Basic Determinants of Disease Knowledge in COPD Patients: Results from COSYCONET.

Introduction: In many chronic diseases, including COPD, the patients' basic knowledge of the disorder has been shown to be relevant for the course of the disease. We studied which clinical and functional characteristics were related to this knowledge as well as the patients' satisfaction with their knowledge about COPD.
Methods: The study population comprised 645 patients of GOLD grades 1-4 who participated in Visit 6 of the COSYCONET cohort (COPD and Systemic Consequences - Comorbidities Network). The assessments covered a broad panel of clinical and functional characteristics, including generic and disease-specific quality of life and the COPD Assessment Test (CAT). The study aim was addressed by two questions, referring to patients' knowledge of the meaning of FEV1 and the overall satisfaction with their knowledge of COPD.
Results: Knowledge of FEV1 was higher in patients of higher spirometric GOLD grades or exacerbation risk, in males, with higher educational level, and after participation in a prior educational training on COPD. Patients with more detailed knowledge showed a higher satisfaction with their knowledge. Satisfaction was associated with higher generic quality of life and a lower CAT score. Furthermore, satisfaction was higher in patients with a treatment plan but lower in patients with cardiac comorbidities. It appeared that females with basic education, high burden from COPD and low quality of life had the greatest knowledge deficits. Discussion: The results suggest room for education programs adapted to the educational level of the participants. They also emphasize the major role of a disease management plan for the patients.

Introduction

Patients with chronic obstructive pulmonary disease (COPD) show a large heterogeneity of their clinical condition that is commonly described by the categorization into GOLD grades 1–4 based on spirometry, and GOLD groups A to D based on symptoms and exacerbation history.1 The respiratory condition and the frequent presence of comorbidities lead to extensive therapy.2 It is reasonable to assume that the therapeutic success depends on patients’ cooperation and possibly their understanding of the disease, both of which can be promoted by education and disease management programs. Indeed, self-management programs have been designed to improve patients’ clinical status3 through behavioral changes, optimized social, emotional and physical impairments.4,5 Although _ENREF_6we did not find clinical status to be a major determinant of the adherence to medication in a previous analysis,6 this might be different with respect to the acquired knowledge about the disease and the need for further information expressed by the patients. This study aimed to investigate the relationship between disease-specific knowledge and clinical and functional characteristics of COPD patients. In an analogous manner, we analyzed patient satisfaction with COPD-specific knowledge to identify potential needs for action. To elucidate such associations and potential needs, we analyzed the responses to two basic questions on patients’ knowledge and their satisfaction with their knowledge of the disease, using data from the large, multi-center German COPD study COSYCONET (COPD and Systemic Consequences - Comorbidities Network) addressing different aspects of COPD research.7–11 These data comprised information on anthropometric, clinical and lung function characteristics, time since diagnosis, education level, participation in a disease management program, availability of a treatment plan and whether the treating physician was a pneumologist.

Materials and Methods

Assessments

The observational German COPD cohort study COSYCONET (“COPD and SYstemic consequences-COmorbidities NETwork”) investigates the interaction of lung disease, comorbidities and systemic inflammation and n=2741 patients with COPD were included into visit 1 of COSYCONET.12 Details of the COSYCONET study have been published previously12. Inclusion criteria comprised aged 40 years and older, diagnosis of COPD (according to GOLD criteria) or chronic bronchitis, availability for repeated study visits over at least 18 months and exclusion criteria comprised having undergone major lung surgery, moderate or severe exacerbation within the last 4 weeks, having a lung tumor, physical or cognitive impairment resulting in an inability to walk or to understand the intention of the project.12 Follow-up visits were performed after 6, 18, 36, 54 and 72 months. At the time of the 72-month visit, 776 patients still participated in the study. At this point in time, questions “Do you know the term FEV1 (forced expiratory volume in one second)” and “How satisfied are you with your knowledge and understanding regarding COPD?” were introduced into the COSYCONET questionnaires. Only patients of spirometric GOLD grades 1–41 were included in visit 6 (see Figure 1). At each visit, the assessments of COSYCONET comprised a detailed clinical history, anthropometric data, lung function, time since COPD diagnosis, comorbidities based on patients’ reports of physician-based diagnoses, symptoms, exacerbation history, physical activity by the International Physical Activity Questionnaire (IPAQ), and quality of life via the visual analogue scale (VAS) of the EQ-5D-3L and the disease-specific St George’s Respiratory Questionnaire (SGRQ). All visits followed standard operating procedures (SOP).12 Education level was grouped into three categories based on the number of years of education completed (basic education ≤9 years, secondary education 10 to 11 years, higher education >11 years).13 Moreover, patients were questioned regarding participation in a disease management program, availability of a treatment plan and whether the treating physician was a pneumologist.

