| Literature DB >> 3593654 |
R L Van den Heuvel, S R Versele, G E Schoeters, O L Vanderborght.
Abstract
Our results demonstrate that in yolk sac, liver, spleen and femoral bone marrow of mice at ages ranging between 11 d of gestation and adult life, important changes in the stromal stem cell population (CFU-f assay) occur which are correlated with haemopoiesis. In the liver, spleen and bone marrow, high numbers of CFU-f precede high haemopoietic stem cell values. As haemopoiesis starts in the spleen, CFU-f numbers in fetal liver are low. Similarly, CFU-f numbers decrease in the spleen as bone marrow haemopoiesis starts. This suggests the existence of a migration stream of stromal stem cells. In spleen and bone marrow, CFU-f numbers decrease towards adult life as these organs maintain a stable haemopoietic activity.Entities:
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Year: 1987 PMID： 3593654 DOI： 10.1111/j.1365-2141.1987.tb06884.x
Source DB: PubMed Journal: Br J Haematol ISSN： 0007-1048 Impact factor: 6.998