Tzu-Yu Hu1, Noor Rohmah Mayasari1, Tsai-Mu Cheng2, Chyi-Huey Bai3,4, Jane C-J Chao1,5,6, Ya-Li Huang3,4, Fan-Fen Wang7,8, Anatoly V Skalny9,10, Alexey A Tinkov9,11, Jung-Su Chang12,13,14,15. 1. School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, 250 Wu-Xing Street, Taipei, 11031, Taiwan. 2. Graduate Institute of Translational Medicine, College of Medical Sciences and Technology, Taipei Medical University, Taipei, Taiwan. 3. Department of Public Health, College of Medicine, Taipei Medical University, Taipei, Taiwan. 4. Department of Public Health, College of Public Health, Taipei Medical University, Taipei, Taiwan. 5. College of Public Health, Master Program in Global Health and Development, Taipei Medical University, Taipei, Taiwan. 6. Nutrition Research Center, Taipei Medical University Hospital, Taipei, Taiwan. 7. Department of Medicine, Yangming Branch, Taipei City Hospital, Taipei, Taiwan. 8. National Yang-Ming University School of Medicine, Taipei, Taiwan. 9. IM Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia. 10. KG Razumovsky Moscow State University of Technologies and Management, 109004, Moscow, Russia. 11. Yaroslavl State University, Yaroslavl, Russia. 12. School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, 250 Wu-Xing Street, Taipei, 11031, Taiwan. susanchang@tmu.edu.tw. 13. Nutrition Research Center, Taipei Medical University Hospital, Taipei, Taiwan. susanchang@tmu.edu.tw. 14. Graduate Institute of Metabolism and Obesity Sciences, College of Nutrition, Taipei Medical University, Taipei, Taiwan. susanchang@tmu.edu.tw. 15. Chinese Taipei Society for the Study of Obesity (CTSSO), Taipei, Taiwan. susanchang@tmu.edu.tw.
Abstract
PURPOSE: To assess whether polymorphisms of haptoglobin (Hp) modify the relationship between dietary iron and the risk of gestational iron-deficiency anemia (IDA). METHODS: This study analyzed 1430 singleton pregnant women aged 20 ~ ≤ 48 years from the 2017-2019 National Nutrition and Health Survey of Pregnant Women in Taiwan. Sociodemographic, blood biochemical, Hp phenotype, and 24-h dietary recall data were collected. Erythropoiesis-related total prenatal supplementation was defined as the reported use of multivitamins and minerals, vitamin B complex, folate, and iron. RESULTS: Distributions of the Hp 1-1, Hp 2-1, and Hp 2-2 phenotypes were 13.6, 39.8, and 46.5%, respectively. Women with the Hp 1-1 phenotype had the lowest mean levels of serum ferritin (p-trend = 0.017), the highest prevalence of gestational ID (p-trend = 0.033) as well as the highest prevalence of gestational IDA (did not reach statistical differences, p-trend = 0.086). A gene-diet interaction on serum ferritin was observed between the Hp 1 and Hp 2 (2-1/2-2) alleles (p < 0.001). An adjusted multivariate logistic regression showed that compared to those with a normal blood iron status and who reported using erythropoiesis-related total prenatal supplements, those who did not had a 4.05-fold [odds ratio (OR) = 4.05 (95% confidence interval (CI) 2.63-6.24), p < 0.001] increased risk of gestational IDA. The corresponding ORs for carriers of the Hp 1 and Hp 2 alleles were 4.78 (95% CI 1.43-15.99) and 3.79 (95% CI 2.37-6.06), respectively. CONCLUSION: Pregnant women who are Hp 1 carriers are at increased risk for developing IDA if they do not meet the recommended dietary allowance for iron or use erythropoiesis-related prenatal supplements.
PURPOSE: To assess whether polymorphisms of haptoglobin (Hp) modify the relationship between dietary iron and the risk of gestational iron-deficiency anemia (IDA). METHODS: This study analyzed 1430 singleton pregnant women aged 20 ~ ≤ 48 years from the 2017-2019 National Nutrition and Health Survey of Pregnant Women in Taiwan. Sociodemographic, blood biochemical, Hp phenotype, and 24-h dietary recall data were collected. Erythropoiesis-related total prenatal supplementation was defined as the reported use of multivitamins and minerals, vitamin B complex, folate, and iron. RESULTS: Distributions of the Hp 1-1, Hp 2-1, and Hp 2-2 phenotypes were 13.6, 39.8, and 46.5%, respectively. Women with the Hp 1-1 phenotype had the lowest mean levels of serum ferritin (p-trend = 0.017), the highest prevalence of gestational ID (p-trend = 0.033) as well as the highest prevalence of gestational IDA (did not reach statistical differences, p-trend = 0.086). A gene-diet interaction on serum ferritin was observed between the Hp 1 and Hp 2 (2-1/2-2) alleles (p < 0.001). An adjusted multivariate logistic regression showed that compared to those with a normal blood iron status and who reported using erythropoiesis-related total prenatal supplements, those who did not had a 4.05-fold [odds ratio (OR) = 4.05 (95% confidence interval (CI) 2.63-6.24), p < 0.001] increased risk of gestational IDA. The corresponding ORs for carriers of the Hp 1 and Hp 2 alleles were 4.78 (95% CI 1.43-15.99) and 3.79 (95% CI 2.37-6.06), respectively. CONCLUSION: Pregnant women who are Hp 1 carriers are at increased risk for developing IDA if they do not meet the recommended dietary allowance for iron or use erythropoiesis-related prenatal supplements.
Authors: Christian Brix Folsted Andersen; Kristian Stødkilde; Kirstine Lindhardt Sæderup; Anne Kuhlee; Stefan Raunser; Jonas H Graversen; Søren Kragh Moestrup Journal: Antioxid Redox Signal Date: 2016-11-08 Impact factor: 8.401
Authors: Ishmael Kasvosve; Victor R Gordeuk; Joris R Delanghe; Zvenyika A R Gomo; Innocent T Gangaidzo; Hlosukwazi Khumalo; Victor M Moyo; Thokozile Saungweme; Elisha Mvundura; Johan R Boelaert Journal: Clin Chem Lab Med Date: 2002-08 Impact factor: 3.694