Aakash Patel1, Sarang Koushik2, Ruben Schwartz3, Karina Gritsenko1, Fadi Farah1, Ivan Urits4, Giustino Varrassi5, Omar Viswanath6, Naum Shaparin1. 1. Montefiore Medical Center, Albert Einstein School of Medicine. 2. Valleywise Health Medical Center, Creighton University School of Medicine. 3. Keck School of Medicine of USC, Department of Anesthesiology & Pain Medicine. 4. Beth Israel Deaconess Medical Center, Department of Anesthesia, Critical Care, and Pain Medicine, Harvard Medical School. 5. Paolo Procacci Fdn. 6. LSU Health Sciences Center School of Medicine, Creighton University School of Medicine.
Abstract
Background: Facet-mediated pain is a major cause of low back pain and as a result, is a significant cause of morbidity, including disability and reduced functionality. Setting: The present investigation involved a PubMed literature review between June 1, and 2021-January 1, 2022. Methods: We systematically reviewed was carried Pubmed using the search terms "platelet-rich plasma", "inflammatory mediators", "facet arthropathy", "axial back pain", and "leukoreduction". Data extraction and quality assessment were performed by 3 independent reviewers. Out of the studies analyzed 2 were retrospective, while 1 was a prospective study. Results: PRP injections for facet mediated or modulated pain are an alternative to conventional pharmacotherapies and interventional injections/radiofrequency. There are limited numbers of studies in world literature at present. Limitations: Small number of articles in the world literature and small numbers of patients in those published studies. Conclusions: At present, there are limited studies in the literature; however, larger well-designed studies are warranted to precisely understand efficacy, potential side effects and best practice techniques for PRP injections for facet mediated or modulated pain.
Background: Facet-mediated pain is a major cause of low back pain and as a result, is a significant cause of morbidity, including disability and reduced functionality. Setting: The present investigation involved a PubMed literature review between June 1, and 2021-January 1, 2022. Methods: We systematically reviewed was carried Pubmed using the search terms "platelet-rich plasma", "inflammatory mediators", "facet arthropathy", "axial back pain", and "leukoreduction". Data extraction and quality assessment were performed by 3 independent reviewers. Out of the studies analyzed 2 were retrospective, while 1 was a prospective study. Results: PRP injections for facet mediated or modulated pain are an alternative to conventional pharmacotherapies and interventional injections/radiofrequency. There are limited numbers of studies in world literature at present. Limitations: Small number of articles in the world literature and small numbers of patients in those published studies. Conclusions: At present, there are limited studies in the literature; however, larger well-designed studies are warranted to precisely understand efficacy, potential side effects and best practice techniques for PRP injections for facet mediated or modulated pain.
Authors: William R Parrish; Breana Roides; Julia Hwang; Michael Mafilios; Brooks Story; Samir Bhattacharyya Journal: BMJ Open Sport Exerc Med Date: 2016-03-07