Literature DB >> 35903561

Renal Cell Carcinoma: A Complex Therapeutic Challenge in the Elderly.

Mashood Iqbal1.   

Abstract

An increase in age and the occurrence of renal cell carcinoma have been positively correlated. A strict therapeutic protocol for early diagnosis, screening, prevention, and population awareness needs to be well-established as a rationale to approach the morbidity at a treatment-eligible phase in the aged. Genetic predisposition appears to have a minor role in the disease pathology. Imaging modalities, providing high-resolution images of the tumor, have undoubtedly benefitted the diseased subset in aiding the diagnosis, however, a preliminary guideline protocol for its early implication in concordance with the initial symptoms needs to be adopted. Burdening of the geriatric age group by concomitant co-morbidities further deteriorates the devastating effects of the primary tumor, which, in total, appear to evolve as a final, complex stage of the illness in the majority, leading to an eventual high mortality rate. Despite being a challenging task for managing the tumor, age should not be considered the sole treatment barrier for approaching the disease.
Copyright © 2022, Iqbal et al.

Entities:  

Keywords:  elderly patients; genetic mutations; malignant tumor; mortality rate; older-aged patients; renal cell carcinoma (rcc); surgical removal

Year:  2022        PMID: 35903561      PMCID: PMC9321336          DOI: 10.7759/cureus.26346

Source DB:  PubMed          Journal:  Cureus        ISSN: 2168-8184


  34 in total

1.  Comparative Effectiveness of Thermal Ablation, Surgical Resection, and Active Surveillance for T1a Renal Cell Carcinoma: A Surveillance, Epidemiology, and End Results (SEER)-Medicare-linked Population Study.

Authors:  Minzhi Xing; Nima Kokabi; Di Zhang; Johannes M Ludwig; Hyun S Kim
Journal:  Radiology       Date:  2018-05-08       Impact factor: 11.105

2.  Renal cell carcinoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†.

Authors:  B Escudier; C Porta; M Schmidinger; N Rioux-Leclercq; A Bex; V Khoo; V Grünwald; S Gillessen; A Horwich
Journal:  Ann Oncol       Date:  2019-05-01       Impact factor: 32.976

3.  Patient-reported outcomes of patients with advanced renal cell carcinoma treated with nivolumab plus ipilimumab versus sunitinib (CheckMate 214): a randomised, phase 3 trial.

Authors:  David Cella; Viktor Grünwald; Bernard Escudier; Hans J Hammers; Saby George; Paul Nathan; Marc-Oliver Grimm; Brian I Rini; Justin Doan; Cristina Ivanescu; Jean Paty; Sabeen Mekan; Robert J Motzer
Journal:  Lancet Oncol       Date:  2019-01-15       Impact factor: 41.316

Review 4.  Renal cell carcinoma.

Authors:  Paul Cairns
Journal:  Cancer Biomark       Date:  2010       Impact factor: 4.388

5.  Cystic renal tumors: US and CT findings.

Authors:  L Dalla-Palma; F Pozzi-Mucelli; A di Donna; R S Pozzi-Mucelli
Journal:  Urol Radiol       Date:  1990

6.  Small renal cell carcinoma: pathologic and radiologic correlation.

Authors:  Y Yamashita; M Takahashi; O Watanabe; S Yoshimatsu; S Ueno; S Ishimaru; M Kan; S Takano; N Ninomiya
Journal:  Radiology       Date:  1992-08       Impact factor: 11.105

Review 7.  Renal Cell Carcinoma: Diagnosis and Management.

Authors:  Richard E Gray; Gabriel T Harris
Journal:  Am Fam Physician       Date:  2019-02-01       Impact factor: 3.292

Review 8.  Therapeutic challenges in renal cell carcinoma.

Authors:  Justin C Penticuff; Natasha Kyprianou
Journal:  Am J Clin Exp Urol       Date:  2015-08-08

Review 9.  Epidemiology of Renal Cell Carcinoma.

Authors:  Umberto Capitanio; Karim Bensalah; Axel Bex; Stephen A Boorjian; Freddie Bray; Jonathan Coleman; John L Gore; Maxine Sun; Christopher Wood; Paul Russo
Journal:  Eur Urol       Date:  2018-09-19       Impact factor: 20.096

Review 10.  Hereditary renal cell carcinoma syndromes: diagnosis, surveillance and management.

Authors:  Eamonn R Maher
Journal:  World J Urol       Date:  2018-04-21       Impact factor: 4.226

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