Figure 1

Flow-chart diagram of the study population.

The assumed basic knowledge of COPD was assessed based on the question “Do you know the term FEV1 (forced expiratory volume in one second)”; the answers were either yes or no. This was considered relevant as FEV1 plays a fundamental role in the categorization of COPD and could be assumed to be known to patients who had already performed a considerable number of lung function tests. The level of further information desired by patients was assessed by the question “How satisfied are you with your knowledge and understanding regarding COPD?”; answers were given on a Likert scale ranging from 0 (not at all) to 6 (very satisfied).

The COSYCONET study was approved by the Ethical Committee of the coordinating center (University of Marburg) and those of all study centers, as well as the respective data security authorities (data security agency of the federal states of Hesse, Baden-Württemberg, Lower-Saxony and Saarland). Moreover, it followed the declaration of Helsinki and Good Clinical Practice Guidelines. All patients gave their written informed consent. Clinical Trial registration: NCT01245933.

Data Analysis

For descriptive purposes, median values [quartiles] and numbers or percentages were computed, depending on the type of data. Statistical comparisons between groups were performed using contingency tables and the chi-square statistics, or the Mann–Whitney-U-Test, depending on the type of data and comparison. As only few patients showed low score points in the satisfaction with COPD knowledge, we defined a new binary variable comprising 0–4 versus 5–6 points based on ROC (receiver operator characteristics) analysis with knowledge as outcome. This simplification was done in order to make the analyses of satisfaction and knowledge more comparable.

Multiple binary logistic regression analysis was employed to identify statistically independent predictors of knowledge and satisfaction. The predictors used were age, sex, GOLD grades, symptoms (GOLD BD vs AC), exacerbations (GOLD CD vs AB), IPAQ, CAT, EQ-5D-3L VAS, patients’ education category, participation in COPD education, participation in a COPD disease management program, a COPD treatment plan and the specialty of the treating physician (pneumologist vs others) as well as the comorbidities coronary artery disease (CAD), myocardial infarction (MI), heart failure (HF), hypertension, peripheral artery disease (PAD), diabetes, hyperlipidemia, hyperuricemia, osteoporosis, mental disorders, sleep apnea and asthma. The comorbidities were analyzed through four sum scores comprising the number of respiratory, cardiac, vascular and metabolic disorders, whereby osteoporosis was counted separately due to its special relation to COPD resulting from corticosteroid therapy. GOLD grades 1–4 were treated as categorical variables relative to grade 1. We omitted the SGRQ from the analysis due to its high collinearity with CAT and VAS. In case of knowledge, satisfaction was included as additional predictor, in case of satisfaction, knowledge. Analyses were performed using inclusion of all predictors and repeated with forward and backward selection to confirm that the set of predictors identified as significant was the same and thus the result could be considered as statistically reliable. For the sake of brevity, only the significant predictors are shown in the graphs, and the presented estimates refer to analyses restricted to these predictors. Statistical significance was assumed for p<0.05. All analyses were performed using the software package SPSS (IBM SPSS Statistics for Macintosh, Version 28.0., Armonk, NY, USA).

Results

Study Population

In total, 645 patients of GOLD grades 1–4 participated in the 72-month follow-up visit and answered the questions regarding COPD knowledge and satisfaction (Table 1). Of these, 235 (36.4%) stated to be familiar with the term FEV1. Satisfaction with COPD knowledge at Likert points 0–6 was reported by 1.2, 3.4, 7.6, 26.4, 23.7, 24.0 and 13.6% of patients, respectively, resulting in 243 patients (37.7%) in the category of ≥5 points.

