Miguel Rito1,2, Susana Esteves3, Isabel Fonseca4,5. 1. Serviço de Anatomia Patológica, Instituto Português de Oncologia de Lisboa, R. Prof. Lima Basto, 1099-023, Lisbon, Portugal. miguelrito@gmail.com. 2. Faculdade de Medicina, Instituto de Anatomia Patológica, Universidade de Lisboa, Lisbon, Portugal. miguelrito@gmail.com. 3. Unidade de Investigação Clínica, Instituto Português de Oncologia de Lisboa, Lisbon, Portugal. 4. Serviço de Anatomia Patológica, Instituto Português de Oncologia de Lisboa, R. Prof. Lima Basto, 1099-023, Lisbon, Portugal. 5. Faculdade de Medicina, Instituto de Anatomia Patológica, Universidade de Lisboa, Lisbon, Portugal.
Abstract
BACKGROUND: Basal cell adenoma (BCA) and adenocarcinoma (BCAd) are two of the least frequent salivary gland tumors. We describe the largest series of these neoplasms, spanning over a period of 50 years (1970-2020), diagnosed and treated in a single Institution. METHODS: Sixty-eight cases were identified. Clinical and pathological data were collected and correlated with outcome. RESULTS: Forty-one BCA and 27 BCAd were identified. BCA cases had almost pristine prognosis, with only a relapse in a tumor inadequately excised. Ten patients with BCAd developed metastases, and 14 died from the disease. The 2-year and 5-year survival was of 76% and 42%. CONCLUSIONS: The importance of adequate excision is reinforced in BCA, with no recurrences occurring when margins were negative. Contrary to previous reports, BCAd was not associated with a good prognosis. A better understanding of the genetics of these neoplasms may identify therapeutic options when dealing with inoperable or metastatic disease.
BACKGROUND: Basal cell adenoma (BCA) and adenocarcinoma (BCAd) are two of the least frequent salivary gland tumors. We describe the largest series of these neoplasms, spanning over a period of 50 years (1970-2020), diagnosed and treated in a single Institution. METHODS: Sixty-eight cases were identified. Clinical and pathological data were collected and correlated with outcome. RESULTS: Forty-one BCA and 27 BCAd were identified. BCA cases had almost pristine prognosis, with only a relapse in a tumor inadequately excised. Ten patients with BCAd developed metastases, and 14 died from the disease. The 2-year and 5-year survival was of 76% and 42%. CONCLUSIONS: The importance of adequate excision is reinforced in BCA, with no recurrences occurring when margins were negative. Contrary to previous reports, BCAd was not associated with a good prognosis. A better understanding of the genetics of these neoplasms may identify therapeutic options when dealing with inoperable or metastatic disease.
Authors: Miguel Rito; Yoshitsugu Mitani; Diana Bell; Fernanda Viviane Mariano; Salman T Almalki; Kristen B Pytynia; Isabel Fonseca; Adel K El-Naggar Journal: Mod Pathol Date: 2018-02-20 Impact factor: 7.842
Authors: Jessica L Geiger; Nofisat Ismaila; Beth Beadle; Jimmy J Caudell; Nicole Chau; Daniel Deschler; Christine Glastonbury; Marnie Kaufman; Eric Lamarre; Harold Y Lau; Lisa Licitra; Michael G Moore; Cristina Rodriguez; Anna Roshal; Raja Seethala; Paul Swiecicki; Patrick Ha Journal: J Clin Oncol Date: 2021-04-26 Impact factor: 44.544