Pathum Sookaromdee1, Viroj Wiwanitkit2. 1. Private Academic Consultant, Bangkok, Thailand. 2. Department of Community Medicine, DY Patil University, Pune, Maharashtra, India.
We would like to share ideas on “Biological effects associated with internal and external contamination of diagnostic nuclear medicine sources: An In vitro study.[.[1]” and “DNA damages are directly associated with increasing irradiation time … contamination and related biological effects.[1]” We agree that internal exposure should be more problematic than external exposure. However, the present model might be difficult to represent an internal exposure due to its nature of in vitro and ex vivo study. All exposures in any group might be considered to get partial or total from external sources. Finally, the analytical technique, comet assay, is recognized as a highly variable investigation with the problem of reproducibility.[2] These factors should be recognized in interpretation of the present in vitro experiment.
Authors: Amaya Azqueta; Carina Ladeira; Lisa Giovannelli; Elisa Boutet-Robinet; Stefano Bonassi; Monica Neri; Goran Gajski; Susan Duthie; Cristian Del Bo'; Patrizia Riso; Gudrun Koppen; Nursen Basaran; Andrew Collins; Peter Møller Journal: Mutat Res Rev Mutat Res Date: 2019-11-09 Impact factor: 5.657