Table 1

Patient Characteristics (n=645) of the Study Cohort

Variable	Numbers (%)/ Median [Quartiles]
FEV1% predicted (GLI)	51.6 [38.5, 67.5]
FVC % predicted (GLI)	80 [66.5, 93]
EQ-5D-3L VAS (mm)	60 [40, 70]
CAT (score 0–40)	18 [13, 23]
SGRQ (score 0–100)	40,2 [25.7, 55.4]
mMRC (score 0–4)	1 [1, 2]
IPAQ (points)	2182 [693, 5610]
Reported knowledge of FEV1 (yes) (%)	235 (36.4%)
High satisfaction with knowledge (score 5 or 6 among 0–6) (%)	243 (37.7%)
Previous educational training on COPD (yes) (%)	278 (43.1%)
GOLD grades 1/2/3/4 (%)	70/274/242/59 (10.9%/42.5%/37.5%/9.1%)
GOLD groups A/B/C/D (%)	381/66/131/64 (59.1%/10.2%/20.3%/9.9%)
Number of cardiac comorbidities (0/1/2/3) (%)	443/112/48/27 (69.0%/17.4%/7.5%/4.2%)
Number of vascular comorbidities (0/1/2) (%)	240/319/71 (37.4%/49.7/11.1%)
Number of respiratory comorbidities (0/1/2) (%)	385/211/33 (60.0%/32.9%/5.1%)
Number of metabolic comorbidities(0/1/2/3) (%)	233/243/134/22 (36.1%/37.7%/20.9%/3.4%)
Diagnosis of osteoporosis (yes) (%)	144 (22.3%)
Treatment plan for COPD (yes) (%)	129 (20.1%)
Participation in COPD disease management program (yes) (%)	150 (23.4%)
Time since diagnosis of COPD (years)	12 [9, 16]
Treating physician pneumologist (yes) (%)	478 (74.5%)
Education level (basic/secondary/higher)* (%)	298/199/135 (46.2%/30.9%/21.0%)

Notes: Numbers and percentages or median values and quartiles [in brackets] are given. *Educational level: basic (9 years), secondary (10 years), higher (12 years).

Abbreviations: BMI, body mass index; GLI, Global Lung Function Initiative; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity, EQ-5D-3L; VAS, Visual Analog Scale of the European Quality of Life 5 Dimensions 3 Level Version questionnaire; CAT, COPD Assessment Test; SGRQ, St George’s Respiratory Questionnaire; mMRC, modified Medical Research Council; GOLD, Global Initiative for Chronic Obstructive Lung Disease.

Associations of Reported Knowledge of FEV1

The results of univariate analyses using contingency tables and the Mann–Whitney-U-Test are summarized in Tables 2 and 3. There were associations with multiple variables that were checked in multiple logistic regression analyses for being statistically independent predictors. Male sex, GOLD grades 3 and 4 compared to grade 1, higher exacerbation score, previous education on COPD, osteoporosis, participation in a COPD disease management program, secondary and high compared to low education as well as satisfaction with knowledge were significant simultaneous predictors of greater knowledge (p<0.05 each), while CAT, EQ-5D-3L VAS, IPAQ and other comorbidity scores were not relevant. This was confirmed by forward and backward selection. The results are shown in Figure 2 in terms of odds ratios.

Table 2

Associations of Reported Knowledge of FEV1

Variable	Reported Knowledge of FEV1 (Yes)	p-value
Sex (male/female)	38.5%/34.0%	0.238
Age (years)	68.5 vs 72.0	<0.001
GOLD groups A/B/C/D (%)	31.0/33.3%/45.8%/54.7%	<0.001
GOLD grades 1/2/3/4 (%)	21.4%/26.8%/46.3%/60.3%	<0.001
Number of respiratory comorbidities (0/1/2) (%)	32.3%/40.8%/50.0%	0.027
Number of cardiac comorbidities (0/1/2/3) (%)	38.1%/30.4%/31.3%/37.0%	0.407
Number of vascular comorbidities (0/1/2) (%)	35.4%/38.6%/28.2%	0.245
Number of metabolic comorbidities without osteoporosis (0/1/2/3) (%)	34.3%/37.4%/37.0%/31.8%	0.870
Diagnosis of osteoporosis (yes/no) (%)	45.8%/33.1%	0.005
CAT (score)	17.5 vs 18.0	0.485
EQ-5D-3L VAS (mm)	60.0 vs 60.0	0.153
SGRQ (score)	42.8 vs 38.9	0.94
IPAQ (points)	1897.5 vs 2376.0	0.146
Time since diagnosis of COPD (years)	13.0 vs 11.0	0.047
Participation in COPD education (yes/no) (%)	51.1%/25.1%	<0.001
Participation in COPD disease management program (yes/no) (%)	56.7%/30.6%	<0.001
COPD treatment plan (yes/no) (%)	51.2%/32.7%	<0.001
Treating physician pneumologist (yes/no) (%)	36.4%/37.2%	0.857
Educational level (b/s/h) * (%)	27.0%/43.4%/48.9%	0.05
High satisfaction with knowledge (yes/no) (%)	52.9%/26.8%	<0.001

