Jehier Afifi1, Prakesh S Shah2,3, Xiang Y Ye2, Vibhuti Shah3, Bruno Piedboeuf4, Keith Barrington5, Edmond Kelly3, Walid El-Naggar6. 1. Department of Pediatrics, IWK Health Centre and Dalhousie University, Halifax, NS, Canada. jehier.afifi@iwk.nshealth.ca. 2. Maternal-infant Care Research Centre, Mount Sinai Hospital, Toronto, ON, Canada. 3. Departments of Pediatrics, Mount Sinai Hospital and University of Toronto, Toronto, ON, Canada. 4. Department of Pediatrics, CHU de Québec-Université Laval, Québec, QC, Canada. 5. Department of Pediatrics, CHU Sainte Justine, Québec, QC, Canada. 6. Department of Pediatrics, IWK Health Centre and Dalhousie University, Halifax, NS, Canada.
Abstract
OBJECTIVE: To describe the incidence, trends, management's variability and short-term outcomes of preterm infants with severe post-hemorrhagic ventricular dilatation (sPHVD). METHODS: We reviewed infants <33 weeks' gestation who had PHVD and were admitted to the Canadian Neonatal Network between 2010 and 2018. We compared perinatal characteristics and short-term outcomes between those with sPHVD and those with mild/moderate PHVD and those with and without ventriculo-peritoneal (VP) shunt. RESULTS: Of 29,417 infants, 2439 (8%) had PHVD; rate increased from 7.3% in 2010 to 9.6% in 2018 (P = 0.005). Among infants with PHVD, sPHVD (19%) and VP shunt (29%) rates varied significantly across Canadian centers and between geographic regions (P < 0.01 and P = 0.0002). On multivariable analysis, sPHVD was associated with greater mortality, seizures and meningitis compared to mild/moderate PHVD. CONCLUSIONS: Significant variability in sPHVD and VP shunt rates exists between centers and regions in Canada. sPHVD was associated with increased mortality and morbidities.
OBJECTIVE: To describe the incidence, trends, management's variability and short-term outcomes of preterm infants with severe post-hemorrhagic ventricular dilatation (sPHVD). METHODS: We reviewed infants <33 weeks' gestation who had PHVD and were admitted to the Canadian Neonatal Network between 2010 and 2018. We compared perinatal characteristics and short-term outcomes between those with sPHVD and those with mild/moderate PHVD and those with and without ventriculo-peritoneal (VP) shunt. RESULTS: Of 29,417 infants, 2439 (8%) had PHVD; rate increased from 7.3% in 2010 to 9.6% in 2018 (P = 0.005). Among infants with PHVD, sPHVD (19%) and VP shunt (29%) rates varied significantly across Canadian centers and between geographic regions (P < 0.01 and P = 0.0002). On multivariable analysis, sPHVD was associated with greater mortality, seizures and meningitis compared to mild/moderate PHVD. CONCLUSIONS: Significant variability in sPHVD and VP shunt rates exists between centers and regions in Canada. sPHVD was associated with increased mortality and morbidities.
Authors: Jay Riva-Cambrin; Chevis N Shannon; Richard Holubkov; William E Whitehead; Abhaya V Kulkarni; James Drake; Tamara D Simon; Samuel R Browd; John R W Kestle; John C Wellons Journal: J Neurosurg Pediatr Date: 2012-05 Impact factor: 2.375
Authors: Anne R Synnes; Ying C Macnab; Zhenguo Qiu; Arne Ohlsson; Paul Gustafson; Charmaine B Dean; Shoo K Lee Journal: Med Care Date: 2006-08 Impact factor: 2.983
Authors: Kei Lui; Shoo K Lee; Satoshi Kusuda; Mark Adams; Maximo Vento; Brian Reichman; Brian A Darlow; Liisa Lehtonen; Neena Modi; Mikael Norman; Stellan Håkansson; Dirk Bassler; Franca Rusconi; Abhay Lodha; Junmin Yang; Prakesh S Shah Journal: J Pediatr Date: 2019-10-03 Impact factor: 4.406
Authors: Eisha A Christian; Diana L Jin; Frank Attenello; Timothy Wen; Steven Cen; William J Mack; Mark D Krieger; J Gordon McComb Journal: J Neurosurg Pediatr Date: 2015-11-06 Impact factor: 2.375
Authors: Prakesh S Shah; Kei Lui; Gunnar Sjörs; Lucia Mirea; Brian Reichman; Mark Adams; Neena Modi; Brian A Darlow; Satoshi Kusuda; Laura San Feliciano; Junmin Yang; Stellan Håkansson; Rintaro Mori; Dirk Bassler; Josep Figueras-Aloy; Shoo K Lee Journal: J Pediatr Date: 2016-05-24 Impact factor: 4.406