peripheral joints. Systemic involvement can occur, including myocardial dysfunction. Speckle tracking echocardiography (STE) is a novel diagnostic study which is recently being used to detect subclinical cardiac dysfunction. Global longitudinal strain (GLS) by STE is more sensitive than standard echocardiographic parameters to detect occult cardiac dysfunction. METHODS: A systematic search of PUBMED, EMBASE, Cochrane, and Google Scholar databases was performed to identify studies comparing the STE parameters between RA and non-RA patients. RESULTS: Left ventricular (LV) GLS was significantly lower in patients with RA compared to non-RA patients with a standard mean difference (SMD) of -1.09 (-1.48--0.70, P < 0.001). LV Global Circumferential Strain (GCS) was reported in five studies, and it was found to be lower in RA patients with an SMD of -1.25 (-2.59--0.10; P < 0.0010). Meta regression analysis studies failed to show any significant impact of disease duration, activity, age, sex and BMI on LV GLS and RV GLS. CONCLUSIONS: RA patients have lower LV GLS and LV GCS compared to controls suggesting impaired myocardial dysfunction. Further studies need to be done to delineate the importance of lower GLS in asymptomatic rheumatoid patients to guide disease management and risk factor modification in this selected population.
OBJECTIVES: Rheumatoid arthritis (RA) is a systemic autoimmune disorder primarily involving the peripheral joints. Systemic involvement can occur, including myocardial dysfunction. Speckle tracking echocardiography (STE) is a novel diagnostic study which is recently being used to detect subclinical cardiac dysfunction. Global longitudinal strain (GLS) by STE is more sensitive than standard echocardiographic parameters to detect occult cardiac dysfunction. METHODS: A systematic search of PUBMED, EMBASE, Cochrane, and Google Scholar databases was performed to identify studies comparing the STE parameters between RA and non-RA patients. RESULTS: Left ventricular (LV) GLS was significantly lower in patients with RA compared to non-RA patients with a standard mean difference (SMD) of -1.09 (-1.48--0.70, P < 0.001). LV Global Circumferential Strain (GCS) was reported in five studies, and it was found to be lower in RA patients with an SMD of -1.25 (-2.59--0.10; P < 0.0010). Meta regression analysis studies failed to show any significant impact of disease duration, activity, age, sex and BMI on LV GLS and RV GLS. CONCLUSIONS: RA patients have lower LV GLS and LV GCS compared to controls suggesting impaired myocardial dysfunction. Further studies need to be done to delineate the importance of lower GLS in asymptomatic rheumatoid patients to guide disease management and risk factor modification in this selected population.
Authors: Stefania L Magda; Raluca I Mincu; Maria Florescu; Andrea O Ciobanu; Gabriela F Udrea; Mircea Cinteza; Dragos Vinereanu Journal: Maedica (Bucur) Date: 2016-12
Authors: Yasemin Ozden Ayyildiz; Mustafa Gokhan Vural; Tolga Han Efe; Ahmet Goktug Ertem; Cemal Koseoglu; Mehmet Ayturk; Ekrem Yeter; Göksal Keskin; Ramazan Akdemir Journal: Hellenic J Cardiol Date: 2015 Sep-Oct
Authors: Sunita Vohra; Larissa Shamseer; Margaret Sampson; Cecilia Bukutu; Christopher H Schmid; Robyn Tate; Jane Nikles; Deborah R Zucker; Richard Kravitz; Gordon Guyatt; Douglas G Altman; David Moher Journal: BMJ Date: 2015-05-14