Adam D Seal1, Abigail T Colburn2, Evan C Johnson3, François Péronnet4, Lisa T Jansen5, J D Adams6, Costas N Bardis7, Isabelle Guelinckx8, Erica T Perrier8, Stavros A Kavouras9. 1. Department of Kinesiology and Public Health, California Polytechnic State University, San Luis Obispo, CA, USA. 2. Hydration Science Lab, Arizona State University, College of Health Solutions, Phoenix, AZ, USA. 3. Human Integrated Physiology Laboratory, University of Wyoming, Laramie, WY, USA. 4. École de Kinésiologie et des Sciences de l'Activité Physique, University of Montreal, Montreal, QC, Canada. 5. Department of Dietetics and Nutrition, University of Arkansas for Medical Sciences, Little Rock, AR, USA. 6. Department of Health and Human Performance, College of Charleston, Charleston, SC, USA. 7. Section of Sports Medicine and Biology of Physical Activity, School of Physical Education and Sport Science, University of Athens, Athens, Greece. 8. Danone Research, Palaiseau, France. 9. Hydration Science Lab, Arizona State University, College of Health Solutions, Phoenix, AZ, USA. stavros.kavouras@asu.edu.
Abstract
PURPOSE: Recent studies suggest that 24-h urine osmolality (UOsm) for optimal water intake should be maintained < 500 mmol·kg-1. The purpose of this study was to determine the total water intake (TWI) requirement for healthy adults to maintain optimal hydration as indicated by 24-h urine osmolality < 500 mmol·kg-1. METHODS: Twenty-four-hour UOsm was assessed in 49 men and 50 women residing in the United States (age: 41 ± 14 y, body mass index: 26.3 ± 5.2 kg·m-2). TWI was assessed from 7-day water turnover, using a dilution of deuterium oxide, corrected for metabolic water production. The diagnostic accuracy of TWI to identify UOsm < 500 mmol·kg-1 was evaluated using receiver operating characteristic (ROC) analysis in men and women separately. RESULTS: Twenty-four-hour UOsm was 482 ± 229 and 346 ± 182 mmol·kg-1 and TWI was 3.57 ± 1.10 L·d-1 and 3.20 ± 1.27 L·d-1 in men and women, respectively. ROC analysis for TWI detecting 24-h UOsm < 500 mmol·kg-1 in men yielded an area under the curve (AUC) of 77.4% with sensitivity, specificity, and threshold values of 83.3%, 64.5%, and 3.39 L·d-1, respectively. The AUC was 82.4% in women with sensitivity, specificity, and threshold values of 85.7%, 72.1%, and 2.61 L·d-1. CONCLUSION: Considering threshold values in men and women of 3.4 L·d-1 and 2.6 L·d-1, respectively, maintaining TWI in line with National Academy of Medicine guidelines of 3.7 L·d-1 in men and 2.7 L·d-1 in women should be sufficient for most individuals in the United States to maintain 24-h UOsm < 500 mmol·kg-1.
PURPOSE: Recent studies suggest that 24-h urine osmolality (UOsm) for optimal water intake should be maintained < 500 mmol·kg-1. The purpose of this study was to determine the total water intake (TWI) requirement for healthy adults to maintain optimal hydration as indicated by 24-h urine osmolality < 500 mmol·kg-1. METHODS: Twenty-four-hour UOsm was assessed in 49 men and 50 women residing in the United States (age: 41 ± 14 y, body mass index: 26.3 ± 5.2 kg·m-2). TWI was assessed from 7-day water turnover, using a dilution of deuterium oxide, corrected for metabolic water production. The diagnostic accuracy of TWI to identify UOsm < 500 mmol·kg-1 was evaluated using receiver operating characteristic (ROC) analysis in men and women separately. RESULTS: Twenty-four-hour UOsm was 482 ± 229 and 346 ± 182 mmol·kg-1 and TWI was 3.57 ± 1.10 L·d-1 and 3.20 ± 1.27 L·d-1 in men and women, respectively. ROC analysis for TWI detecting 24-h UOsm < 500 mmol·kg-1 in men yielded an area under the curve (AUC) of 77.4% with sensitivity, specificity, and threshold values of 83.3%, 64.5%, and 3.39 L·d-1, respectively. The AUC was 82.4% in women with sensitivity, specificity, and threshold values of 85.7%, 72.1%, and 2.61 L·d-1. CONCLUSION: Considering threshold values in men and women of 3.4 L·d-1 and 2.6 L·d-1, respectively, maintaining TWI in line with National Academy of Medicine guidelines of 3.7 L·d-1 in men and 2.7 L·d-1 in women should be sufficient for most individuals in the United States to maintain 24-h UOsm < 500 mmol·kg-1.
Authors: William F Clark; Jessica M Sontrop; Jennifer J Macnab; Rita S Suri; Louise Moist; Marina Salvadori; Amit X Garg Journal: Clin J Am Soc Nephrol Date: 2011-09-01 Impact factor: 8.237
Authors: Evan C Johnson; Colleen X Muñoz; Laurent Le Bellego; Alexis Klein; Douglas J Casa; Carl M Maresh; Lawrence E Armstrong Journal: Eur J Appl Physiol Date: 2015-01-07 Impact factor: 3.078
Authors: Evan C Johnson; François Péronnet; Lisa T Jansen; Catalina Capitan-Jiménez; J D Adams; Isabelle Guelinckx; Liliana Jiménez; Andy Mauromoustakos; Stavros A Kavouras Journal: J Nutr Date: 2017-09-06 Impact factor: 4.798
Authors: Aarthi Raman; Dale A Schoeller; Amy F Subar; Richard P Troiano; Arthur Schatzkin; Tamara Harris; Douglas Bauer; Shiela A Bingham; James E Everhart; Anne B Newman; Frances A Tylavsky Journal: Am J Physiol Renal Physiol Date: 2003-11-04
Authors: Erica T Perrier; Inmaculada Buendia-Jimenez; Mariacristina Vecchio; Lawrence E Armstrong; Ivan Tack; Alexis Klein Journal: Dis Markers Date: 2015-03-18 Impact factor: 3.434