| Literature DB >> 3594219 |
P A Brooks, J S Kelly, J M Allen, D A Smith, T W Stone.
Abstract
Intracellular recordings from granule cells of the rat dentate gyrus show neuropeptide Y (NPY) applied by pressure ejection from pipettes containing 1.2-12 microM by pressures of less than 200 kPa for 1-5 s in duration to consistently evoke membrane depolarisations accompanied by a reduction in membrane resistance. The depolarisations were accompanied by an increase in excitability. Since the depolarisations evoked by NPY were not attenuated by either tetrodotoxin or kynurenic acid a direct excitatory action of NPY is postulated.Entities:
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Year: 1987 PMID： 3594219 DOI： 10.1016/0006-8993(87)90391-x
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252