Notes: Results of univariate analyses of reported knowledge of FEV1 using contingency tables and chi-square-statistics or Mann–Whitney U-tests, depending on the type of data and comparison. Statistically significant results are marked in boldface. *Educational level: basic (9 years), secondary (10 years), higher (12 years).

Abbreviations: BMI, body mass index; GLI, Global Lung Function Initiative; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity, EQ-5D-3L; VAS, Visual Analog Scale of the European Quality of Life 5 Dimensions 3 Level Version questionnaire; CAT, COPD Assessment Test; SGRQ, St George’s Respiratory Questionnaire; mMRC, modified Medical Research Council; GOLD, Global Initiative for Chronic Obstructive Lung Disease.

Table 3

Associations of High Satisfaction with Knowledge on COPD

Variable	High Satisfaction with Knowledge (Yes)	p-value
Sex (male/female) (%)	36.6%/39.2%	0.511
Age (years)	69.0 vs 71.0	0.011
GOLD groups A/B/C/D (%)	37.8%/30.3%/41.2%/37.5%	0.526
GOLD grades 1/2/3/4 (%)	37.1%/34.6%/39.3%/46.6%	0.343
Number of respiratory comorbidities (0/1/2) (%)	36.4%/39.3%/38.2%	0.779
Number of cardiac comorbidities (0/1/2/3) (%)	41.8%/28.6%/29.2%/22.2%	0.010
Number of vascular comorbidities (0/1/2) (%)	42.5%/37.6%/21.1%	0.005
Number of metabolic comorbidities without osteoporosis (0/1/2/3) (%)	36.1%/39.1%/40.0%/22.7%	0.328
Diagnosis of osteoporosis (yes/no)	38.9%/37.2%	0.716
CAT (score)	16.0 vs 19.0	<0.001
EQ-5D-3L VAS (mm)	66.5 vs 59.0	<0.001
SGRQ (score)	34.9 vs 42.4	<0.001
IPAQ (points)	2056.0 vs 2240.0	0.818
Time since diagnosis of COPD (years)	12.5 vs 11.0	0.016
Participation in COPD education (yes/no)	45.1%/32.1%	<0.001
Participation in COPD disease management program (yes/no)	42.7%/36.3%	0.161
COPD treatment plan (yes/no)	53.3%/33.7%	<0.001
Treating physician pneumologist (yes/no)	37.4%/38.5%	0.816
Educational level (b/s/h) *	34.1%/39.4%/44.4%	0.595
Reported knowledge of FEV1 (yes/no)	54.5%/28.0%	<0.001

Notes: Results of univariate analyses of high satisfaction with COPD knowledge using contingency tables and chi-square-statistics or Mann–Whitney U-tests, depending on the type of data and comparison. Statistically significant results are marked in boldface. *Educational level: basic (9 years), secondary (10 years), higher (12 years).

Abbreviations: BMI, body mass index; GLI, Global Lung Function Initiative; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity, EQ-5D-3L; VAS, Visual Analog Scale of the European Quality of Life 5 Dimensions 3 Level Version questionnaire; CAT, COPD Assessment Test; SGRQ, St George’s Respiratory Questionnaire; mMRC, modified Medical Research Council; GOLD, Global Initiative for Chronic Obstructive Lung Disease.

