Ekta Kapoor1, Stephanie S Faubion2, Liliana Gazzuola Rocca3, Michelle M Mielke4, Carin Y Smith5, Walter A Rocca4. 1. Menopause and Women's Sexual Health Clinic, Division of General Internal Medicine, Mayo Clinic, Rochester, MN, United States; Division of Endocrinology, Diabetes, Metabolism and Nutrition, Mayo Clinic, Rochester, MN, United States; Center for Women's Health, Mayo Clinic, Rochester, MN, United States; Mayo Clinic Specialized Center of Research Excellence (SCORE) on Sex Differences, Mayo Clinic, Rochester, MN, United States. Electronic address: kapoor.ekta@mayo.edu. 2. Center for Women's Health, Mayo Clinic, Rochester, MN, United States; Division of General Internal Medicine, Mayo Clinic, Jacksonville, FL, United States. 3. Division of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, United States. 4. Mayo Clinic Specialized Center of Research Excellence (SCORE) on Sex Differences, Mayo Clinic, Rochester, MN, United States; Division of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, United States; Department of Neurology, Mayo Clinic, Rochester, MN, United States. 5. Division of Clinical Trials and Biostatistics, Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, United States.
Abstract
OBJECTIVE: To study the trajectories of metabolic parameters after bilateral oophorectomy. STUDY DESIGN: This population-based cohort study included a random sample of all premenopausal women who underwent bilateral oophorectomy at or before age 45 years from 1988 to 2007 in Olmsted County, Minnesota, and their age-matched (±1 year) referent women who did not undergo bilateral oophorectomy. MAIN OUTCOME MEASURES: The medical records of all women were reviewed to collect the metabolic parameters over a 10-year period. We compared three groups of women: 1) referent women (n = 270), 2) women who underwent bilateral oophorectomy and received estrogen therapy (n = 163), and 3) women who underwent bilateral oophorectomy and did not receive estrogen therapy (n = 107). RESULTS: Over 10 years of follow-up, the three groups had significantly different mean values of diastolic blood pressure, weight, body mass index (BMI), total cholesterol, triglycerides, and high-density lipoprotein cholesterol (HDL-C). However, women with and without bilateral oophorectomy were already different at baseline for hyperlipidemia, systolic blood pressure, weight, and BMI. Nevertheless, the trajectories of change over 10 years were significant for weight (group by time interaction p = 0.03), BMI (p = 0.03), and HDL-C (p = 0.004). The changes occurred primarily in the initial 4-5 years. Women who received estrogen therapy after bilateral oophorectomy were comparable to the referent women with respect to the weight and BMI trends, and they experienced an increase in HDL-C over time. CONCLUSION: Women who underwent bilateral oophorectomy before menopause experienced unfavorable changes in some metabolic parameters possibly increasing their cardiovascular risk.
OBJECTIVE: To study the trajectories of metabolic parameters after bilateral oophorectomy. STUDY DESIGN: This population-based cohort study included a random sample of all premenopausal women who underwent bilateral oophorectomy at or before age 45 years from 1988 to 2007 in Olmsted County, Minnesota, and their age-matched (±1 year) referent women who did not undergo bilateral oophorectomy. MAIN OUTCOME MEASURES: The medical records of all women were reviewed to collect the metabolic parameters over a 10-year period. We compared three groups of women: 1) referent women (n = 270), 2) women who underwent bilateral oophorectomy and received estrogen therapy (n = 163), and 3) women who underwent bilateral oophorectomy and did not receive estrogen therapy (n = 107). RESULTS: Over 10 years of follow-up, the three groups had significantly different mean values of diastolic blood pressure, weight, body mass index (BMI), total cholesterol, triglycerides, and high-density lipoprotein cholesterol (HDL-C). However, women with and without bilateral oophorectomy were already different at baseline for hyperlipidemia, systolic blood pressure, weight, and BMI. Nevertheless, the trajectories of change over 10 years were significant for weight (group by time interaction p = 0.03), BMI (p = 0.03), and HDL-C (p = 0.004). The changes occurred primarily in the initial 4-5 years. Women who received estrogen therapy after bilateral oophorectomy were comparable to the referent women with respect to the weight and BMI trends, and they experienced an increase in HDL-C over time. CONCLUSION: Women who underwent bilateral oophorectomy before menopause experienced unfavorable changes in some metabolic parameters possibly increasing their cardiovascular risk.
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Authors: Walter A Rocca; Liliana Gazzuola Rocca; Carin Y Smith; Brandon R Grossardt; Stephanie S Faubion; Lynne T Shuster; Elizabeth A Stewart; Michelle M Mielke; Kejal Kantarci; Virginia M Miller Journal: BMJ Open Date: 2017-11-20 Impact factor: 2.692
Authors: Walter A Rocca; Liliana Gazzuola-Rocca; Carin Y Smith; Brandon R Grossardt; Stephanie S Faubion; Lynne T Shuster; James L Kirkland; Elizabeth A Stewart; Virginia M Miller Journal: Mayo Clin Proc Date: 2016-09-29 Impact factor: 7.616