Literature DB >> 3595722

Reversal of acetylcholine-induced coronary resistance vessel dilation by hemoglobin.

D J Stewart, T Münzel, E Bassenge.   

Abstract

In large arteries, acetylcholine-induced dilation is mediated by endothelium-derived relaxing factor (EDRF) and can be blocked by hemoglobin (Hb). However, the role of EDRF in the microcirculation is uncertain. Therefore, the effect of Hb on acetylcholine-induced dilation of resistance vessels was studied in isolated, constant-flow perfused rabbit hearts. Hb reversibly blocked the acetylcholine-induced lowering of perfusion pressure (control -27 +/- 3%; during Hb 0 +/- 4%) without inhibiting responses to other dilators, strongly suggesting that acetylcholine action in the microcirculation is mediated by EDRF.

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Year:  1987        PMID： 3595722     DOI： 10.1016/0014-2999(87)90717-5

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  10 in total

1.  NG-nitro-L-arginine antagonizes endothelium-dependent dilator responses by inhibiting endothelium-derived relaxing factor release in the isolated rabbit heart.

Authors:  D Lamontagne; U Pohl; R Busse
Journal:  Pflugers Arch       Date:  1991-04       Impact factor: 3.657

2.  EDRF-mediated dilatation in the rat isolated perfused kidney: a microangiographic study.

Authors:  G A Burton; T M Griffith; D H Edwards
Journal:  Br J Pharmacol       Date:  1989-12       Impact factor: 8.739

3.  Removal of endothelial function in coronary resistance vessels by saponin.

Authors:  E Wiest; V Trach; J Dämmgen
Journal:  Basic Res Cardiol       Date:  1989 Sep-Oct       Impact factor: 17.165

4.  Minimal role of nitric oxide in basal coronary flow regulation and cardiac energetics of blood-perfused isolated canine heart.

Authors:  A Saeki; F A Recchia; H Senzaki; D A Kass
Journal:  J Physiol       Date:  1996-03-01       Impact factor: 5.182

5.  Role of nitric oxide in local blood flow control in the anaesthetized dog.

Authors:  M Sonntag; A Deussen; J Schrader
Journal:  Pflugers Arch       Date:  1992-02       Impact factor: 3.657

6.  Endothelium-derived relaxing factor and the effects of acetylcholine and histamine on resistance blood vessels.

Authors:  R Bhardwaj; P K Moore
Journal:  Br J Pharmacol       Date:  1988-11       Impact factor: 8.739

7.  Effects of bradykinin in the rat isolated perfused heart: role of kinin receptors and endothelium-derived relaxing factor.

Authors:  A R Baydoun; B Woodward
Journal:  Br J Pharmacol       Date:  1991-07       Impact factor: 8.739

8.  Endothelium-mediated coronary blood flow modulation in humans. Effects of age, atherosclerosis, hypercholesterolemia, and hypertension.

Authors:  A M Zeiher; H Drexler; B Saurbier; H Just
Journal:  J Clin Invest       Date:  1993-08       Impact factor: 14.808

Review 9.  Interdependence of pharmacologically-induced and endothelium-mediated coronary vasodilation in antianginal therapy.

Authors:  E Bassenge; D J Stewart
Journal:  Cardiovasc Drugs Ther       Date:  1988-05       Impact factor: 3.727

10.  Nitric oxide function in atherosclerosis.

Authors:  K E Matthys; H Bult
Journal:  Mediators Inflamm       Date:  1997       Impact factor: 4.711
  10 in total

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