Kinetics of non-equilibrium metabolism-coupled passive transport in biosystems.

Expressions for time course of solute concentration in an arbitrary compartment of a biosystem were derived using simplifying assumptions of unidirectional transport and first order metabolism kinetics. The coefficients of the resulting exponential-summation function comprise, in addition to the volumes and the connecting areas of individual compartments, the rate parameters of the processes mentioned. The equations presented were verified using results obtained in drug potency testing.