Literature DB >> 35937971

Regulation and Function of Calcium in the Cilium.

Zhaoxia Sun1.   

Abstract

The cilium is a cell surface organelle with unique composition and shape. Although it has now been well appreciated as a signaling compartment for the vertebrate cell, the regulation and function of intraciliary calcium is less clear and sometimes controversial. This review focuses on publications regarding calcium in the cilium and the potential interactions between intraciliary calcium and signaling pathways mediated by cilia. Unresolved questions and future directions in the field are also discussed.

Entities:  

Keywords:  calcium; cilia; left-right asymmetry; mechanosensory; polycystic kidney disease; polycystin; signaling

Year:  2020        PMID： 35937971      PMCID： PMC9351618          DOI： 10.1016/j.cophys.2020.08.019

Source DB:  PubMed          Journal:  Curr Opin Physiol        ISSN： 2468-8673


  74 in total

Review 1.  Calcium signalling: dynamics, homeostasis and remodelling.

Authors:  Michael J Berridge; Martin D Bootman; H Llewelyn Roderick
Journal:  Nat Rev Mol Cell Biol       Date:  2003-07       Impact factor: 94.444

2.  Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube.

Authors:  Miquel Tuson; Mu He; Kathryn V Anderson
Journal:  Development       Date:  2011-10-17       Impact factor: 6.868

3.  Primary cilia enhance kisspeptin receptor signaling on gonadotropin-releasing hormone neurons.

Authors:  Andrew I Koemeter-Cox; Thomas W Sherwood; Jill A Green; Robert A Steiner; Nicolas F Berbari; Bradley K Yoder; Alexander S Kauffman; Paula C Monsma; Anthony Brown; Candice C Askwith; Kirk Mykytyn
Journal:  Proc Natl Acad Sci U S A       Date:  2014-06-30       Impact factor: 11.205

4.  Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents.

Authors:  K Hanaoka; F Qian; A Boletta; A K Bhunia; K Piontek; L Tsiokas; V P Sukhatme; W B Guggino; G G Germino
Journal:  Nature       Date:  2000 Dec 21-28       Impact factor: 49.962

5.  Ankmy2 Prevents Smoothened-Independent Hyperactivation of the Hedgehog Pathway via Cilia-Regulated Adenylyl Cyclase Signaling.

Authors:  Bandarigoda Nipunika Somatilaka; Sun-Hee Hwang; Vivek Reddy Palicharla; Kevin Andrew White; Hemant Badgandi; John Michael Shelton; Saikat Mukhopadhyay
Journal:  Dev Cell       Date:  2020-07-22       Impact factor: 13.417

6.  Uni-directional ciliary membrane protein trafficking by a cytoplasmic retrograde IFT motor and ciliary ectosome shedding.

Authors:  Muqing Cao; Jue Ning; Carmen I Hernandez-Lara; Olivier Belzile; Qian Wang; Susan K Dutcher; Yanjie Liu; William J Snell
Journal:  Elife       Date:  2015-02-17       Impact factor: 8.140

7.  Chlamydomonas PKD2 organizes mastigonemes, hair-like glycoprotein polymers on cilia.

Authors:  Peiwei Liu; Xiaochu Lou; Jenna L Wingfield; Jianfeng Lin; Daniela Nicastro; Karl Lechtreck
Journal:  J Cell Biol       Date:  2020-06-01       Impact factor: 10.539

8.  Lipid Interactions of a Ciliary Membrane TRP Channel: Simulation and Structural Studies of Polycystin-2.

Authors:  Qinrui Wang; Robin A Corey; George Hedger; Prafulla Aryal; Mariana Grieben; Chady Nasrallah; Agnese Baronina; Ashley C W Pike; Jiye Shi; Elisabeth P Carpenter; Mark S P Sansom
Journal:  Structure       Date:  2019-12-02       Impact factor: 5.871

9.  Na+-dependent Ca2+ extrusion governs response recovery in frog olfactory receptor cells.

Authors:  J Reisert; H R Matthews
Journal:  J Gen Physiol       Date:  1998-11       Impact factor: 4.086

10.  Cholesterol accessibility at the ciliary membrane controls hedgehog signaling.

Authors:  Maia Kinnebrew; Ellen J Iverson; Bhaven B Patel; Ganesh V Pusapati; Jennifer H Kong; Kristen A Johnson; Giovanni Luchetti; Kaitlyn M Eckert; Jeffrey G McDonald; Douglas F Covey; Christian Siebold; Arun Radhakrishnan; Rajat Rohatgi
Journal:  Elife       Date:  2019-10-30       Impact factor: 8.140
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