Combined portable cone beam computed tomography and robotic-assisted bronchoscopy impacting diagnosis of a solitary pulmonary nodule: a case report.

Background: Lung cancer is the leading cause of cancer-related mortality in men and women throughout the world. Historically, bronchoscopy played a limited role in pulmonary nodule management due to a limited diagnostic accuracy. With the emergence of robotic bronchoscopy, proceduralists can now navigate to more peripheral lesions completely extrinsic to the airways with increased diagnostic yield. Despite the increased diagnostic yield from robotic-assisted bronchoscopy, challenges in exact localization of the lesion during a procedure can occur. This case highlights a novel use of robotic bronchoscopy combined with mobile three-dimensional (3D) imaging to optimize lesion location for biopsy previously not reported in the literature. Case Description: We describe a case where the combination of robotic bronchoscopy with new mobile 3D imaging was essential for the accurate biopsy of an incidentally found pulmonary nodule in a 72-year-old woman. Initial navigation to the nodule using robotic bronchoscopy resulted in the catheter being inferior to the area of interest. After renavigation using the information provided by mobile 3D imaging, we were able to confirmed tool-in-lesion prior to biopsy. The patient was diagnosed with adenocarcinoma with papillary features and underwent a lobectomy with a favorable prognosis. Conclusions: A diagnosis of adenocarcinoma was made for this patient utilizing the novel combined technique of robotic peripheral pulmonary nodule biopsy with portable 3D imaging, which may improve overall diagnostic accuracy of bronchoscopic biopsy. 2022 AME Case Reports. All rights reserved.

Introduction

Lung cancer is the leading cause of cancer-related mortality in men and women throughout the world and accounts for 23% of cancer deaths in the US (1-3). To detect lung cancer at an earlier stage, an annual computed tomography (CT) chest is recommended for at-risk individual screening which has led to an increased detection of pulmonary nodules (4). Bronchoscopy historically has played a minor role in pulmonary nodule management due to a limited diagnostic accuracy of 14% to 31% (5). With the emergence of robotic bronchoscopy, biopsy yields have been reported from 69.1% to 81.7% (6-9). However, when diaphragmatic movement distorts nodule positioning and alters the “virtual target” derived from preprocedural CT navigation, reduced diagnostic yield, added procedural time, and possible complications can occur in a phenomenon known as “CT-to-body divergence” (10).

Cone beam computed tomography (CBCT) with fixed c-arms can eliminate divergence by generating a CT-like image in one single, 4–10 seconds, intraprocedural rotation around the patient (11). Improved targeting accuracy and low radiation dose have been seen in studies utilizing CBCT (12). Housing a fixed system in a designated operating room can be cost-prohibitive and interfere with equipment positioning (11). The introduction of portable three-dimensional (3D) fluoroscopy has overcome these hurdles. The CIOS 3D Spin Mobile (Siemens Healthineers, Malvern, PA, USA; ) is compact, mounted on a C-arm, and produces CT images to confirm positioning of biopsy tools prior to sampling as demonstrated in the following case. We present the following case in accordance with the CARE reporting checklist (available at https://acr.amegroups.com/article/view/10.21037/acr-22-5/rc).

Figure 1

The CIOS three-dimensional (3D) Spin Mobile (Siemens Medical Solutions, Malvern, PA, USA) offers a compact, mobile 3D planar image modality that complements robotic bronchoscopic biopsy. The lateral position leaves the head clear for anesthesia and robotic equipment.

Case presentation

A 72-year-old nonsmoker with a history of melanoma presented for nodule evaluation. While the patient was asymptomatic, a routine CT scan for cancer surveillance demonstrated an incidentally found 2.1-cm solid nodule in the right lower lobe that was hypermetabolic on subsequent positron emission tomography (PET) imaging, suspicious for metastasis versus primary lung cancer (). There was an air bronchus sign present. Her physical exam was unremarkable except for stable skin findings from the previously diagnosed melanoma, and she denied relevant medical, family, and psycho-social history.

Figure 2

Computed tomography scan demonstrating a 2.1-cm mass in the right lower lobe that was hypermetabolic on a subsequent positron emission tomography scan.

The patient was enrolled in a clinical trial utilizing combination robotic bronchoscopy and CIOS and consented to participate (NCT04740047). All procedures performed in this study were in accordance with the ethical standards of the institutional and/or national research committee(s) and with the Helsinki Declaration (as revised in 2013). Written informed consent was obtained from the patient for publication of this case report and accompanying images. A copy of the written consent is available for review by the editorial office of this journal.

