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Literature DB >> 3593904

Pharmacokinetics of flurbiprofen in man. I. Area/dose relationships.

G J Szpunar, K S Albert, G G Bole, J N Dreyfus, G F Lockwood, J G Wagner.

Abstract

Flurbiprofen pharmacokinetics were studied in 15 normal male subjects after four oral doses. Plasma levels of total (bound + free) drug were monitored for 48 h and urine was collected for 96 h after the doses. All subjects demonstrated linear relationships between administered dose and total flurbiprofen AUC, indicating that oral clearance is independent of dose for the dose range evaluated in this study. Urinary recovery data indicated that the efficacy of absorption was dose independent.

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Year: 1987 PMID： 3593904 DOI： 10.1002/bdd.2510080308

Source DB: PubMed Journal: Biopharm Drug Dispos ISSN： 0142-2782 Impact factor: 1.627

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Cited

15 in total

1. Elucidating the role of dose in the biopharmaceutics classification of drugs: the concepts of critical dose, effective in vivo solubility, and dose-dependent BCS.

Authors: Georgia Charkoftaki; Aristides Dokoumetzidis; Georgia Valsami; Panos Macheras
Journal: Pharm Res Date: 2012-07-04 Impact factor: 4.200

2. Pharmacokinetic parameters of (R)-(-) and (S)-(+)-flurbiprofen in dairy bovines.

Authors: L Igarza; A Soraci; N Auza; H Zeballos
Journal: Vet Res Commun Date: 2006-07 Impact factor: 2.459

3. Stepwise determination of multicompartment disposition and absorption parameters from extravascular concentration-time data. Application to mesoridazine, flurbiprofen, flunarizine, labetalol, and diazepam.

Authors: J G Wagner; D A Ganes; K K Midha; I Gonzalez-Younes; J C Sackellares; L D Olson; M B Affrime; J E Patrick
Journal: J Pharmacokinet Biopharm Date: 1991-08

Pharmacokinetics of flurbiprofen in man. I. Area/dose relationships.

1. Elucidating the role of dose in the biopharmaceutics classification of drugs: the concepts of critical dose, effective in vivo solubility, and dose-dependent BCS.

2. Pharmacokinetic parameters of (R)-(-) and (S)-(+)-flurbiprofen in dairy bovines.

3. Stepwise determination of multicompartment disposition and absorption parameters from extravascular concentration-time data. Application to mesoridazine, flurbiprofen, flunarizine, labetalol, and diazepam.

4. Stereoselective disposition of flurbiprofen in uraemic patients.

5. Stereoselective disposition of flurbiprofen in normal volunteers.

6. Serum protein binding of nonsteroidal antiinflammatory drugs: a comparative study.

7. Evaluation of flurbiprofen urinary ratios as in vivo indices for CYP2C9 activity.

8. Plasma and cerebrospinal fluid pharmacokinetics of flurbiprofen in children.

9. Absorption of flurbiprofen in the fed and fasted states.

Review 10. Clinical pharmacokinetics of flurbiprofen and its enantiomers.