Literature DB >> 3595853

Identification of the structures of multiple subspecies of protein kinase C expressed in rat brain.

U Kikkawa, Y Ono, K Ogita, T Fujii, Y Asaoka, K Sekiguchi, Y Kosaka, K Igarashi, Y Nishizuka.   

Abstract

Rat brain protein kinase C purified to apparent homogeneity [(1986) Biochem. Biophys. Res. Commun. 135, 636-643] was resolved into three distinct fractions, type I, II and III, upon chromatography on a hydroxyapatite column connected to high-performance liquid chromatography. Comparison of each fraction with the four subspecies of protein kinase C, that were separately expressed in COS cells transfected by the respective cDNAs, alpha, beta I, beta II and d gamma, identified the primary structures of these three fractions of protein kinase C. Type I corresponded to the enzyme encoded by the gamma-sequence; type II was a mixture of the two subspecies determined by the beta I- and beta II-sequences; and type III had the structure encoded by the alpha-sequence. The structures and properties of these subspecies of protein kinase C were similar to each other.

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Year:  1987        PMID： 3595853     DOI： 10.1016/0014-5793(87)80668-3

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  27 in total

1.  Immunocytochemical localization of the beta I subspecies of protein kinase C in rat brain.

Authors:  K Hosoda; N Saito; A Kose; A Ito; T Tsujino; K Ogita; U Kikkawa; Y Ono; K Igarashi; Y Nishizuka
Journal:  Proc Natl Acad Sci U S A       Date:  1989-02       Impact factor: 11.205

2.  Immunocytochemical localization of beta II subspecies of protein kinase C in rat brain.

Authors:  N Saito; A Kose; A Ito; K Hosoda; M Mori; M Hirata; K Ogita; U Kikkawa; Y Ono; K Igarashi
Journal:  Proc Natl Acad Sci U S A       Date:  1989-05       Impact factor: 11.205

3.  Immunocytochemical localization of the alpha subspecies of protein kinase C in rat brain.

Authors:  A Ito; N Saito; M Hirata; A Kose; T Tsujino; C Yoshihara; K Ogita; A Kishimoto; Y Nishizuka; C Tanaka
Journal:  Proc Natl Acad Sci U S A       Date:  1990-04       Impact factor: 11.205

Review 4.  Calpain and synaptic function.

Authors:  Hai-Yan Wu; David R Lynch
Journal:  Mol Neurobiol       Date:  2006-06       Impact factor: 5.590

5.  Happy birthday protein kinase C: past, present and future of a superfamily.

Authors:  Fiorenzo Battaini; Daria Mochly-Rosen
Journal:  Pharmacol Res       Date:  2007-05-18       Impact factor: 7.658

6.  Phosphatidylcholine-dependent protein kinase C activation. Effects of cis-fatty acid and diacylglycerol on synergism, autophosphorylation and Ca(2+)-dependency.

Authors:  S G Chen; D Kulju; S Halt; K Murakami
Journal:  Biochem J       Date:  1992-05-15       Impact factor: 3.857

7.  Purification of PKC-I, an endogenous protein kinase C inhibitor, and types II and III protein kinase C isoenzymes from human neutrophils.

Authors:  K J Balazovich; E L McEwen; M L Lutzke; L A Boxer; T White
Journal:  Biochem J       Date:  1992-06-01       Impact factor: 3.857

8.  Protein kinase C isozymes epsilon and alpha in murine erythroleukemia cells.

Authors:  C T Powell; L Leng; L Dong; H Kiyokawa; X Busquets; K O'Driscoll; P A Marks; R A Rifkind
Journal:  Proc Natl Acad Sci U S A       Date:  1992-01-01       Impact factor: 11.205

9.  Isolation and characterization of delta-subspecies of protein kinase C from rat brain.

Authors:  K Ogita; S Miyamoto; K Yamaguchi; H Koide; N Fujisawa; U Kikkawa; S Sahara; Y Fukami; Y Nishizuka
Journal:  Proc Natl Acad Sci U S A       Date:  1992-03-01       Impact factor: 11.205

10.  Induction of exocytosis in permeabilized pituitary cells by alpha- and beta-type protein kinase C.

Authors:  Z Naor; H Dan-Cohen; J Hermon; R Limor
Journal:  Proc Natl Acad Sci U S A       Date:  1989-06       Impact factor: 11.205
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