Literature DB >> 35941268

Mechanisms involved in hematopoietic stem cell aging.

Takeshi Fujino1, Shuhei Asada2, Susumu Goyama3, Toshio Kitamura4.   

Abstract

Hematopoietic stem cells (HSCs) undergo progressive functional decline over time due to both internal and external stressors, leading to aging of the hematopoietic system. A comprehensive understanding of the molecular mechanisms underlying HSC aging will be valuable in developing novel therapies for HSC rejuvenation and to prevent the onset of several age-associated diseases and hematological malignancies. This review considers the general causes of HSC aging that range from cell-intrinsic factors to cell-extrinsic factors. In particular, epigenetics and inflammation have been implicated in the linkage of HSC aging, clonality, and oncogenesis. The challenges in clarifying mechanisms of HSC aging have accelerated the development of therapeutic interventions to rejuvenate HSCs, the major goal of aging research; these details are also discussed in this review.
© 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.

Entities:  

Keywords:  Aging; Clonal hematopoiesis; Hematological malignancy; Hematopoietic stem cell; Rejuvenation

Mesh：

Year:  2022        PMID： 35941268     DOI： 10.1007/s00018-022-04356-5

Source DB:  PubMed          Journal:  Cell Mol Life Sci        ISSN： 1420-682X            Impact factor:   9.207


  248 in total

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Journal:  Blood       Date:  2017-04-19       Impact factor: 22.113

4.  Progeria: a paradigm for translational medicine.

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Journal:  Cell       Date:  2014-01-30       Impact factor: 41.582

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Journal:  N Engl J Med       Date:  2014-11-26       Impact factor: 91.245

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Journal:  N Engl J Med       Date:  2014-11-26       Impact factor: 91.245

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Journal:  Nature       Date:  1990-05-31       Impact factor: 49.962

8.  Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia.

Authors:  Jack M Guralnik; Richard S Eisenstaedt; Luigi Ferrucci; Harvey G Klein; Richard C Woodman
Journal:  Blood       Date:  2004-07-06       Impact factor: 22.113

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Authors:  Mingchao Xie; Charles Lu; Jiayin Wang; Michael D McLellan; Kimberly J Johnson; Michael C Wendl; Joshua F McMichael; Heather K Schmidt; Venkata Yellapantula; Christopher A Miller; Bradley A Ozenberger; John S Welch; Daniel C Link; Matthew J Walter; Elaine R Mardis; John F Dipersio; Feng Chen; Richard K Wilson; Timothy J Ley; Li Ding
Journal:  Nat Med       Date:  2014-10-19       Impact factor: 53.440

10.  Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease.

Authors:  Siddhartha Jaiswal; Pradeep Natarajan; Alexander J Silver; Christopher J Gibson; Alexander G Bick; Eugenia Shvartz; Marie McConkey; Namrata Gupta; Stacey Gabriel; Diego Ardissino; Usman Baber; Roxana Mehran; Valentin Fuster; John Danesh; Philippe Frossard; Danish Saleheen; Olle Melander; Galina K Sukhova; Donna Neuberg; Peter Libby; Sekar Kathiresan; Benjamin L Ebert
Journal:  N Engl J Med       Date:  2017-06-21       Impact factor: 91.245
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