Literature DB >> 359396

Intracellular pancreatic B cell serotonin and the dynamics of insulin release.

O M Pulido, S A Bencosme, M L de Bold, A J de Bold.   

Abstract

The role of intracellular pancreatic B cell serotonin in the dynamics of insulin release was investigated in an in situ perfused rat pancreas preparation. Animals were pretreated with 5-hydroxytryptophan (5-HTP) to increase the intracellular levels of serotonin (5-HT) as shown by fluorescence histochemistry. Despite a clear induction of intracellular 5-HT fluorescence in pancreatic islets neither the pattern nor the total amount of insulin released were significantly modified after perfusion with either glucose or tolbutamide. However, the L-amino acid decarboxylase inhibitor, RO 4--4602, significantly decreased both phases of glucose-mediated insulin release in normal animals as well as in those receiving 5-HTP.

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Year:  1978        PMID： 359396     DOI： 10.1007/bf00421239

Source DB:  PubMed          Journal:  Diabetologia        ISSN： 0012-186X            Impact factor:   10.122


  26 in total

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Authors:  A E Pontiroli; G C Viberti; A Tognetti; G Pozza
Journal:  Diabetologia       Date:  1975-04       Impact factor: 10.122

Review 2.  Neuropharmacology of the pancreatic islets.

Authors:  P H Smith; D Porte
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3.  Potentiation of insulin secretion in vitro by serotonin antagonists.

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4.  A serotoninergic mechanism for the control of insulin secretion.

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Journal:  Trans Assoc Am Physicians       Date:  1972

5.  Pancreatic biogenic amines and insulin secretion in health and disease.

Authors:  H E Lebovitz; J M Feldman
Journal:  Fed Proc       Date:  1973-07

6.  Dynamics of insulin secretion by the perfused rat pancreas.

Authors:  D L Curry; L L Bennett; G M Grodsky
Journal:  Endocrinology       Date:  1968-09       Impact factor: 4.736

7.  Antagonism of catecholamine inhibition of insulin secretion by methysergide.

Authors:  J M Feldman; H E Lebovitz
Journal:  Experientia       Date:  1972-04-15

8.  Ultrastructural changes in B cells of pancreatic islets from rats with elevated levels of circulating growth hormone secreted by MtT-W15 tumor.

Authors:  S A Bencosme; V Tsutsumi; J M Martin; H K Akerblom
Journal:  Diabetes       Date:  1971-01       Impact factor: 9.461

9.  Beta cell monoamines: further evidence for their role in modulating insulin secretion.

Authors:  J P Wilson; R W Downs; J M Feldman; H E Lebovitz
Journal:  Am J Physiol       Date:  1974-08

10.  The significance of 5-hydroxytryptamine for insulin secretion in the mouse.

Authors:  A Lernmark
Journal:  Horm Metab Res       Date:  1971-09       Impact factor: 2.936
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  3 in total

1.  Immunohistochemical colocalization of glucagon, serotonin, and aromatic L-amino acid decarboxylase in islet A cells of chicken pancreas.

Authors:  T Watanabe; T Morikami; I Nagatsu
Journal:  Cell Tissue Res       Date:  1990-01       Impact factor: 5.249

2.  Immunohistochemical colocalization of insulin, aromatic L-amino acid decarboxylase and dopamine beta-hydroxylase in islet B cells of chicken pancreas.

Authors:  T Watanabe; I Nagatsu
Journal:  Cell Tissue Res       Date:  1991-01       Impact factor: 5.249

3.  Structural basis of RNA polymerase I pre-initiation complex formation and promoter melting.

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Journal:  Nat Commun       Date:  2020-03-05       Impact factor: 14.919
  3 in total

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