Raul Zamora-Ros1, Valerie Cayssials2,3,4, Ramon Clèries5,6, Maria Torrents2, Graham Byrnes7, Elisabete Weiderpass7, Maria Sandström8, Martin Almquist9, Marie-Christine Boutron-Ruault10,11, Anne Tjønneland12,13, Cecilie Kyrø12, Verena A Katzke14, Charlotte Le Cornet14, Giovanna Masala15, Vittorio Krogh16, Gabriella Iannuzzo17, Rosario Tumino18, Lorenzo Milani19, Guri Skeie20, Esther Ubago-Guisado21,22,23, Pilar Amiano23,24, María-Dolores Chirlaque23,25, Eva Ardanaz23,26,27, Suzanne Janzi28, Linda Eriksson29, Heinz Freisling7, Alicia K Heath30, Sabina Rinaldi7, Antonio Agudo2. 1. Unit of Nutrition and Cancer, Epidemiology Research Program, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat (Barcelona) , Av Gran Via 199-203, 08908, Barcelona, Spain. rzamora@idibell.cat. 2. Unit of Nutrition and Cancer, Epidemiology Research Program, Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat (Barcelona) , Av Gran Via 199-203, 08908, Barcelona, Spain. 3. Department of Veterinary Public Health, Faculty of Veterinary, University of the Republic, Montevideo, Uruguay. 4. Department of Quantitative Methods, Faculty of Medicine, University of the Republic, Montevideo, Uruguay. 5. Pla Director d'Oncologia, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat (Barcelona),, Barcelona, Spain. 6. Department of Clinical Sciences, University of Barcelona, Barcelona, Spain. 7. International Agency for Research On Cancer (IARC-WHO), Lyon, France. 8. Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden. 9. Department of Surgery, Skåne University Hospital Malmö, Lund University, Lund, Sweden. 10. Centre for Research in Epidemiology and Population Health (CESP), Université Paris-Saclay, Université Paris-Sud, INSERM U1018, Villejuif, France. 11. Institut Gustave Roussy, Villejuif, France. 12. Danish Cancer Society Research Center, Copenhagen, Denmark. 13. Department of Public Health, University of Copenhagen, Copenhagen, Denmark. 14. Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. 15. Clinical Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network - ISPRO, Florence, Italy. 16. Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milan, Italy. 17. Dipartimento Di Medicina Clinica E Chirurgia, Federico II University, Naples, Italy. 18. AIRE - ONLUS, Hyblean Association for Epidemiological Research, Ragusa, Italy. 19. Cancer Epidemiology Unit, Department of Medical Sciences, University of Turin, Turin, Italy. 20. Department of Community Medicine, UiT the Arctic University of Norway, Tromsø, Norway. 21. Escuela Andaluza de Salud Pública (EASP), Granada, Spain. 22. Instituto de Investigación Biosanitaria Ibs.GRANADA, Granada, Spain. 23. CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain. 24. Sub Directorate for Public Health and Addictions of Gipuzkoa, Ministry of Health of the Basque Government, Biodonostia Health Research Institute, San Sebastian, Spain. 25. Department of Epidemiology, IMIB-Arrixaca, Murcia Regional Health Council, Murcia University, Murcia, Spain. 26. Navarra Public Health Institute, Pamplona, Spain. 27. IdiSNA, Navarra Institute for Health Research, Pamplona, Spain. 28. Department of Clinical Sciences, Faculty of Medicine, Lund University, Malmö, Sweden. 29. Department of Odontology, Umeå University, Umeå, Sweden. 30. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Abstract
BACKGROUND: Dietary pattern analysis has gained particular interest, because it reflects the complexity of dietary intake. The aim of this study was to explore the associations between a posteriori dietary patterns, derived using a data-driven approach, and the risk of differentiated thyroid cancer (TC) in Europe. METHODS: This investigation included 450,064 adults from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Dietary intake was assessed using validated country-specific dietary questionnaires. A posteriori dietary patterns were computed using principal component analyses. Cox regression was used to calculate multivariable adjusted hazard ratios (HRs) and 95% confidence intervals (CIs). RESULTS: After a mean follow-up time of 14 years, 712 first differentiated TCs were diagnosed. In the fully adjusted model, a dietary pattern characterized by alcohol consumption (basically beer and wine) was negatively associated with differentiated TC risk (HRQ4vs.Q1 = 0.75; 95% CI:0.60-0.94, P-trend = 0.005), while a dietary pattern rich in sweetened beverages was positively associated with differentiated TC risk (HRQ4vs.Q1 = 1.26; 95% CI:0.99-1.61; P-trend = 0.07). The remaining 8 dietary patterns were not related to differentiated TC risk. The intake of sweetened beverages was positively associated with differentiated TC risk (HR100mL/d = 1.05; 95% CI:1.00-1.11), especially with papillary TC risk (HR100mL/d = 1.07; 95% CI:1.01-1.13). Similar results were observed with sugary and artificially sweetened beverages. CONCLUSIONS: The investigation of dietary patterns detected that the consumption of sweetened beverages was associated with a higher risk of differentiated thyroid cancer. Our results are in line with the general dietary recommendations of reducing the consumption of sweetened beverages.
