Dominic Salamone1, Giuseppina Costabile1,2, Alessandra Corrado1, Giuseppe Della Pepa1, Marilena Vitale1, Rosalba Giacco3, Delia Luongo4, Roberta Testa1, Angela Albarosa Rivellese5,6, Giovanni Annuzzi1,2, Lutgarda Bozzetto1,2. 1. Department of Clinical Medicine and Surgery, "Federico II" University, Sergio Pansini, 5, 80131, Naples, Italy. 2. Task Force on Microbiome Studies, University of Naples "Federico II", Naples, Italy. 3. Institute of Food Science, National Research Council, 83100, Avellino, Italy. 4. CNR- Institute of Biostructures and Bioimaging, 80100, Naples, Italy. 5. Department of Clinical Medicine and Surgery, "Federico II" University, Sergio Pansini, 5, 80131, Naples, Italy. rivelles@unina.it. 6. Task Force on Microbiome Studies, University of Naples "Federico II", Naples, Italy. rivelles@unina.it.
Abstract
AIM: aim of the study was to evaluate serum short chain fatty acids (SCFA) concentrations in patients with Type 2 diabetes (T2D) and overweight/obese individuals. METHODS: In forty-three patients with T2D and twenty-eight overweight/obese patients SCFA were determined by Gas-Chromatography/Flame Ionization Detector (GC/FID). RESULTS: Acetic acid, propionic acid, butyric acid, and total SCFA were significantly reduced in T2D patients compared to overweight/obese in the unadjusted model. Adjusting for all variables only propionic acid remained significantly lower in T2D. CONCLUSION: Only reduction of propionic acid was closely related to diabetes itself, regardless of all other factors.
AIM: aim of the study was to evaluate serum short chain fatty acids (SCFA) concentrations in patients with Type 2 diabetes (T2D) and overweight/obese individuals. METHODS: In forty-three patients with T2D and twenty-eight overweight/obese patients SCFA were determined by Gas-Chromatography/Flame Ionization Detector (GC/FID). RESULTS: Acetic acid, propionic acid, butyric acid, and total SCFA were significantly reduced in T2D patients compared to overweight/obese in the unadjusted model. Adjusting for all variables only propionic acid remained significantly lower in T2D. CONCLUSION: Only reduction of propionic acid was closely related to diabetes itself, regardless of all other factors.