Tak Kyu Oh1,2, In-Ae Song1,2, Hye Yoon Park3, Jung-Won Hwang4,5. 1. Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Gumi-ro, 173, Beon-gil, Bundang-gu, Seongnam, 13620, South Korea. 2. Department of Anesthesiology and Pain Medicine, College of Medicine, Seoul National University, Seoul, South Korea. 3. Department of Psychiatry, Seoul National University Bundang Hospital, Seongnam, South Korea. 4. Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Gumi-ro, 173, Beon-gil, Bundang-gu, Seongnam, 13620, South Korea. jungwon@snubh.org. 5. Department of Anesthesiology and Pain Medicine, College of Medicine, Seoul National University, Seoul, South Korea. jungwon@snubh.org.
Abstract
BACKGROUND: Esophageal cancer is believed to be related to psychological stress. This study aimed to examine the prevalence and risk factors for new-onset depression after esophageal cancer surgery among patients who had no pre-existing depression. In addition, we examined whether pre-existing depression affected postoperative 1-year mortality. METHODS: The National Health Insurance Service database in South Korea was used for data extraction in this population-based cohort study. This study included all adult patients diagnosed with esophageal cancer who underwent esophageal surgery between January 1, 2011, and December 31, 2018. RESULTS: A total of 7039 adult patients who underwent esophageal cancer surgery at 95 South Korean hospitals were included in the analyses. Of the total, 608 patients (8.6%) were diagnosed with new-onset depression within 1 year after esophageal cancer surgery. Female sex, adjuvant chemotherapy, increased Charlson comorbidity index, pre-existing anxiety disorder, and pre-existing insomnia disorder were potential risk factors for new-onset depression. In multivariable Cox regression analysis, the pre-existing depression group showed a 1.27-fold (hazard ratio: 1.27; 95% confidence interval: 1.08-1.48; P = 0.004) higher risk of 1-year all-cause mortality than those who had no pre-existing depression. CONCLUSION: In South Korea, 8.6% of patients are newly diagnosed with depression after esophageal cancer surgery, and some potential risk factors have been identified. Moreover, pre-existing depression was associated with increased 1-year all-cause mortality. Patients with esophageal cancer and pre-existing depression may be at high risk, requiring interventions after esophageal cancer surgery.
BACKGROUND: Esophageal cancer is believed to be related to psychological stress. This study aimed to examine the prevalence and risk factors for new-onset depression after esophageal cancer surgery among patients who had no pre-existing depression. In addition, we examined whether pre-existing depression affected postoperative 1-year mortality. METHODS: The National Health Insurance Service database in South Korea was used for data extraction in this population-based cohort study. This study included all adult patients diagnosed with esophageal cancer who underwent esophageal surgery between January 1, 2011, and December 31, 2018. RESULTS: A total of 7039 adult patients who underwent esophageal cancer surgery at 95 South Korean hospitals were included in the analyses. Of the total, 608 patients (8.6%) were diagnosed with new-onset depression within 1 year after esophageal cancer surgery. Female sex, adjuvant chemotherapy, increased Charlson comorbidity index, pre-existing anxiety disorder, and pre-existing insomnia disorder were potential risk factors for new-onset depression. In multivariable Cox regression analysis, the pre-existing depression group showed a 1.27-fold (hazard ratio: 1.27; 95% confidence interval: 1.08-1.48; P = 0.004) higher risk of 1-year all-cause mortality than those who had no pre-existing depression. CONCLUSION: In South Korea, 8.6% of patients are newly diagnosed with depression after esophageal cancer surgery, and some potential risk factors have been identified. Moreover, pre-existing depression was associated with increased 1-year all-cause mortality. Patients with esophageal cancer and pre-existing depression may be at high risk, requiring interventions after esophageal cancer surgery.
Authors: Tara R Semenkovich; Melanie Subramanian; Yan Yan; Wayne L Hofstetter; Arlene M Correa; Stephen D Cassivi; Matthew L Inra; Brendon M Stiles; Nasser K Altorki; Andrew C Chang; Alexander A Brescia; Gail E Darling; Frances Allison; Stephen R Broderick; Eric W Etchill; Felix G Fernandez; Ray K Chihara; Virginia R Litle; Juan A Muñoz-Largacha; Benjamin D Kozower; Varun Puri; Bryan F Meyers Journal: Ann Thorac Surg Date: 2019-06-20 Impact factor: 4.330
Authors: Stefan M Gold; Ole Köhler-Forsberg; Rona Moss-Morris; Anja Mehnert; J Jaime Miranda; Monika Bullinger; Andrew Steptoe; Mary A Whooley; Christian Otte Journal: Nat Rev Dis Primers Date: 2020-08-20 Impact factor: 52.329
Authors: Myrela O Machado; Nicola Veronese; Marcos Sanches; Brendon Stubbs; Ai Koyanagi; Trevor Thompson; Ioanna Tzoulaki; Marco Solmi; Davy Vancampfort; Felipe B Schuch; Michael Maes; Giovanni A Fava; John P A Ioannidis; André F Carvalho Journal: BMC Med Date: 2018-07-20 Impact factor: 8.775
Authors: Claire L Niedzwiedz; Lee Knifton; Kathryn A Robb; Srinivasa Vittal Katikireddi; Daniel J Smith Journal: BMC Cancer Date: 2019-10-11 Impact factor: 4.430