Literature DB >> 3595363

Prognostic significance of clinical stage, histologic grade, and nuclear DNA content in squamous-cell carcinoma of the anus.

S Goldman, G Auer, K Erhardt, U Seligson.   

Abstract

Specimens from 47 cases of anal squamous-cell carcinoma were examined in Stockholm county (1978 to 1981) with respect to clinical stage (43 cases), histologic grade (41 cases), and DNA content of the tumor cells (31 cases). Follow-up ranged from four to seven years (median, 5.5 years). The increased mortality in advanced stage and high-grade lesions was significant. Analysis of DNA content showed that most tumors were aneuploid. No statistically significant effect of DNA content on survival could be demonstrated. Thus, histologic grade and clinical stage seem to be the best predictors of patient outcome in squamous-cell carcinoma of the anus.

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Year:  1987        PMID： 3595363     DOI： 10.1007/bf02556494

Source DB:  PubMed          Journal:  Dis Colon Rectum        ISSN： 0012-3706            Impact factor:   4.585


  10 in total

Review 1.  Anal Intraepithelial Neoplasia and Squamous Cell Cancer of the Anus.

Authors:  Rebecca E Hoedema
Journal:  Clin Colon Rectal Surg       Date:  2018-11-02

Review 2.  Anal carcinomas: the role of endoanal ultrasound and magnetic resonance imaging in staging, response evaluation and follow-up.

Authors:  Jyoti Parikh; Aidan Shaw; Lee A Grant; Alexis M P Schizas; Vivek Datta; Andrew B Williams; Nyree Griffin
Journal:  Eur Radiol       Date:  2010-10-03       Impact factor: 5.315

3.  The role of MRI in the assessment of the local status of anal carcinomas and in their management.

Authors:  É Jederán; J Lővey; Z Szentirmai; E Hitre; G Léránt; K Horváth; M Gődény
Journal:  Pathol Oncol Res       Date:  2014-10-30       Impact factor: 3.201

4.  Recurrent squamous cell carcinoma of the anal canal. Predictors of initial treatment failure and results of salvage therapy.

Authors:  W E Longo; A M Vernava; T P Wade; M A Coplin; K S Virgo; F E Johnson
Journal:  Ann Surg       Date:  1994-07       Impact factor: 12.969

Review 5.  Tumor propagating cells: drivers of tumor plasticity, heterogeneity, and recurrence.

Authors:  Alexandre Teixeira Vessoni; Eduardo Cremonese Filippi-Chiela; Guido Lenz; Luis Francisco Zirnberger Batista
Journal:  Oncogene       Date:  2019-12-04       Impact factor: 9.867

6.  Local tumor control and toxicity in HIV-associated anal carcinoma treated with radiotherapy in the era of antiretroviral therapy.

Authors:  Christoph Oehler-Jänne; Burkhardt Seifert; Urs M Lütolf; I Frank Ciernik
Journal:  Radiat Oncol       Date:  2006-08-18       Impact factor: 3.481

7.  Carcinoma of the anal canal and flow cytometric DNA analysis.

Authors:  N A Scott; R W Beart; L H Weiland; S S Cha; M M Lieber
Journal:  Br J Cancer       Date:  1989-07       Impact factor: 7.640

8.  Apparent lack of prognostic value of MIB-1 index in anal carcinomas treated by radiotherapy.

Authors:  A S Allal; L Alonso-Pentzke; S Remadi
Journal:  Br J Cancer       Date:  1998-04       Impact factor: 7.640

9.  The deubiquitinase USP15 modulates cellular redox and is a therapeutic target in acute myeloid leukemia.

Authors:  Madeline Niederkorn; Chiharu Ishikawa; Kathleen M Hueneman; James Bartram; Emily Stepanchick; Joshua R Bennett; Ashley E Culver-Cochran; Lyndsey C Bolanos; Emma Uible; Kwangmin Choi; Mark Wunderlich; John P Perentesis; Timothy M Chlon; Marie-Dominique Filippi; Daniel T Starczynowski
Journal:  Leukemia       Date:  2021-08-31       Impact factor: 11.528

10.  Current treatment options for management of anal intraepithelial neoplasia.

Authors:  Stephen E Weis
Journal:  Onco Targets Ther       Date:  2013-06-10       Impact factor: 4.147
  10 in total

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