Literature DB >> 35928194

Personalised future prescribing using pharmacogenomics: A resumé of a joint Royal College of Physicians / British Pharmacological Society working party report.

Cameron G Swift1.   

Abstract

There is rapidly growing recognition of the important contribution of individually carried genetic factors to drug response variation (pharmacogenomics) for an increasingly wide range of drugs and of the resulting implications for healthcare across multiple specialisms. This concise overview of the March 2022 joint report of the Royal College of Physicians and the British Pharmacological Society on this topic outlines its coverage of aspects of scientific rationale (with examples), the so far largely unmet need for planned, systematic implementation and training within the UK NHS, and the key forward strategies required. They include a centrally funded, well defined developmental service design with implementation priorities, clinical decision support, clear clinical governance and ongoing research, public and patient engagement, and agreed, updated education and training packages. © Royal College of Physicians 2022 All rights reserved.

Entities:  

Keywords:  drug response; forward strategy; implementation; pharmacogenomics; report overview

Year:  2022        PMID: 35928194      PMCID: PMC9345247          DOI: 10.7861/fhj.rev-9.2.1

Source DB:  PubMed          Journal:  Future Healthc J        ISSN: 2514-6645


  9 in total

1.  Reduced-function CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: a meta-analysis.

Authors:  Jessica L Mega; Tabassome Simon; Jean-Philippe Collet; Jeffrey L Anderson; Elliott M Antman; Kevin Bliden; Christopher P Cannon; Nicolas Danchin; Betti Giusti; Paul Gurbel; Benjamin D Horne; Jean-Sebastian Hulot; Adnan Kastrati; Gilles Montalescot; Franz-Josef Neumann; Lei Shen; Dirk Sibbing; P Gabriel Steg; Dietmar Trenk; Stephen D Wiviott; Marc S Sabatine
Journal:  JAMA       Date:  2010-10-27       Impact factor: 56.272

2.  Codeine and morphine pathway.

Authors:  Caroline F Thorn; Teri E Klein; Russ B Altman
Journal:  Pharmacogenet Genomics       Date:  2009-07       Impact factor: 2.089

3.  Carbamazepine-induced toxic effects and HLA-B*1502 screening in Taiwan.

Authors:  Pei Chen; Juei-Jueng Lin; Chin-Song Lu; Cheung-Ter Ong; Peiyuan F Hsieh; Chih-Chao Yang; Chih-Ta Tai; Shey-Lin Wu; Cheng-Hsien Lu; Yung-Chu Hsu; Hsiang-Yu Yu; Long-Sun Ro; Chung-Ta Lu; Chun-Che Chu; Jing-Jane Tsai; Yu-Hsiang Su; Sheng-Hsing Lan; Sheng-Feng Sung; Shu-Yi Lin; Hui-Ping Chuang; Li-Chen Huang; Ying-Ju Chen; Pei-Joung Tsai; Hung-Ting Liao; Yu-Hsuan Lin; Chien-Hsiun Chen; Wen-Hung Chung; Shuen-Iu Hung; Jer-Yuarn Wu; Chi-Feng Chang; Luke Chen; Yuan-Tsong Chen; Chen-Yang Shen
Journal:  N Engl J Med       Date:  2011-03-24       Impact factor: 91.245

4.  DPYD genotype-guided dose individualisation of fluoropyrimidine therapy in patients with cancer: a prospective safety analysis.

Authors:  Linda M Henricks; Carin A T C Lunenburg; Femke M de Man; Didier Meulendijks; Geert W J Frederix; Emma Kienhuis; Geert-Jan Creemers; Arnold Baars; Vincent O Dezentjé; Alexander L T Imholz; Frank J F Jeurissen; Johanna E A Portielje; Rob L H Jansen; Paul Hamberg; Albert J Ten Tije; Helga J Droogendijk; Miriam Koopman; Peter Nieboer; Marlène H W van de Poel; Caroline M P W Mandigers; Hilde Rosing; Jos H Beijnen; Erik van Werkhoven; André B P van Kuilenburg; Ron H N van Schaik; Ron H J Mathijssen; Jesse J Swen; Hans Gelderblom; Annemieke Cats; Henk-Jan Guchelaar; Jan H M Schellens
Journal:  Lancet Oncol       Date:  2018-10-19       Impact factor: 41.316

Review 5.  Clinical relevance of DPYD variants c.1679T>G, c.1236G>A/HapB3, and c.1601G>A as predictors of severe fluoropyrimidine-associated toxicity: a systematic review and meta-analysis of individual patient data.

Authors:  Didier Meulendijks; Linda M Henricks; Gabe S Sonke; Maarten J Deenen; Tanja K Froehlich; Ursula Amstutz; Carlo R Largiadèr; Barbara A Jennings; Anthony M Marinaki; Jeremy D Sanderson; Zdenek Kleibl; Petra Kleiblova; Matthias Schwab; Ulrich M Zanger; Claire Palles; Ian Tomlinson; Eva Gross; André B P van Kuilenburg; Cornelis J A Punt; Miriam Koopman; Jos H Beijnen; Annemieke Cats; Jan H M Schellens
Journal:  Lancet Oncol       Date:  2015-10-23       Impact factor: 41.316

6.  HLA-B*5701 screening for hypersensitivity to abacavir.

Authors:  Simon Mallal; Elizabeth Phillips; Giampiero Carosi; Jean-Michel Molina; Cassy Workman; Janez Tomazic; Eva Jägel-Guedes; Sorin Rugina; Oleg Kozyrev; Juan Flores Cid; Phillip Hay; David Nolan; Sara Hughes; Arlene Hughes; Susanna Ryan; Nicholas Fitch; Daren Thorborn; Alastair Benbow
Journal:  N Engl J Med       Date:  2008-02-07       Impact factor: 91.245

7.  Clinical Pharmacogenetics Implementation Consortium Guideline for the Use of Aminoglycosides Based on MT-RNR1 Genotype.

Authors:  John Henry McDermott; Joshua Wolf; Keito Hoshitsuki; Rachel Huddart; Kelly E Caudle; Michelle Whirl-Carrillo; Peter S Steyger; Richard J H Smith; Neal Cody; Cristina Rodriguez-Antona; Teri E Klein; William G Newman
Journal:  Clin Pharmacol Ther       Date:  2021-06-20       Impact factor: 6.875

Review 8.  HLA genotype and carbamazepine-induced cutaneous adverse drug reactions: a systematic review.

Authors:  V L Yip; A G Marson; A L Jorgensen; M Pirmohamed; A Alfirevic
Journal:  Clin Pharmacol Ther       Date:  2012-11-07       Impact factor: 6.875

9.  HLA B*5701 status, disease progression, and response to antiretroviral therapy.

Authors: 
Journal:  AIDS       Date:  2013-10-23       Impact factor: 4.177

  9 in total
  1 in total

1.  Public perceptions of pharmacogenomic services in Ireland - Are people with chronic disease more likely to want service availability than those without? A questionnaire study.

Authors:  Joseph O'Shea; Cristín Ryan; Joseph Gallagher; Claire O'Brien; Conor Morris; Eoin Dwyer; James Mc Laughlin; Laura Fitzpatrick; Maire O'Meara; Sarah Kelly; Sophie Knox; Mark Ledwidge
Journal:  Explor Res Clin Soc Pharm       Date:  2022-09-21
  1 in total

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