Cristina Borràs-Novell1, Ana Herranz Barbero2, Carla Balcells Esponera3, Miriam López-Abad3, Victoria Aldecoa Bilbao2, Montserrat Izquierdo Renau3, Isabel Iglesias Platas3,4. 1. Neonatology Department. BCNatal - Centre de Medicina Maternofetal i Neonatologia de Barcelona. Hospital Clínic, Universitat de Barcelona, Barcelona, Spain. cborrasn@clinic.cat. 2. Neonatology Department. BCNatal - Centre de Medicina Maternofetal i Neonatologia de Barcelona. Hospital Clínic, Universitat de Barcelona, Barcelona, Spain. 3. Neonatology Department. BCNatal - Centre de Medicina Maternofetal i Neonatologia de Barcelona. Hospital Sant Joan de Déu, Universitat de Barcelona, Barcelona, Spain. 4. Neonatal Intensive Care Unit, Norfolk and Norwich University Hospital, Norwich, UK.
Abstract
OBJECTIVE: To identify changes in macronutrient content of very preterm human milk associated with perinatal factors. STUDY DESIGN: Milk macronutrients were measured on weeks 1, 2, 4 and 8 with mid-infrared transmission spectrometers. RESULT: We assessed 625 samples (from 117 mothers and 130 very preterm infants). Average concentrations were: protein 1.3 ± 0.3 g/dl, carbohydrates 7.3 ± 0.6 g/dl, fat 3.7 ± 1.0 g/dl and energy 296.0 ± 41.0 kJ/dl (70.7 kcal/dl). Gestational age negatively correlated with protein (rho: -0.307, p < 0.001) and energy (r: -0.193, p = 0.003). Advanced maternal age, gestational age and intrauterine growth restriction were independently associated with milk protein content over the first 4 weeks (adjusted R2: 0.113, p = 0.002). CONCLUSION: These findings may help neonatologists identify patients fed Mother´s Own Milk who are at increased risk of poor postnatal growth.
OBJECTIVE: To identify changes in macronutrient content of very preterm human milk associated with perinatal factors. STUDY DESIGN: Milk macronutrients were measured on weeks 1, 2, 4 and 8 with mid-infrared transmission spectrometers. RESULT: We assessed 625 samples (from 117 mothers and 130 very preterm infants). Average concentrations were: protein 1.3 ± 0.3 g/dl, carbohydrates 7.3 ± 0.6 g/dl, fat 3.7 ± 1.0 g/dl and energy 296.0 ± 41.0 kJ/dl (70.7 kcal/dl). Gestational age negatively correlated with protein (rho: -0.307, p < 0.001) and energy (r: -0.193, p = 0.003). Advanced maternal age, gestational age and intrauterine growth restriction were independently associated with milk protein content over the first 4 weeks (adjusted R2: 0.113, p = 0.002). CONCLUSION: These findings may help neonatologists identify patients fed Mother´s Own Milk who are at increased risk of poor postnatal growth.
Authors: Jeffrey D Horbar; Richard A Ehrenkranz; Gary J Badger; Erika M Edwards; Kate A Morrow; Roger F Soll; Jeffrey S Buzas; Enrico Bertino; Luigi Gagliardi; Roberto Bellù Journal: Pediatrics Date: 2015-07 Impact factor: 7.124
Authors: Jan Maly; Iva Burianova; Veronika Vitkova; Eva Ticha; Martina Navratilova; Eva Cermakova Journal: Arch Dis Child Fetal Neonatal Ed Date: 2018-01-20 Impact factor: 5.747
Authors: Sourabh Dutta; Balpreet Singh; Lorraine Chessell; Jennifer Wilson; Marianne Janes; Kimberley McDonald; Shaneela Shahid; Victoria A Gardner; Aune Hjartarson; Margaret Purcha; Jennifer Watson; Chris de Boer; Barbara Gaal; Christoph Fusch Journal: Nutrients Date: 2015-01-08 Impact factor: 5.717