Muge Toprak1, Ozgul Altintas2, Hande Bickin3, Husnu Efendi4, Busra Yilmaz Tugan5, Nursen Yuksel5. 1. Ophthalmology Clinic, Gebze Fatih State Hospital, 41400, Kocaeli, Turkey. mgtoprak@hotmail.com. 2. Department of Ophthalmology, Acibadem Mehmet Ali Aydınlar University, 34398, Istanbul, Turkey. 3. Neurology Clinic, Pasaalani Private Sevgi Hospital, 10100, Balıkesir, Turkey. 4. Department of Neurology, Kocaeli University, 41100, Kocaeli, Turkey. 5. Department of Ophthalmology, Kocaeli University, 41100, Kocaeli, Turkey.
Abstract
PURPOSE: To evaluate the corneal nerve fiber morphology in patients with multiple sclerosis (MS) by in vivo corneal confocal microscopy (CCM). METHODS: Retinal nerve fiber layer thickness (RNFLT), central macular thickness (CMT), corneal nerve fiber length (CNFL), corneal nerve fiber density (CNFD), corneal nerve branch density (CNBD) and corneal nerve fiber tortuosity (CNFT) were measured. Correlation of corneal nerve findings with duration and clinical severity of MS was calculated. RESULTS: CNFL (9.50 ± 0.60 vs. 11.20 ± 0.57 mm/mm2, P = 0.046) and CNBD (57.46 ± 5.04 vs. 77.65 ± 3.41 no/mm2, P = 0.001) were significantly lower with no significant difference in CNFD (21.24 ± 1.20 vs. 23.62 ± 0.95 no/mm2, P = 0.125), CNFT (2.00 ± 0.15 vs. 1.73 ± 0.12, P = 0.180), CMT (269.57 ± 12.53 vs. 271.10 ± 18.84 μm, P = 0.716) or RNFLT (102.82 ± 6.98 vs. 105.33 ± 12.70 μm, P = 0.351) between patients with RRMS compared to controls. There was no significant correlation between CCM parameters with EDSS and duration of disease in MS patients. CONCLUSION: The current study demonstrated that a decrease in CNFL, CNFD and CNBD in CCM analysis in the early course of MS.
PURPOSE: To evaluate the corneal nerve fiber morphology in patients with multiple sclerosis (MS) by in vivo corneal confocal microscopy (CCM). METHODS: Retinal nerve fiber layer thickness (RNFLT), central macular thickness (CMT), corneal nerve fiber length (CNFL), corneal nerve fiber density (CNFD), corneal nerve branch density (CNBD) and corneal nerve fiber tortuosity (CNFT) were measured. Correlation of corneal nerve findings with duration and clinical severity of MS was calculated. RESULTS: CNFL (9.50 ± 0.60 vs. 11.20 ± 0.57 mm/mm2, P = 0.046) and CNBD (57.46 ± 5.04 vs. 77.65 ± 3.41 no/mm2, P = 0.001) were significantly lower with no significant difference in CNFD (21.24 ± 1.20 vs. 23.62 ± 0.95 no/mm2, P = 0.125), CNFT (2.00 ± 0.15 vs. 1.73 ± 0.12, P = 0.180), CMT (269.57 ± 12.53 vs. 271.10 ± 18.84 μm, P = 0.716) or RNFLT (102.82 ± 6.98 vs. 105.33 ± 12.70 μm, P = 0.351) between patients with RRMS compared to controls. There was no significant correlation between CCM parameters with EDSS and duration of disease in MS patients. CONCLUSION: The current study demonstrated that a decrease in CNFL, CNFD and CNBD in CCM analysis in the early course of MS.
Authors: Ioannis N Petropoulos; Georgios Ponirakis; Adnan Khan; Hoda Gad; Hamad Almuhannadi; Michael Brines; Anthony Cerami; Rayaz A Malik Journal: Clin Exp Optom Date: 2019-03-04 Impact factor: 2.742
Authors: F Gemignani; G Ferrari; F Vitetta; M Giovanelli; C Macaluso; A Marbini Journal: J Neurol Neurosurg Psychiatry Date: 2010-07 Impact factor: 10.154
Authors: Mitra Tavakoli; Andrew Marshall; Robert Pitceathly; Hassan Fadavi; David Gow; Mark E Roberts; Nathan Efron; Andrew Jm Boulton; Rayaz A Malik Journal: Exp Neurol Date: 2009-09-11 Impact factor: 5.330