Kunyang Lei1, Xu Wang2, Yifu Liu1, Ting Sun1, Wenjie Xie1. 1. Department of Urology, The First Affiliated Hospital of Nanchang University Nanchang 330006, Jiangxi, China. 2. Department of Pathology, The First Affiliated Hospital of Nanchang University Nanchang 330006, Jiangxi, China.
Abstract
OBJECTIVES: To analyze the development status, research hotspots, research frontiers and future development trends of the Notch signaling pathway in cancer through bibliometric analysis. METHODS: Publications related to the Notch signaling pathway in cancer were obtained from the Web of Science Core Collection (WoSCC), and information was extracted from the articles using Microsoft Excel 2020, CiteSpace V and VOSviewer software for visual analysis. RESULTS: The country and institution with the most publications are the USA and Harvard University, respectively. PLoS One is the most published journal, and Cancer Research is the most cocited journal. The author with the most published articles was L Miele, and the most cocited author was ZW Wang. The top 3 keywords were activation, differentiation and growth. Metastasis, epithelial-mesenchymal transition (EMT), invasion, target and resistance are the current research hotspots and frontiers in this field. CONCLUSIONS: Research related to the Notch signaling pathway in cancer is currently booming, and the USA has made the greatest contribution to this field. At present, the research hotspots and research frontiers in this field mainly focus on the regulatory role of the Notch signaling pathway in tumor invasion and metastasis, the regulation of the Notch signaling pathway in tumor progression through EMT, and the participation of the Notch signaling pathway in the regulation of chemotherapy or immunotherapy resistance to tumors. AJTR
OBJECTIVES: To analyze the development status, research hotspots, research frontiers and future development trends of the Notch signaling pathway in cancer through bibliometric analysis. METHODS: Publications related to the Notch signaling pathway in cancer were obtained from the Web of Science Core Collection (WoSCC), and information was extracted from the articles using Microsoft Excel 2020, CiteSpace V and VOSviewer software for visual analysis. RESULTS: The country and institution with the most publications are the USA and Harvard University, respectively. PLoS One is the most published journal, and Cancer Research is the most cocited journal. The author with the most published articles was L Miele, and the most cocited author was ZW Wang. The top 3 keywords were activation, differentiation and growth. Metastasis, epithelial-mesenchymal transition (EMT), invasion, target and resistance are the current research hotspots and frontiers in this field. CONCLUSIONS: Research related to the Notch signaling pathway in cancer is currently booming, and the USA has made the greatest contribution to this field. At present, the research hotspots and research frontiers in this field mainly focus on the regulatory role of the Notch signaling pathway in tumor invasion and metastasis, the regulation of the Notch signaling pathway in tumor progression through EMT, and the participation of the Notch signaling pathway in the regulation of chemotherapy or immunotherapy resistance to tumors. AJTR
Authors: Jing Shan Lim; Alvaro Ibaseta; Marcus M Fischer; Belinda Cancilla; Gilbert O'Young; Sandra Cristea; Vincent C Luca; Dian Yang; Nadine S Jahchan; Cécile Hamard; Martine Antoine; Marie Wislez; Christina Kong; Jennifer Cain; Yu-Wang Liu; Ann M Kapoun; K Christopher Garcia; Timothy Hoey; Christopher L Murriel; Julien Sage Journal: Nature Date: 2017-05-10 Impact factor: 49.962
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