Literature DB >> 35907161

A suicide attempt by intramuscular injection of pentobarbital sodium into rectus abdominis suggested by computed tomography.

Ryuichi Nakayama1, Hiroki Sato2, Naoya Yama3, Keishi Ogura4, Ryoko Kyan5, Tomoki Hanazawa5, Tomohiro Yoshizawa5, Masamune Miyamoto5, Yoshito Kamijo5, Hirotoshi Mizuno2, Hirotoshi Inamura6, Keisuke Harada2, Shuji Uemura2, Eichi Narimatsu2.   

Abstract

Suicide attempts in humans due to injections of the veterinary drug pentobarbital sodium have been rarely reported. Herein, we present a case of a suicide attempt by intramuscular injection of pentobarbital sodium into the rectus abdominis muscle, which was suggested by computed tomography (CT). A 73-year-old man was brought to the emergency department with GCS 3 (E1V1M1) and an incised wound on the right side of the neck. A bottle of Somnopentyl® (pentobarbital sodium, 64.8 mg/ml), a 20-ml empty syringe with an 18-mm needle, and no. 10 scalpel were present at the scene. At the emergency department, the patient was intubated and was admitted to the intensive care unit. A urine drug screen test by SIGNIFY® ER was positive for benzodiazepines and barbiturates, and continuous veno-venous hemofiltration (CHF) was initiated. The route of drug administration was initially unknown; however, a CT scan revealed swelling of the left rectus abdominis muscle with a wound suggestive of a needle puncture, and the CT analysis suggested 38.16 ml as the maximum dose of pentobarbital sodium. On day 3, the patient's consciousness improved, and he was weaned off CHF and mechanical ventilation. There have been several reports of postmortem CT yielding information on the site of administration of intoxicants, but there have been none for surviving intoxicated patients. This is the first report of the usefulness of CT to identify the site of administration of the causative agent of intoxication while the patient is still alive.
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  Case report; Computed tomography; Intoxication; Pentobarbital; Suicide attempt

Year:  2022        PMID: 35907161     DOI: 10.1007/s12024-022-00508-y

Source DB:  PubMed          Journal:  Forensic Sci Med Pathol        ISSN: 1547-769X            Impact factor:   2.456


  7 in total

1.  Suicide by injection of a veterinarian barbiturate euthanasia agent: report of a case and toxicological analysis.

Authors:  Nathalie Romain; Christian Giroud; Katarzyna Michaud; Patrice Mangin
Journal:  Forensic Sci Int       Date:  2003-01-28       Impact factor: 2.395

2.  Suicide by Fatal Pentobarbital Intoxication in Ontario, Canada, from 2012 to 2015.

Authors:  Patricia Solbeck; Victoria Snowdon; Ashwyn Rajagopalan; Reuven Jhirad
Journal:  J Forensic Sci       Date:  2018-05-24       Impact factor: 1.832

3.  A suicide involving intraperitoneal injection of pentobarbital.

Authors:  Sarah Hangartner; Jasmin Steiner; Franz Dussy; Regula Moeckli; Kathrin Gerlach; Thomas Briellmann
Journal:  Int J Legal Med       Date:  2015-07-15       Impact factor: 2.686

4.  Postmortem computed tomography and magnetic resonance imaging facilitates forensic autopsy in a fatal case of poisoning with formic acid, diphenhydramine, and ethanol.

Authors:  Florian Berger; Andrea E Steuer; Katharina Rentsch; Dominic Gascho; Stamatios Stamou; Sarah Schärli; Michael J Thali; Thomas Krämer; Patricia M Flach
Journal:  Forensic Sci Med Pathol       Date:  2016-07-18       Impact factor: 2.007

5.  Distribution of veterinarian barbiturate preparations in human subjects.

Authors:  R F Shaw
Journal:  Clin Toxicol       Date:  1981-08       Impact factor: 4.467

  7 in total

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