Literature DB >> 35906930

Correlation between post-vaccination anti-Spike antibody titres and protection against breakthrough SARS-CoV-2 infection: a population-based longitudinal study.

Giulia Vivaldi1,2, David A Jolliffe1,2, Sian Faustini3, Adrian M Shields3, Hayley Holt1,2,4, Natalia Perdek1, Mohammad Talaei2, Florence Tydeman1,2, Emma S Chambers1, Weigang Cai1, Wenhao Li1, Joseph M Gibbons1, Corinna Pade1, Áine McKnight1, Seif O Shaheen2, Alex G Richter3, Adrian R Martineau1,2,4.   

Abstract

In this population-based cohort of 7538 adults, combined IgG/A/M anti-Spike titres measured after SARS-CoV-2 vaccination were predictive of protection against breakthrough SARS-CoV-2 infection. Discrimination was significantly improved by adjustment for factors influencing risk of SARS-CoV-2 exposure, including household overcrowding, public transport use, and visits to indoor public places. Anti-Spike IgG/A/M titres showed positive correlation with neutralising antibody titres (r-s = 0.80, 95% CI 0.72-0.86; p < 0.0001) and S peptide-stimulated interferon-γ concentrations (r-s = 0.31, 0.13-0.47; p = 0.0009).
© The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Entities:  

Keywords:  SARS-CoV-2; breakthrough infection; combined antibody response; vaccination

Year:  2022        PMID： 35906930      PMCID： PMC9384605          DOI： 10.1093/infdis/jiac321

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   7.759


  15 in total

1.  Heterologous infection and vaccination shapes immunity against SARS-CoV-2 variants.

Authors:  Catherine J Reynolds; Joseph M Gibbons; Corinna Pade; Áine McKnight; Daniel M Altmann; Rosemary J Boyton; Kai-Min Lin; Diana Muñoz Sandoval; Franziska Pieper; David K Butler; Siyi Liu; Ashley D Otter; George Joy; Katia Menacho; Marianna Fontana; Angelique Smit; Beatrix Kele; Teresa Cutino-Moguel; Mala K Maini; Mahdad Noursadeghi; Tim Brooks; Amanda Semper; Charlotte Manisty; Thomas A Treibel; James C Moon
Journal:  Science       Date:  2021-12-02       Impact factor: 47.728

2.  Differential immunogenicity of BNT162b2 or ChAdOx1 vaccines after extended-interval homologous dual vaccination in older people.

Authors:  Helen Parry; Rachel Bruton; Christine Stephens; Kevin Brown; Gayatri Amirthalingam; Ashley Otter; Bassam Hallis; Jianmin Zuo; Paul Moss
Journal:  Immun Ageing       Date:  2021-08-20       Impact factor: 6.400

3.  SARS-CoV-2 vaccination elicits unconventional IgM specific responses in naïve and previously COVID-19-infected individuals.

Authors:  Alessandra Ruggiero; Chiara Piubelli; Lucia Calciano; Simone Accordini; Maria Teresa Valenti; Luca Dalle Carbonare; Gabriel Siracusano; Nigel Temperton; Natalia Tiberti; Silvia Stefania Longoni; Massimo Pizzato; Silvia Accordini; Tobia Fantoni; Lucia Lopalco; Alberto Beretta; Zeno Bisoffi; Donato Zipeto
Journal:  EBioMedicine       Date:  2022-02-20       Impact factor: 8.143

4.  Neutralising antibody titres as predictors of protection against SARS-CoV-2 variants and the impact of boosting: a meta-analysis.

Authors:  Deborah Cromer; Megan Steain; Arnold Reynaldi; Timothy E Schlub; Adam K Wheatley; Jennifer A Juno; Stephen J Kent; James A Triccas; David S Khoury; Miles P Davenport
Journal:  Lancet Microbe       Date:  2021-11-15

5.  Towards a population-based threshold of protection for COVID-19 vaccines.

Authors:  David Goldblatt; Andrew Fiore-Gartland; Marina Johnson; Adam Hunt; Christopher Bengt; Dace Zavadska; Hilda Darta Snipe; Jeremy S Brown; Lesley Workman; Heather J Zar; David Montefiori; Xiaoying Shen; Peter Dull; Stanley Plotkin; George Siber; Donna Ambrosino
Journal:  Vaccine       Date:  2021-12-15       Impact factor: 3.641

6.  T-cell and antibody responses to first BNT162b2 vaccine dose in previously infected and SARS-CoV-2-naive UK health-care workers: a multicentre prospective cohort study.