The patient was intubated for the procedure, and the ventilator was sent to tidal volumes between 6 to 8 mL/kg of ideal body weight, with a predisposition for higher tidal volumes and lower respiratory rates. Given the location of the lower lobe lesion, positive end-expiratory pressure (PEEP) was set to 15 cmH2O. The lesion of interest was placed in the center of the c-arm by adjusting the table and/or c-arm position using lasers from the c-arm (, ). The CIOS was rotated 90° left anterior oblique to 90° right anterior oblique to ensure clearance of all equipment ().

Figure 3

The anatomy of interest is set to the isocenter of the c-arm by aligning the lasers with the final alignment confirmed using a short fluoroscopic pulse. The anteroposterior and lateral planes are of the c-arms are visualized with the crosshairs denoting the approximately nodule location.

Video 1

The lesion of interest is set to the isocenter of the c-arm by adjusting the table and/or c-arm position.

Figure 4

Rotation of the CIOS which ensures clearance of the anesthesia circuit, access, lines and other equipment. The proceduralist has unobstructed access to the patient’s head.

Using the controller and navigation guidance, the proceduralist drove the catheter under live visualization to the target. A 30 second intraoperative CBCT scan with an inspiratory hold at 20 cmH2O visualized the catheter tip relative to the target nodule (, ). Measurements were obtained in three axes, including distance to the nodule and the catheter orientation, which showed the tool 18 mm inferior to the nodule. Re-registration and re-navigation showed tool-in-lesion on repeat spin with radial endobronchial ultrasound (EBUS) confirming proximity to the lesion (). Biopsies taken were immediately available for pathology review which consisted of a 23-gauge needle and forceps, both of which demonstrated adenocarcinoma with papillary features on the first pass. The total time for the robotic procedure was 18 minutes from docking to undocking. The lymph node pathology from 4R and 11R was negative for malignancy, and she proceeded with lobectomy due to the nodule margins with a favorable prognosis. There were no adverse or unanticipated results. She is currently being observed for reoccurrence by her surgical oncology team.

Video 2

A 30-second intraoperative mobile imaging scan visualized the catheter tip relative to the target nodule.

Figure 5

A 30-second intraoperative cone beam computed tomography scan is performed with the CIOS to visualize the catheter tip and its relationship to the target nodule.

Figure 6

User interface snapshots of first pass (left panel) following the predesignated navigation CIOS showing reaching of the target based on the software but with the imaging demonstrating the biopsy tool inferior to nodule. Renavigation (right panel) showing tool-in-lesion in the CIOS images despite the robotic navigation not followed. Radial endobronchial ultrasound signal in the left lower quadrant of the right panel confirming location.

Discussion

This case demonstrates how the novel portable 3D imaging modality can complement robotic bronchoscopy and alter the diagnostic accuracy of a biopsy. The robotic bronchoscope provides information on the proximity and orientation to critical structures with the CIOS imaging contributing information on spatial relationships between the catheter, airway, and nodule. This combination enables position refinement and confirmation of tool-in-lesion which is important when distinguishing sampling error from a true negative in benign nodule biopsy. In addition, the CIOS can be positioned around the patient with no effect on the proceduralist’s or anesthesiologist’s workspace, can be used in any room, and appears to have a low radiation profile.

The CIOS system has been previously described in limited case series in the literature. Avasarala et al combined electromagnetic navigation with CIOS and found a tool-in-lesion rate of 100% of procedures. Despite this, there was no correlation to increased diagnostic yield (13). Kalchiem-Dekel et al. reported their experience with 10 lesions in 5 patients using Shape-sensing robotic-assisted bronchoscopy (SSRAB) in conjunction with the CIOS Mobile 3D spin. In 90% of cases, tool-in-lesion was captured, and the relationship of the biopsy tool and lesion was improved in 3 cases (30%) based on direct information obtained from the intraoperative imaging (8).

The diagnosis was obtained for this patient utilizing the novel combined technique of robotic peripheral pulmonary nodule biopsy with portable 3D imaging, which may improve overall diagnostic accuracy of bronchoscopic biopsy. Further clinical trials are warranted to assess utility of robotic bronchoscopy and 3D planar imaging.

Conclusions/take-away

The diagnosis of peripheral pulmonary nodules may be improved utilizing the novel combination of robotic bronchoscopy with portable 3D imaging to verify tool-in-lesion prior to biopsy.

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