Literature DB >> 35938362

Surgical Outcomes of Patients Undergoing Gastrectomy for Gastric Cancer: Does the Age Matter?

Bang Wool Eom1.   

Abstract

Entities:  

Year:  2022        PMID: 35938362      PMCID: PMC9359883          DOI: 10.5230/jgc.2022.22.e20

Source DB:  PubMed          Journal:  J Gastric Cancer        ISSN: 1598-1320            Impact factor:   3.197


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As life expectancy increases and rapid aging of the population continues to occur over the last decades, the number of elderly patients requiring treatment has also increased [1]. Gastric cancer mainly occurs in older patients, with most patients being 60 or higher, and the proportion of gastric cancer patients over 70 years old is increasing [2]. This increasing trend has resulted in an increase in elderly patients requiring radical gastrectomy. In this issue of the Journal of Gastric Cancer, Park et al. [3] analyzed data from the Korea Central Cancer Registry to demonstrate the changes in the incidence and demographics of gastric cancer from 1999 to 2019. The Korean Central Registry includes information on cancer in the entire Korean population using the data of more than 150 training hospitals [4]. As such, this study is the most recent study showing all gastric cancer data in Korea over the longest period of time, therefore presenting meaningful information. Among the several changes over the past 20 years shown in this study, one notable result is that the proportion of patients over 70 years of age has increased from 29% to 37%. In other words, more than one-third of patients with gastric cancer are over 70 years of age. Considering that this trend may be further exacerbated in the future, it is imperative to put more effort into ensuring that the radical gastrectomy for elderly gastric cancer patients is both rational and beneficial. Regarding the surgical outcomes of the elderly, many studies have reported no significant difference in postoperative complications and mortality between the elderly and non-elderly patients [56789]. Conversely, some studies have shown an increased incidence of severe complications in the elderly, but statistically insignificant difference in postoperative mortality [101112]. Other studies have demonstrated worse outcomes of the elderly in both postoperative complications and mortality [1314]. The study by Lee at al. [15] is one that showed worse outcomes in the elderly. The authors analyzed the surgical outcomes of the elderly based on the National Inpatient Sample (NIS) data and identified higher in-hospital mortality rates in septuagenarians and octogenarians than in patients under 60 years of age. The validity of this study is strengthened by its use of a large-scale database, however, data regarding postoperative complications is limited and long-term data is lacking. Several studies have indicated that that the postoperative complication rate depends greatly on the number and severity of pre-existing diseases [1617]. The elderly have a significantly higher number of medical comorbidities and are vulnerable to postoperative medical problems such as pneumonia. Postoperative complications in the elderly lead to a significant increase in costs, length of hospital stay, and patient distress and suffering. Limitations in daily life and family burdens should also not be neglected. Therefore, in view of the risk of postoperative complications, elderly patients should receive special attention. Precise risk assessment prior to surgery is also necessary, as this would aid clinicians in anticipating and dealing with complications, reducing postoperative mortality, and improving quality of care [18]. Recently, a guideline for the management of elderly patients with early gastric cancer was reported in Japan [19]. In the analysis using the nationwide data, relatively low overall survival and non-negligible postoperative 90-day mortality rates were observed, and 20% or more old patients reportedly died within 5 years after gastrectomy, mostly due to other diseases. These suggest the necessity for a less invasive treatment option and a non-invasive follow-up option for the elderly patients with a poor general condition. New indications for endoscopic submucosal dissection were also considered to avoid overtreatment with gastrectomy. Thus, flexible approaches for elderly patients should be performed in the future. Moreover, reduced treatment that goes against oncological principles for the elderly with good general condition should also be avoided. Personalized risk assessment, rationale based on evidence, and comprehensive understanding of the function and quality of life of the elderly should take precedence over age itself.
  17 in total

1.  The safety and feasibility of laparoscopic gastrectomy for gastric cancer in very elderly patients: short-and long-term outcomes.

Authors:  Ryuichi Mikami; Eiji Tanaka; Teppei Murakami; Satoshi Ishida; Yugo Matsui; Kenta Horita; Masaki Yamada; Takashi Nitta; Masahiro Mise; Takehisa Harada; Masahiko Takeo; Shigeki Arii
Journal:  Surg Today       Date:  2020-07-16       Impact factor: 2.549

2.  Preoperative Cardiac Risk Assessment and Surgical Outcomes of Patients with Gastric Cancer.

Authors:  Sohei Matsumoto; Tomoyoshi Takayama; Kohei Wakatsuki; Tetsuya Tanaka; Kazuhiro Migita; Masahiro Ito; Hiroshi Nakade; Tomohiro Kunishige; Yoshiyuki Nakajima
Journal:  Ann Surg Oncol       Date:  2015-03-06       Impact factor: 5.344

3.  Surgical outcomes and survival after gastrectomy in octogenarians with gastric cancer.

Authors:  Ji-Hyun Kim; Hyung-Min Chin; Kyong-Hwa Jun
Journal:  J Surg Res       Date:  2015-05-29       Impact factor: 2.192

4.  Surgical treatment for gastric carcinoma in the elderly.

Authors:  Arianna Coniglio; Guido Alberto Massimo Tiberio; Monica Busti; Giacomo Gaverini; Luca Baiocchi; Tullio Piardi; Maurizio Ronconi; Stefano Maria Giulini
Journal:  J Surg Oncol       Date:  2004-12-15       Impact factor: 3.454

5.  Comparison of surgical outcomes of gastric cancer in elderly and middle-aged patients.

Authors:  Chikara Kunisaki; Hirotoshi Akiyama; Masato Nomura; Goro Matsuda; Yuichi Otsuka; Hidetaka Andrew Ono; Hiroshi Shimada
Journal:  Am J Surg       Date:  2006-02       Impact factor: 2.565

6.  Laparoscopy-assisted gastrectomy for early gastric cancer in young and elderly patients.

Authors:  Erito Mochiki; Testsurou Ohno; Youichi Kamiyama; Rusuke Aihara; Toshihiro Nakabayashi; Takayuki Asao; Hiroyuki Kuwano
Journal:  World J Surg       Date:  2005-12       Impact factor: 3.352

7.  Evaluation of treatment strategies for gastric cancer in the elderly according to the number of abnormal parameters on preoperative examination.

Authors:  H Hara; H Isozaki; E Nomura; K Fujii; S Sako; N Tanigawa
Journal:  Surg Today       Date:  1999       Impact factor: 2.549

8.  Surgical resection for gastric cancer in elderly patients: is there a difference in outcome?

Authors:  Reza F Saidi; John L Bell; Paul S Dudrick
Journal:  J Surg Res       Date:  2004-05-01       Impact factor: 2.192

9.  Age-adjusted Charlson Comorbidity Index (ACCI) is a significant factor for predicting survival after radical gastrectomy in patients with gastric cancer.

Authors:  Jian-Xian Lin; Ying-Qi Huang; Jian-Wei Xie; Jia-Bin Wang; Jun Lu; Qi-Yue Chen; Long-Long Cao; Mi Lin; Ru-Hong Tu; Ze-Ning Huang; Ju-Li Lin; Ping Li; Chang-Ming Huang; Chao-Hui Zheng
Journal:  BMC Surg       Date:  2019-05-27       Impact factor: 2.102

Review 10.  Korean Gastric Cancer Association-Led Nationwide Survey on Surgically Treated Gastric Cancers in 2019.

Authors: 
Journal:  J Gastric Cancer       Date:  2021-10-01       Impact factor: 3.720

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