Findings from a multi-cohort analysis indicate that levels of neutrophil extracellular trap (NET) remnants are elevated in paediatric patients affected by multi-system inflammatory syndrome in children or chilblain-like lesions (also known as ‘COVID toes’), as well as in adults with symptomatic COVID-19, and were associated with clinical outcomes. Impaired NET degradation was observed in both adult and paediatric populations; these impairments did not seem to be genetically driven and were considered to be multifactorial.
Authors: Carmelo Carmona-Rivera; Yu Zhang; Kerry Dobbs; Tovah E Markowitz; Clifton L Dalgard; Andrew J Oler; Dillon R Claybaugh; Deborah Draper; Meng Truong; Ottavia M Delmonte; Francesco Licciardi; Ugo Ramenghi; Nicoletta Crescenzio; Luisa Imberti; Alessandra Sottini; Virginia Quaresima; Chiara Fiorini; Valentina Discepolo; Andrea Lo Vecchio; Alfredo Guarino; Luca Pierri; Andrea Catzola; Andrea Biondi; Paolo Bonfanti; Maria C Poli Harlowe; Yasmin Espinosa; Camila Astudillo; Emma Rey-Jurado; Cecilia Vial; Javiera de la Cruz; Ricardo Gonzalez; Cecilia Pinera; Jacqueline W Mays; Ashley Ng; Andrew Platt; Beth Drolet; John Moon; Edward W Cowen; Heather Kenney; Sarah E Weber; Riccardo Castagnoli; Mary Magliocco; Michael A Stack; Gina Montealegre; Karyl Barron; Danielle L Fink; Douglas B Kuhns; Stephen M Hewitt; Lisa M Arkin; Daniel S Chertow; Helen C Su; Luigi D Notarangelo; Mariana J Kaplan Journal: JCI Insight Date: 2022-08-22