Figure 2

Odds ratios and 95% confidence intervals obtained from logistic regression analysis of the reported knowledge of FEV1 versus a comprehensive set of predictors (see Methods). The figure shows the result restricted to those predictors that were consistently found significant with inclusion as well as forward and backward selection. The effects of GOLD grades 3 and 4 were relative to grade 1.

To elucidate whether the effect of educational training on the knowledge of FEV1 was dependent on education, we repeated the analysis separately in patients with either basic education (N=298; 46.2%) or secondary/higher education (N=344; 53.3%). In both groups, GOLD grade 4, participation in a disease management program and satisfaction with COPD knowledge remained as predictors (p<0.05 each). In the group of basic education, exacerbations were additional predictors, in the group with secondary/higher education, osteoporosis, male sex and previous education on COPD (p<0.05 each). For the corresponding odds ratios see the . The differences between groups were small, but the highest GOLD grades were linked to more detailed knowledge, primarily in patients with basic education.

In patients without previous educational training, GOLD grade 3, exacerbations and satisfaction with knowledge were significant predictors (p<0.05 each). In patients with previous educational training, GOLD grade 4, secondary/higher education level, participation in a disease management program and satisfaction with COPD knowledge were significant predictors (p<0.05 each). For the corresponding odds ratios see the . Differences were small, but participation in a disease management program was relevant only in patients with prior educational training.

Associations of Satisfaction with COPD Knowledge

Univariate analyses using contingency tables and the Mann–Whitney-U-Test yielded the results summarized in Table 2. These associations were checked in multiple logistic regression analysis for statistically independent predictors. The results showed statistical significance (p<0.05 each) for higher exacerbations, higher EQ-5D-3L VAS, lower CAT, the existence of a treatment plan, longer time since the diagnosis of COPD, lower cardiac comorbidities and reported knowledge. The corresponding odds ratios are shown in Figure 3.

Figure 3

Odds ratios and 95% confidence intervals obtained from logistic regression analysis of the reported higher satisfaction with COPD knowledge versus a comprehensive set of predictors (see Methods). The figure shows the result restricted to those predictors that were consistently found significant with inclusion as well as forward and backward selection. For better readability, the effects of CAT, EQ-5D-3L VAS and the duration of COPD since diagnosis are given for changes in 10 units of the respective variable.

In patients with basic education a higher EQ-5D-3L VAS, the existence of a treatment plan and knowledge of FEV1 were linked to more satisfaction (p<0.05). In patients with secondary/higher education, a higher EQ-5D-3L VAS, the existence of a treatment plan, lower cardiac comorbidities and knowledge of FEV1 were associated with higher satisfaction (p<0.05). In patients without previous educational training, a lower CAT, the presence of a treatment plan, lower cardiac comorbidities and the knowledge of FEV1 were significant predictors of satisfaction (p<0.05 each). In patients with previous educational training, higher EQ-5D-3L VAS, the presence of a treatment plan, longer time since COPD diagnosis and the knowledge of FEV1 were significant predictors of satisfaction (p<0.05 each). From the it can be seen that for both subcategorizations the differences in odds ratios were small irrespective of statistical significance.

Discussion

The present analysis addressed COPD-relevant knowledge and satisfaction with this knowledge in relation to basic characteristics of patients including educational level and previous participation in educational programs on COPD. The aim was to get hints on the characteristics of patients who lack information and conversely benefit most from educational training. For this purpose, we used two simple questions that had been introduced into the COSYCONET cohort at one of the follow-up visits; these questions referred to the knowledge of the meaning of FEV1 and to the overall satisfaction with the knowledge about COPD.

As expected, the reported knowledge depended on the educational level and the participation in a prior educational training on COPD. Interestingly, it also was higher in patients of higher spirometric GOLD grades or exacerbation risk, as well as in males. Additionally, patients who participated in a disease management program as well as patients with the diagnosis of osteoporosis reported better knowledge. Neither the clinical state as measured by the CAT, nor generic quality of life, reported daily activity, nor the presence of comorbidities played a role. Patients with reported knowledge of FEV1 were also more satisfied with their general knowledge about COPD, suggesting that the specific knowledge regarding FEV1 was considered a relevant part of knowledge.

