| Literature DB >> 3593645 |
A E Kulozik, S L Thein, J S Wainscoat, R Gale, L A Kay, J K Wood, D J Weatherall, E R Huehns.
Abstract
Five patients with heterozygous beta-thalassaemia with an unusually severe clinical picture, low haemoglobin levels occasionally requiring blood transfusion, splenomegaly and unusually prominent basophilic stippling were found to have co-inherited a triple alpha-globin gene arrangement on one chromosome (alpha alpha alpha/alpha alpha). It seems probable that the expression of a single extra alpha-globin gene is sufficient in some patients with heterozygous beta-thalassaemia to give rise to a clinically significant degree of dyserythropoietic anaemia.Entities:
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Year: 1987 PMID： 3593645 DOI： 10.1111/j.1365-2141.1987.tb06898.x
Source DB: PubMed Journal: Br J Haematol ISSN： 0007-1048 Impact factor: 6.998