| Literature DB >> 359459 |
J T O'Flaherty, H J Showell, P A Ward.
Abstract
Chemotactic factors transiently aggregate human polymorphonuclear neutrophils. We have found that the aggregation induced by the chemotactic tripeptide, formyl-methionyl-leucyl-phenylalanine, depends on the extracellular calcium and magnesium concentrations and is inhibited by 1 and 10 M lanthanum chloride. The ionophore A23187 and 1 and 0.1 mM lanthanum chloride aggregate the cells. A23187-induced aggregation is dependent on extracellular calcium and magnesium whereas lanthanum-induced aggregation is not.Entities:
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Year: 1978 PMID: 359459 DOI: 10.3109/08820137809025480
Source DB: PubMed Journal: Immunol Commun ISSN: 0090-0877