Kelly Mesa-Gamarra1, Mario Pineda-Paternina1, Edgar Castillo2, Loida Camargo3, Alexander Pabón1, Jorge Herrera-Pino4, Nicole Caldichoury5, Pascual A Gargiulo6, Yuliana Flórez7, Norman López8. 1. Drs. Mesa-Gamarra, Pineda-Paternina, and Pabón are physicians, neurology residents with Universidad del Sinú in Cartagena, Colombia. 2. Dr. Castillo is Chief of Neurology at Universidad del Sinú in Cartagena, Colombia. 3. Dr. Camargo is a neurologist with Universidad del Sinú in Cartagena, Colombia. 4. Dr. Herrera-Pino is a physician, neuropsychologist with Medicine School, International University Florida in Miami, Florida. 5. Dr. Caldichoury is a psychologist with Universidad de Los Lagos in Osorno, Chile. 6. Dr. Gargiulo is a psychiatrist with the Laboratory of Neurosciences and Experimental Psychology, Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, CONICET in Mendoza, Argentina. 7. Dr. Flórez is a psychologist with Universidad de La Costa in Barranquilla, Colombia. 8. Dr. López is a neuropsychologist with Universidad de La Costa in Barranquilla, Colombia.
Abstract
Introduction: Recent reports have shown several cases of cerebrovascular events after vaccination against COVID-19. The effects have been described mainly in women within the first two weeks of receiving the vaccine. Clinical Case: We describe here the first Colombian case of a cerebrovascular event after vaccination against COVID-19 in a 67-year-old woman with a vascular history. Four days after application of the messenger ribonucleic acid (mRNA) vaccine, she exhibited deviation of the labial commissure, ipsilateral ptosis, and limitation of march with lateralization. The event was associated with a subacute ischemic event in the right thalamus in parasagittal situation, changes in chronic ischemic microangiopathy of small vessels, and vascular crossing in the right cerebellar angle, without other alternative causes. Conclusion: The development and rapid use of vaccines has allowed the hospitalization and mortality statistics associated with COVID-19 to be reduced, but at the same time, it has generated concern about the potential side effects, generating controversy among the general population, especially in individuals with cardiovascular diseases. In our case, we provided evidence for the discussion of potential cerebrovascular events related to the application of vaccines in older people with a history of cerebrovascular diseases. This was done in order to analyze and control in subsequent studies the modulation of medical history on the likely effects of vaccination. However, despite the unavoidable side effects, the benefits of vaccination are superior.
Introduction: Recent reports have shown several cases of cerebrovascular events after vaccination against COVID-19. The effects have been described mainly in women within the first two weeks of receiving the vaccine. Clinical Case: We describe here the first Colombian case of a cerebrovascular event after vaccination against COVID-19 in a 67-year-old woman with a vascular history. Four days after application of the messenger ribonucleic acid (mRNA) vaccine, she exhibited deviation of the labial commissure, ipsilateral ptosis, and limitation of march with lateralization. The event was associated with a subacute ischemic event in the right thalamus in parasagittal situation, changes in chronic ischemic microangiopathy of small vessels, and vascular crossing in the right cerebellar angle, without other alternative causes. Conclusion: The development and rapid use of vaccines has allowed the hospitalization and mortality statistics associated with COVID-19 to be reduced, but at the same time, it has generated concern about the potential side effects, generating controversy among the general population, especially in individuals with cardiovascular diseases. In our case, we provided evidence for the discussion of potential cerebrovascular events related to the application of vaccines in older people with a history of cerebrovascular diseases. This was done in order to analyze and control in subsequent studies the modulation of medical history on the likely effects of vaccination. However, despite the unavoidable side effects, the benefits of vaccination are superior.
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