Authors:  Adrienn Angyal; Stephanie Longet; Shona C Moore; Rebecca P Payne; Adam Harding; Tom Tipton; Patpong Rongkard; Mohammad Ali; Luisa M Hering; Naomi Meardon; James Austin; Rebecca Brown; Donal Skelly; Natalie Gillson; Sue L Dobson; Andrew Cross; Gurjinder Sandhar; Jonathan A Kilby; Jessica K Tyerman; Alexander R Nicols; Jarmila S Spegarova; Hema Mehta; Hailey Hornsby; Rachel Whitham; Christopher P Conlon; Katie Jeffery; Philip Goulder; John Frater; Christina Dold; Matthew Pace; Ane Ogbe; Helen Brown; M Azim Ansari; Emily Adland; Anthony Brown; Meera Chand; Adrian Shields; Philippa C Matthews; Susan Hopkins; Victoria Hall; William James; Sarah L Rowland-Jones; Paul Klenerman; Susanna Dunachie; Alex Richter; Christopher J A Duncan; Eleanor Barnes; Miles Carroll; Lance Turtle; Thushan I de Silva
Journal:  Lancet Microbe       Date:  2021-11-09

7.  Immune correlates analysis of the mRNA-1273 COVID-19 vaccine efficacy clinical trial.

Authors:  Peter B Gilbert; David C Montefiori; Adrian B McDermott; Ruben O Donis; Richard A Koup; Youyi Fong; David Benkeser; Weiping Deng; Honghong Zhou; Christopher R Houchens; Karen Martins; Lakshmi Jayashankar; Flora Castellino; Britta Flach; Bob C Lin; Sarah O'Connell; Charlene McDanal; Amanda Eaton; Marcella Sarzotti-Kelsoe; Yiwen Lu; Chenchen Yu; Bhavesh Borate; Lars W P van der Laan; Nima S Hejazi; Chuong Huynh; Jacqueline Miller; Hana M El Sahly; Lindsey R Baden; Mira Baron; Luis De La Cruz; Cynthia Gay; Spyros Kalams; Colleen F Kelley; Michele P Andrasik; James G Kublin; Lawrence Corey; Kathleen M Neuzil; Lindsay N Carpp; Rolando Pajon; Dean Follmann
Journal:  Science       Date:  2021-11-23       Impact factor: 63.714

Review 8.  Immunoglobulin M: An Ancient Antiviral Weapon - Rediscovered.

Authors:  Siqi Gong; Ruth M Ruprecht
Journal:  Front Immunol       Date:  2020-08-11       Impact factor: 7.561

9.  Discordant neutralizing antibody and T cell responses in asymptomatic and mild SARS-CoV-2 infection.

Authors:  Catherine J Reynolds; Leo Swadling; Joseph M Gibbons; Corinna Pade; Melanie P Jensen; Mariana O Diniz; Nathalie M Schmidt; David K Butler; Oliver E Amin; Sasha N L Bailey; Sam M Murray; Franziska P Pieper; Stephen Taylor; Jessica Jones; Meleri Jones; Wing-Yiu Jason Lee; Joshua Rosenheim; Aneesh Chandran; George Joy; Cecilia Di Genova; Nigel Temperton; Jonathan Lambourne; Teresa Cutino-Moguel; Mervyn Andiapen; Marianna Fontana; Angelique Smit; Amanda Semper; Ben O'Brien; Benjamin Chain; Tim Brooks; Charlotte Manisty; Thomas Treibel; James C Moon; Mahdad Noursadeghi; Daniel M Altmann; Mala K Maini; Áine McKnight; Rosemary J Boyton
Journal:  Sci Immunol       Date:  2020-12-23

10.  Correlates of protection against symptomatic and asymptomatic SARS-CoV-2 infection.

Authors:  Teresa Lambe; Andrew J Pollard; Merryn Voysey; Shuo Feng; Daniel J Phillips; Thomas White; Homesh Sayal; Parvinder K Aley; Sagida Bibi; Christina Dold; Michelle Fuskova; Sarah C Gilbert; Ian Hirsch; Holly E Humphries; Brett Jepson; Elizabeth J Kelly; Emma Plested; Kathryn Shoemaker; Kelly M Thomas; Johan Vekemans; Tonya L Villafana
Journal:  Nat Med       Date:  2021-09-29       Impact factor: 53.440
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