Alessandra Sansavini1, Luigi Corvaglia2,3, Silvia Martini4,5, Silvia Savini1. 1. Department of Psychology, University of Bologna, Bologna, Italy. 2. Neonatal Intensive Care Unit, IRCCS AOU S. Orsola, Via Massarenti 13-40138, Bologna, Italy. 3. Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy. 4. Neonatal Intensive Care Unit, IRCCS AOU S. Orsola, Via Massarenti 13-40138, Bologna, Italy. silvia.martini9@unibo.it. 5. Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy. silvia.martini9@unibo.it.
Abstract
This observational study aimed to investigate whether predischarge cerebral oxygenation (CrSO2), monitored by near-infrared spectroscopy, correlates with later psychomotor outcome in very preterm infants. Infants <32 weeks' gestation or <1500 g without evidence of major brain lesions underwent a 3-h continuous CrSO2 monitoring before hospital discharge. Psychomotor development was assessed at 6, 12, 18, and 24 months using the Griffiths Mental Developmental Scales. The developmental quotients (DQ) at each follow-up appointment were correlated with predischarge CrSO2. Significant correlations were adjusted for possible confounders. Sixty-three infants were enrolled. A significant correlation between CrSO2 and DQ was observed at 6 months ca (p=0.010), but not at later psychomotor assessments. This correlation was confirmed significant (b=0.274, p=0.038) even after the adjustment for relevant covariates. Conclusion: According to these preliminary findings, the association between predischarge CrSO2 and psychomotor development over the first 24 months in preterm infants without major brain lesions is time-limited. Hence, this parameter may not represent an effective predictor for medium-term neurodevelopment. What is Known: • Prematurity is a major risk factor for adverse neurodevelopment. • The validation of clinical tools for psychomotor outcome prediction may aid to identify high-risk preterm infants who might benefit from early interventions. What is New: • In infants without major brain lesions, predischarge CrSO2 correlates with psychomotor outcome at 6 months ca but not later, indicating a short time predictability.
This observational study aimed to investigate whether predischarge cerebral oxygenation (CrSO2), monitored by near-infrared spectroscopy, correlates with later psychomotor outcome in very preterm infants. Infants <32 weeks' gestation or <1500 g without evidence of major brain lesions underwent a 3-h continuous CrSO2 monitoring before hospital discharge. Psychomotor development was assessed at 6, 12, 18, and 24 months using the Griffiths Mental Developmental Scales. The developmental quotients (DQ) at each follow-up appointment were correlated with predischarge CrSO2. Significant correlations were adjusted for possible confounders. Sixty-three infants were enrolled. A significant correlation between CrSO2 and DQ was observed at 6 months ca (p=0.010), but not at later psychomotor assessments. This correlation was confirmed significant (b=0.274, p=0.038) even after the adjustment for relevant covariates. Conclusion: According to these preliminary findings, the association between predischarge CrSO2 and psychomotor development over the first 24 months in preterm infants without major brain lesions is time-limited. Hence, this parameter may not represent an effective predictor for medium-term neurodevelopment. What is Known: • Prematurity is a major risk factor for adverse neurodevelopment. • The validation of clinical tools for psychomotor outcome prediction may aid to identify high-risk preterm infants who might benefit from early interventions. What is New: • In infants without major brain lesions, predischarge CrSO2 correlates with psychomotor outcome at 6 months ca but not later, indicating a short time predictability.
Authors: Thomas Alderliesten; Frank van Bel; Niek E van der Aa; Paul Steendijk; Ingrid C van Haastert; Linda S de Vries; Floris Groenendaal; Petra Lemmers Journal: J Pediatr Date: 2018-12-18 Impact factor: 4.406
Authors: Elise A Verhagen; Koenraad N J A Van Braeckel; Christa N van der Veere; Henk Groen; Peter H Dijk; Christian V Hulzebos; Arend F Bos Journal: Dev Med Child Neurol Date: 2014-11-08 Impact factor: 5.449