Literature DB >> 3593753

Hypocholesterolemic action of 1-ethoxysilatrane.

P P Mehta, T Ramasarma, C K Kurup.   

Abstract

Intraperitoneal administration of the organosilicon compound 1-ethoxysilatrane to the rat caused a 25% decrease in the concentration of cholesterol in serum without affecting that of triacylglycerols. The specific activity of 3-hydroxy-3-methylglutaryl CoA reductase, the rate-limiting enzyme in cholesterol biosynthesis, was depressed in hepatic microsomes of silatrane-treated animals.

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Year:  1987        PMID： 3593753     DOI： 10.1016/0005-2760(87)90316-x

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  2 in total

1.  Investigations on the mechanism of the hypocholesterolemic action of 1-ethoxysilatrane.

Authors:  P P Mehta; T Ramasarma; C K Kurup
Journal:  Mol Cell Biochem       Date:  1990-09-03       Impact factor: 3.396

2.  Preparation of a soluble 58 kDa-3-hydroxy-3-methylglutaryl CoA reductase from liver microsomes and its inhibition by ethoxysilatrane, a hypocholesterolemic compound.

Authors:  R V Omkumar; P P Mehta; C K Kurup; T Ramasarma
Journal:  Mol Cell Biochem       Date:  1992-03-25       Impact factor: 3.396
  2 in total

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