Literature DB >> 359051

Codon-specific interaction of uncharged transfer-RNA with eukaryotic ribosomes.

M J Murchie, D P Leader.   

Abstract

Rat liver ribosomes bound [32P]tRNAPhe in both a codon-dependent and codon-independent manner. The codon-dependent binding was studied further by utilising the ability of the unchanged tRNAPhe to inhibit the poly(U)-directed binding of [3H]Phe-tRNA to ribosomes. At least part of the codon-dependent binding of uncharged tRNA appears to be to the ribosomal A-site.

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Year:  1978        PMID： 359051     DOI： 10.1016/0005-2787(78)90024-2

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  5 in total

1.  Evidence that eukaryotic translation elongation factor 1A (eEF1A) binds the Gcn2 protein C terminus and inhibits Gcn2 activity.

Authors:  Jyothsna Visweswaraiah; Sebastien Lageix; Beatriz A Castilho; Lara Izotova; Terri Goss Kinzy; Alan G Hinnebusch; Evelyn Sattlegger
Journal:  J Biol Chem       Date:  2011-08-17       Impact factor: 5.157

2.  Separate domains in GCN1 for binding protein kinase GCN2 and ribosomes are required for GCN2 activation in amino acid-starved cells.

Authors:  E Sattlegger; A G Hinnebusch
Journal:  EMBO J       Date:  2000-12-01       Impact factor: 11.598

3.  Overexpression of eukaryotic translation elongation factor 3 impairs Gcn2 protein activation.

Authors:  Jyothsna Visweswaraiah; Su Jung Lee; Alan G Hinnebusch; Evelyn Sattlegger
Journal:  J Biol Chem       Date:  2012-08-10       Impact factor: 5.157

4.  Activation of GCN2 kinase by ribosome stalling links translation elongation with translation initiation.

Authors:  Ryuta Ishimura; Gabor Nagy; Ivan Dotu; Jeffrey H Chuang; Susan L Ackerman
Journal:  Elife       Date:  2016-04-16       Impact factor: 8.140

5.  Amino acid deprivation triggers a novel GCN2-independent response leading to the transcriptional reactivation of non-native DNA sequences.

Authors:  Annarosaria De Vito; Massimo Lazzaro; Ilaria Palmisano; Davide Cittaro; Michela Riba; Dejan Lazarevic; Makoto Bannai; Davide Gabellini; Maria Vittoria Schiaffino
Journal:  PLoS One       Date:  2018-07-18       Impact factor: 3.240
  5 in total

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