Literature DB >> 35898361

Geller Syndrome: A Rare Cause of Persistent Hypokalemia During Pregnancy.

Naif Hindosh1, Rand Hindosh1, Bolanle Dada1, Swomya Bal2.   

Abstract

Geller syndrome is a rare disease and part of Mendelian forms of hypertension. This syndrome is caused by a mutation in the mineralocorticoid receptor with a resultant gain of function. It is characterized by hypertension and hypokalemia, which is exacerbated by the effect of progesterone and thereby presenting during pregnancy. Our patient is a 22-year-old female diagnosed with preeclampsia who presented with hypokalemia, refractory to treatment toward the end of her third trimester. The patient's hypokalemia resolved once she delivered her infant. Genetic testing is available, which can confirm the diagnosis of Geller syndrome. The management is supportive therapy and requires close monitoring of the patient and her fetus. Delivery of the fetus results in the resolution of both hypertension and hypokalemia.
Copyright © 2022, Hindosh et al.

Entities:  

Keywords:  geller syndrome; liddle syndrome; monogenic disorders; pre-eclampsia; recurrent hypokalemia; refractory hypokalemia

Year:  2022        PMID: 35898361      PMCID: PMC9308893          DOI: 10.7759/cureus.26272

Source DB:  PubMed          Journal:  Cureus        ISSN: 2168-8184


  7 in total

1.  Pregnancy Complicated by Hypertension and Hypokalemia.

Authors:  Arvind Kumar Garg; Priyanka Parajuli; Chaitanya Kumar Mamillapalli
Journal:  Am J Kidney Dis       Date:  2020-10       Impact factor: 8.860

2.  Bartter and Gitelman syndromes: Spectrum of clinical manifestations caused by different mutations.

Authors:  Amar Al Shibli; Hassib Narchi
Journal:  World J Methodol       Date:  2015-06-26

3.  Activating mineralocorticoid receptor mutation in hypertension exacerbated by pregnancy.

Authors:  D S Geller; A Farhi; N Pinkerton; M Fradley; M Moritz; A Spitzer; G Meinke; F T Tsai; P B Sigler; R P Lifton
Journal:  Science       Date:  2000-07-07       Impact factor: 47.728

4.  The severe form of hypertension caused by the activating S810L mutation in the mineralocorticoid receptor is cortisone related.

Authors:  Marie-Edith Rafestin-Oblin; Anny Souque; Brigitte Bocchi; Gregory Pinon; Jerome Fagart; Alain Vandewalle
Journal:  Endocrinology       Date:  2003-02       Impact factor: 4.736

Review 5.  Overview of Monogenic or Mendelian Forms of Hypertension.

Authors:  Rupesh Raina; Vinod Krishnappa; Abhijit Das; Harshesh Amin; Yeshwanter Radhakrishnan; Nikhil R Nair; Kirsten Kusumi
Journal:  Front Pediatr       Date:  2019-07-01       Impact factor: 3.418

6.  A Rare Cause of Chronic Hypokalemia with Metabolic Alkalosis: Case Report and Differential Diagnosis.

Authors:  Cristina Bertulli; Marguerite Hureaux; Chiara De Mutiis; Andrea Pasini; Detlef Bockenhauer; Rosa Vargas-Poussou; Claudio La Scola
Journal:  Children (Basel)       Date:  2020-11-05

7.  A Case Report of Recurrent Hypokalemia During Pregnancies Associated With Nonaldosterone-Mediated Renal Potassium Loss.

Authors:  Pairach Pintavorn; Stephanie Munie
Journal:  Can J Kidney Health Dis       Date:  2021-05-28
  7 in total

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