OBJECTIVE: This study describes characteristics of large tuberculosis (TB) outbreaks in the United States detected using novel molecular surveillance methods during 2014-2016 and followed for 2 years through 2018. METHODS: We developed 4 genotype-based detection algorithms to identify large TB outbreaks of ≥10 cases related by recent transmission during a 3-year period. We used whole-genome sequencing and epidemiologic data to assess evidence of recent transmission among cases. RESULTS: There were 24 large outbreaks involving 518 cases; patients were primarily U.S.-born (85.1%) racial/ethnic minorities (84.1%). Compared with all other TB patients, patients associated with large outbreaks were more likely to report substance use, homelessness, and having been diagnosed while incarcerated. Most large outbreaks primarily occurred within residences among families and nonfamilial social contacts. A source case with a prolonged infectious period and difficulties in eliciting contacts were commonly reported contributors to transmission. CONCLUSION: Large outbreak surveillance can inform targeted interventions to decrease outbreak-associated TB morbidity. Published by Elsevier Ltd.
OBJECTIVE: This study describes characteristics of large tuberculosis (TB) outbreaks in the United States detected using novel molecular surveillance methods during 2014-2016 and followed for 2 years through 2018. METHODS: We developed 4 genotype-based detection algorithms to identify large TB outbreaks of ≥10 cases related by recent transmission during a 3-year period. We used whole-genome sequencing and epidemiologic data to assess evidence of recent transmission among cases. RESULTS: There were 24 large outbreaks involving 518 cases; patients were primarily U.S.-born (85.1%) racial/ethnic minorities (84.1%). Compared with all other TB patients, patients associated with large outbreaks were more likely to report substance use, homelessness, and having been diagnosed while incarcerated. Most large outbreaks primarily occurred within residences among families and nonfamilial social contacts. A source case with a prolonged infectious period and difficulties in eliciting contacts were commonly reported contributors to transmission. CONCLUSION: Large outbreak surveillance can inform targeted interventions to decrease outbreak-associated TB morbidity. Published by Elsevier Ltd.
Authors: Smita Ghosh; Patrick K Moonan; Lauren Cowan; Juliana Grant; Steve Kammerer; Thomas R Navin Journal: Infect Genet Evol Date: 2011-10-25 Impact factor: 3.342
Authors: Sarah M Labuda; Clinton J McDaniel; Amish Talwar; Anthwan Braumuller; Sarah Parker; Stephanie McGaha; Carolynne Blissett; Jonathan M Wortham; Leonard Mukasa; Rebekah J Stewart Journal: Public Health Rep Date: 2021-03-17 Impact factor: 2.792
Authors: Aaron C Miller; Linnea A Polgreen; Joseph E Cavanaugh; Douglas B Hornick; Philip M Polgreen Journal: Open Forum Infect Dis Date: 2015-12-19 Impact factor: 3.835