BACKGROUND: Dietary pattern analysis has gained particular interest, because it reflects the complexity of dietary intake. The aim of this study was to explore the associations between a posteriori dietary patterns, derived using a data-driven approach, and the risk of differentiated thyroid cancer (TC) in Europe. METHODS: This investigation included 450,064 adults from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Dietary intake was assessed using validated country-specific dietary questionnaires. A posteriori dietary patterns were computed using principal component analyses. Cox regression was used to calculate multivariable adjusted hazard ratios (HRs) and 95% confidence intervals (CIs). RESULTS: After a mean follow-up time of 14 years, 712 first differentiated TCs were diagnosed. In the fully adjusted model, a dietary pattern characterized by alcohol consumption (basically beer and wine) was negatively associated with differentiated TC risk (HRQ4vs.Q1 = 0.75; 95% CI:0.60-0.94, P-trend = 0.005), while a dietary pattern rich in sweetened beverages was positively associated with differentiated TC risk (HRQ4vs.Q1 = 1.26; 95% CI:0.99-1.61; P-trend = 0.07). The remaining 8 dietary patterns were not related to differentiated TC risk. The intake of sweetened beverages was positively associated with differentiated TC risk (HR100mL/d = 1.05; 95% CI:1.00-1.11), especially with papillary TC risk (HR100mL/d = 1.07; 95% CI:1.01-1.13). Similar results were observed with sugary and artificially sweetened beverages. CONCLUSIONS: The investigation of dietary patterns detected that the consumption of sweetened beverages was associated with a higher risk of differentiated thyroid cancer. Our results are in line with the general dietary recommendations of reducing the consumption of sweetened beverages.
Authors: Raul Zamora-Ros; Muath A Alghamdi; Valerie Cayssials; Silvia Franceschi; Martin Almquist; Joakim Hennings; Maria Sandström; Konstantinos K Tsilidis; Elisabete Weiderpass; Marie-Christine Boutron-Ruault; Bodil Hammer Bech; Kim Overvad; Anne Tjønneland; Kristina E N Petersen; Francesca Romana Mancini; Yahya Mahamat-Saleh; Fabrice Bonnet; Tilman Kühn; Renée T Fortner; Heiner Boeing; Antonia Trichopoulou; Christina Bamia; Georgia Martimianaki; Giovanna Masala; Sara Grioni; Salvatore Panico; Rosario Tumino; Francesca Fasanelli; Guri Skeie; Tonje Braaten; Cristina Lasheras; Elena Salamanca-Fernández; Pilar Amiano; Maria-Dolores Chirlaque; Aurelio Barricarte; Jonas Manjer; Peter Wallström; H Bas Bueno-de-Mesquita; Petra H Peeters; Kay-Thee Khaw; Nicholas J Wareham; Julie A Schmidt; Dagfinn Aune; Graham Byrnes; Augustin Scalbert; Antonio Agudo; Sabina Rinaldi Journal: Eur J Nutr Date: 2018-12-10 Impact factor: 5.614
Authors: Salvatore Vaccarella; Silvia Franceschi; Freddie Bray; Christopher P Wild; Martyn Plummer; Luigino Dal Maso Journal: N Engl J Med Date: 2016-08-18 Impact factor: 91.245
Authors: Raul Zamora-Ros; Virginie Béraud; Silvia Franceschi; Valerie Cayssials; Konstantinos K Tsilidis; Marie-Christine Boutron-Ruault; Elisabete Weiderpass; Kim Overvad; Anne Tjønneland; Anne K Eriksen; Fabrice Bonnet; Aurélie Affret; Verena Katzke; Tilman Kühn; Heiner Boeing; Antonia Trichopoulou; Elisavet Valanou; Anna Karakatsani; Giovanna Masala; Sara Grioni; Maria Santucci de Magistris; Rosario Tumino; Fulvio Ricceri; Guri Skeie; Christine L Parr; Susana Merino; Elena Salamanca-Fernández; Maria-Dolores Chirlaque; Eva Ardanaz; Pilar Amiano; Martin Almquist; Isabel Drake; Joakim Hennings; Maria Sandström; H B As Bueno-de-Mesquita; Petra H Peeters; Kay-Thee Khaw; Nicholas J Wareham; Julie A Schmidt; Aurora Perez-Cornago; Dagfinn Aune; Elio Riboli; Nadia Slimani; Augustin Scalbert; Isabelle Romieu; Antonio Agudo; Sabina Rinaldi Journal: Int J Cancer Date: 2017-07-24 Impact factor: 7.396
Authors: Freddie Bray; Jacques Ferlay; Isabelle Soerjomataram; Rebecca L Siegel; Lindsey A Torre; Ahmedin Jemal Journal: CA Cancer J Clin Date: 2018-09-12 Impact factor: 508.702
Authors: Abhijit Sen; Konstantinos K Tsilidis; Naomi E Allen; Sabina Rinaldi; Paul N Appleby; Martin Almquist; Julie A Schmidt; Christina C Dahm; Kim Overvad; Anne Tjønneland; Agnetha L Rostgaard-Hansen; Françoise Clavel-Chapelon; Laura Baglietto; Marie-Christine Boutron-Ruault; Tilman Kühn; Verena A Katze; Heiner Boeing; Antonia Trichopoulou; Christos Tsironis; Pagona Lagiou; Domenico Palli; Valeria Pala; Salvatore Panico; Rosario Tumino; Paolo Vineis; Hb As Bueno-de-Mesquita; Petra H Peeters; Anette Hjartåker; Eiliv Lund; Elisabete Weiderpass; J Ramón Quirós; Antonio Agudo; María-José Sánchez; Larraitz Arriola; Diana Gavrila; Aurelio Barricarte Gurrea; Ada Tosovic; Joakim Hennings; Maria Sandström; Isabelle Romieu; Pietro Ferrari; Raul Zamora-Ros; Kay-Tee Khaw; Nicholas J Wareham; Elio Riboli; Marc Gunter; Silvia Franceschi Journal: Br J Cancer Date: 2015-08-27 Impact factor: 7.640