Stefan Begré1,2, Benjamin Misselwitz3, Sebastian Bruno Ulrich Jordi4,5,6, Brian Matthew Lang7, Jacqueline Wyss4,6, Bianca Auschra8, Bahtiyar Yilmaz4,6, Niklas Krupka4, Thomas Greuter5,9, Philipp Schreiner5, Luc Biedermann5, Martin Preisig10, Roland von Känel8, Gerhard Rogler5. 1. Neurology, Department of Biomedical Research, Bern University Hospital, University of Bern, Bern, Switzerland. 2. ISFOM-Institute of Stress Diseases and Stressmanagement, Zurich, Switzerland. 3. Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. benjamin.misselwitz@insel.ch. 4. Department of Visceral Surgery and Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. 5. Department of Gastroenterology and Hepatology, University Hospital Zurich and Zurich University, Zurich, Switzerland. 6. Department for Biomedical Research, Visceral Surgery and Medicine, Systems Biomedicine of Cellular Development and Signaling in Health and Disease, University of Bern, Bern, Switzerland. 7. Clinic for Transplantation Immunology and Nephrology (Swiss Transplant Cohort Study), University Hospital of Basel, Basel, Switzerland. 8. Department of Consultation-Liaison Psychiatry and Psychosomatic Medicine, University Hospital Zurich, University of Zurich, Zurich, Switzerland. 9. Division of Gastroenterology and Hepatology, University Hospital Lausanne-CHUV, Lausanne, Switzerland. 10. Department of Psychiatry, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Abstract
BACKGROUND: The bidirectional "gut-brain axis" has been implicated in the pathogenesis of inflammatory bowel diseases (IBD). While the influence of stress and depressive symptoms on IBD is well-characterized, the role of personality remains insufficiently investigated. METHODS: Personality was assessed in 1154 Swiss IBD cohort study (SIBDCS) patients via the NEO-Five-Factor Inventory (NEO-FFI) as well as in 2600 participants of the population-based CoLaus¦PsyCoLaus cohort study (NEO-FFI-revised). The NEO-FFI subcomponents activity, self-reproach and negative affect were associated with higher IBD disease activity and were combined to a NEO-FFI risk score. This risk score was validated and its effect on clinical IBD course and psychological endpoints was analysed in time-to-event and cumulative incidence analyses. RESULTS: In time-to-event analyses, a high NEO-FFI risk score was predictive for the clinical endpoints of new extraintestinal manifestation [EIM, adjusted hazard ratio (aHR) = 1.64, corrected p value (q) = 0.036] and two established composite flare endpoints (aHR = 1.53-1.63, q = 0.003-0.006) as well as for the psychological endpoints depressive symptoms (aHR = 7.06, q < 0.001) and low quality of life (aHR = 3.06, q < 0.001). Furthermore, cumulative incidence analyses showed that patients at high NEO-FFI risk experienced significantly more episodes of active disease, new EIMs, one of the flare endpoints, depressive episodes and low disease-related quality of life. Personalities of IBD patients showed only minor differences from the general population sample (Pearson's r = 0.03-0.14). CONCLUSIONS: Personality assessed by the NEO-FFI contained considerable predictive power for disease recurrence, depressive symptoms and low quality of life in IBD patients. Nevertheless, the personalities of IBD patients did not substantially differ from the general population.
BACKGROUND: The bidirectional "gut-brain axis" has been implicated in the pathogenesis of inflammatory bowel diseases (IBD). While the influence of stress and depressive symptoms on IBD is well-characterized, the role of personality remains insufficiently investigated. METHODS: Personality was assessed in 1154 Swiss IBD cohort study (SIBDCS) patients via the NEO-Five-Factor Inventory (NEO-FFI) as well as in 2600 participants of the population-based CoLaus¦PsyCoLaus cohort study (NEO-FFI-revised). The NEO-FFI subcomponents activity, self-reproach and negative affect were associated with higher IBD disease activity and were combined to a NEO-FFI risk score. This risk score was validated and its effect on clinical IBD course and psychological endpoints was analysed in time-to-event and cumulative incidence analyses. RESULTS: In time-to-event analyses, a high NEO-FFI risk score was predictive for the clinical endpoints of new extraintestinal manifestation [EIM, adjusted hazard ratio (aHR) = 1.64, corrected p value (q) = 0.036] and two established composite flare endpoints (aHR = 1.53-1.63, q = 0.003-0.006) as well as for the psychological endpoints depressive symptoms (aHR = 7.06, q < 0.001) and low quality of life (aHR = 3.06, q < 0.001). Furthermore, cumulative incidence analyses showed that patients at high NEO-FFI risk experienced significantly more episodes of active disease, new EIMs, one of the flare endpoints, depressive episodes and low disease-related quality of life. Personalities of IBD patients showed only minor differences from the general population sample (Pearson's r = 0.03-0.14). CONCLUSIONS: Personality assessed by the NEO-FFI contained considerable predictive power for disease recurrence, depressive symptoms and low quality of life in IBD patients. Nevertheless, the personalities of IBD patients did not substantially differ from the general population.
Authors: Sebastian Bruno Ulrich Jordi; Federica Botte; Brian Matthew Lang; Thomas Greuter; Niklas Krupka; Bianca Auschra; Philipp Schreiner; Michael Christian Sulz; Luc Biedermann; Roland von Känel; Gerhard Rogler; Stefan Begré; Benjamin Misselwitz Journal: Aliment Pharmacol Ther Date: 2021-05-11 Impact factor: 8.171
Authors: Rafael J A Cámara; Paul S Lukas; Stefan Begré; Valérie Pittet; Roland von Känel Journal: Inflamm Bowel Dis Date: 2010-10-25 Impact factor: 5.325
Authors: John F Cryan; Kenneth J O'Riordan; Caitlin S M Cowan; Kiran V Sandhu; Thomaz F S Bastiaanssen; Marcus Boehme; Martin G Codagnone; Sofia Cussotto; Christine Fulling; Anna V Golubeva; Katherine E Guzzetta; Minal Jaggar; Caitriona M Long-Smith; Joshua M Lyte; Jason A Martin; Alicia Molinero-Perez; Gerard Moloney; Emanuela Morelli; Enrique Morillas; Rory O'Connor; Joana S Cruz-Pereira; Veronica L Peterson; Kieran Rea; Nathaniel L Ritz; Eoin Sherwin; Simon Spichak; Emily M Teichman; Marcel van de Wouw; Ana Paula Ventura-Silva; Shauna E Wallace-Fitzsimons; Niall Hyland; Gerard Clarke; Timothy G Dinan Journal: Physiol Rev Date: 2019-10-01 Impact factor: 37.312