Literature DB >> 3593346

Evidence for existence of various homologues and analogues of platelet activating factor in a lipid extract of bovine brain.

A Tokumura, K Kamiyasu, K Takauchi, H Tsukatani.   

Abstract

Vasodepressor phospholipid with platelet-aggregating activity was highly purified from a lipid extract of bovine brain and subjected to field desorption-mass spectrometry. It was further analyzed by gas-liquid chromatography-mass spectrometry after hydrolysis with phospholipase C and conversion to tert-butyldimethylsilyl derivatives. Results indicated the presence of four species of platelet activating factor (1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine, PAF) and ten acyl analogues of PAF. The acyl analogues of PAF included species having an sn-2-propionyl or sn-2-butyryl group, which have not been previously detected in natural sources. The total amount of acyl analogues of PAF was much higher than that of PAF.

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Year:  1987        PMID： 3593346     DOI： 10.1016/0006-291x(87)91338-6

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  11 in total

1.  Activities of enzymes involved in the metabolism of platelet-activating factor in neural cell cultures during proliferation and differentiation.

Authors:  E Francescangeli; D Lang; H Dreyfus; A Boila; L Freysz; G Goracci
Journal:  Neurochem Res       Date:  1997-10       Impact factor: 3.996

2.  Modulation of inflammatory platelet-activating factor (PAF) receptor by the acyl analogue of PAF.

Authors:  Vyala Hanumanthareddy Chaithra; Shancy Petsel Jacob; Chikkamenahalli Lakshminarayana Lakshmikanth; Mosale Seetharam Sumanth; Kandahalli Venkataranganayaka Abhilasha; Chu-Huang Chen; Anita Thyagarajan; Ravi P Sahu; Jeffery Bryant Travers; Thomas M McIntyre; Kempaiah Kemparaju; Gopal Kedihithlu Marathe
Journal:  J Lipid Res       Date:  2018-08-23       Impact factor: 5.922

Review 3.  Structural and (patho)physiological diversity of PAF.

Authors:  R N Pinckard; D S Woodard; H J Showell; M J Conklyn; M J Novak; L M McManus
Journal:  Clin Rev Allergy       Date:  1994

Review 4.  Metabolic processing of PAF.

Authors:  F Snyder
Journal:  Clin Rev Allergy       Date:  1994

Review 5.  Enzymes of platelet activating factor synthesis in brain.

Authors:  R R Baker
Journal:  Neurochem Res       Date:  1995-11       Impact factor: 3.996

6.  Vitamin C blocks inflammatory platelet-activating factor mimetics created by cigarette smoking.

Authors:  H A Lehr; A S Weyrich; R K Saetzler; A Jurek; K E Arfors; G A Zimmerman; S M Prescott; T M McIntyre
Journal:  J Clin Invest       Date:  1997-05-15       Impact factor: 14.808

7.  Lipid peroxidation in low density lipoproteins from human plasma and egg yolk promotes accumulation of 1-acyl analogues of platelet-activating factor-like lipids.

Authors:  A Tokumura; M Toujima; Y Yoshioka; K Fukuzawa
Journal:  Lipids       Date:  1996-12       Impact factor: 1.880

8.  Capillary gas chromatography and tandem mass spectrometry of paf-acether and analogs: absence of 1-O-alkyl-2-propionyl-sn-glycero-3-phosphocholine in human polymorphonuclear neutrophils.

Authors:  M J Bossant; R Farinotti; F De Maack; G Mahuzier; J Benveniste; E Ninio
Journal:  Lipids       Date:  1989-02       Impact factor: 1.880

9.  Molecular heterogeneity of platelet-activating factor (PAF) in rat glandular stomach determined by gas chromatography/mass spectrometry. PAF molecular species changes upon water-immersion stress.

Authors:  J Sugatani; K Fujimura; M Miwa; K Satouchi; K Saito
Journal:  Lipids       Date:  1991-12       Impact factor: 1.880

10.  Properties of PAF-synthesizing phosphocholinetransferase and evidence for lysoPAF acetyltransferase activity in rat brain.

Authors:  G Goracci; E Francescangeli
Journal:  Lipids       Date:  1991-12       Impact factor: 1.880
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