Satisfaction with the knowledge showed a different pattern of predictors. It depended on the reported knowledge as well as a higher exacerbation score but not on GOLD grades or sex or age. Conversely, it was associated with less COPD complaints in terms of the CAT and higher generic quality of life. Moreover, the presence of cardiac comorbidities was associated with less satisfaction with the knowledge about COPD. Additionally, the presence of a COPD treatment plan as well a longer time since the diagnosis of COPD had a positive effect on the patients’ satisfaction.

These results are in line with the known positive effect of disease knowledge on the course of COPD.4 They furthermore provide insight into which particular patients lack knowledge and suggest that these are females with basic education, high burden from COPD, low quality of life and cardiac disease. Lower educational level is a proxy of socioeconomic status that has been shown to be associated with poorer COPD outcomes,13,14 therefore these patients might benefit from COPD education.

The fact that the estimated effect of previous education on COPD was low in patients with basic education also points towards education programs that are adapted to the needs and understanding of these patients. Thus, different courses might be offered for different levels of education. This could easily be implemented in online courses which not only could help to reconcile the participation with work but also might avoid problems arising from a slower rate of understanding in a group.

Previous studies already investigated the distribution of patients’ disease-specific knowledge in COPD15–17 or other chronic diseases such as diabetes.18,19 These studies often used extensive panels designed for covering a broad spectrum of knowledge. In the present study, we used only two questions. The reason was that the extensive study protocol of COSYCONET12 and the restrictions of time prevented the introduction of more detailed assessments or specific tests to verify the claimed knowledge.

Despite these limitations, the results seem plausible and the questions suitable FEV1 is the basic variable used to categorize COPD into GOLD categories 1–4. These categories are known to the great majority of patients and treating physicians including non-specialists. Moreover, patients are commonly monitored over time involving repeated assessments of lung function and often ask doctors and technicians for the measured values. It therefore appeared reasonable to utilize the knowledge of FEV1 as a proxy of basic knowledge on the disease, similarly to that of HbA1c or glucose levels in diabetes.20 Knowledge on COPD was also related to the presence of osteoporosis. This is known to many patients as a risk of treatment with corticosteroids and of advanced age which is relevant as COPD is primarily a disease of the elderly. Indeed, a great number of patients in COSYCONET are treated with corticosteroids, irrespective of the conformity with treatment recommendations.2

The question regarding satisfaction with the knowledge of COPD did not address a specific topic and covered the whole area of COPD. It is therefore plausible that high satisfaction correlated with other broad-band measures such as CAT and generic quality of life. Satisfaction was lower in patients with a history of cardiac diseases. Experience shows that such diseases are considered as a threat21 which is also reflected in the high adherence to cardiac medication.6 In view of the close link between COPD and cardiac diseases, the feeling of insufficient knowledge seems understandable as patients may put their primary focus on the cardiac disease rather than COPD. Conversely, higher exacerbations and longer duration of COPD seemed to favor satisfaction with COPD knowledge, possibly based on more experience with the successful management of the disease. Another interesting finding was that while the existence of a COPD treatment plan was associated with higher satisfaction, this was not true for the mere participation in a disease management program.

Limitations

This is a cross-sectional study, as the question on knowledge about FEV1 and the question on satisfaction with knowledge was introduced in the course of the COSYCONET study. In the study population, a total of 40% of COPD patients received disease-specific education. This number is likely to be higher than in real-life situations, since participation in an intensive observational study such as COSYCONET should have a selection effect. It can therefore be assumed that COPD-specific knowledge in the general population is lower. Moreover, the single question regarding FEV1 was considered as indicator question for the level of COPD knowledge; this was probably justified as it is a simple, intuitive parameter and many patients are aware of lung function being used for COPD grading. The advantage of this study is the detailed knowledge about the clinical characteristics, thus it was possible to identify patients with the largest gaps of knowledge.

Conclusion

We found that patients with greater disease-specific knowledge in terms of FEV1 had higher satisfaction with their knowledge. Satisfaction was lower in patients with cardiac comorbidities and higher in patients with a treatment plan. Higher satisfaction corresponded to a higher generic quality of life and a lower score in the COPD Assessment Test. It appeared that females with basic education, high burden from COPD and low quality of life had the greatest deficits in knowledge. The results suggest room for education programs that take into account the educational level of the participants and emphasize the role of a disease management plan for the patients.