Literature DB >> 35897077

Correction: Overexpressing TGF-β1 in mesenchymal stem cells attenuates organ dysfunction during CLP-induced septic mice by reducing macrophage-driven.

Feng Liu1, Jianfeng Xie2, Xiwen Zhang1, Zongsheng Wu1, Shi Zhang1, Ming Xue1, Jianxiao Chen1, Yi Yang1, Haibo Qiu1.   

Abstract

Entities:  

Year:  2022        PMID: 35897077      PMCID: PMC9327333          DOI: 10.1186/s13287-022-03078-6

Source DB:  PubMed          Journal:  Stem Cell Res Ther        ISSN: 1757-6512            Impact factor:   8.079


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Correction to: Stem Cell Research & Therapy (2020) 11:378 https://doi.org/10.1186/s13287-020-01894-2 The original article [1] contains a number of errors which the authors would like to clarify: Following publication of the original article [1], the authors identified an incorrect image in Fig. 3. Correction made is listed below.
Fig. 3

Effect of MSC-TGF-β1 on inflammatory cytokines in the plasma and macrophages in tissue. a, b, c: The levels of IL-6, IL-1β, and IL-10 in the plasma were tested by ELISA (n = 3, *p < 0.05 vs. the sham group; #p < 0.05 vs. the CLP group; &p < 0.05 vs. the MSC-NC group). d, e, f: The levels of macrophages in lung, liver and spleen tissue were assayed by immumohistochemical staining. (n = 3, *p < 0.05 vs. the sham group; #p < 0.05 vs. the CLP group; &p < 0.05 vs. the MSC-NC group). Scale bar = 100 μm. Abbreviations: CLP: cecal ligation and puncture; MSCs, mesenchymal stem cells; MSC-NC: mesenchymal stem cell carrying GFP; MSC-TGF-β1: TGF-β1 overexpressing MSC

Fig. 3F: Spleen: MSC-TGF-β1 was misplaced, and now corrected Effect of MSC-TGF-β1 on inflammatory cytokines in the plasma and macrophages in tissue. a, b, c: The levels of IL-6, IL-1β, and IL-10 in the plasma were tested by ELISA (n = 3, *p < 0.05 vs. the sham group; #p < 0.05 vs. the CLP group; &p < 0.05 vs. the MSC-NC group). d, e, f: The levels of macrophages in lung, liver and spleen tissue were assayed by immumohistochemical staining. (n = 3, *p < 0.05 vs. the sham group; #p < 0.05 vs. the CLP group; &p < 0.05 vs. the MSC-NC group). Scale bar = 100 μm. Abbreviations: CLP: cecal ligation and puncture; MSCs, mesenchymal stem cells; MSC-NC: mesenchymal stem cell carrying GFP; MSC-TGF-β1: TGF-β1 overexpressing MSC In the Materials and Methods section under the sub-heading “CLP model of sepsis”, the term, ‘5% chloral hydrate (400 mg/kg)’ should be pentobarbital (50 mg/kg), this can be seen in the first draft submitted to the journal. Correction made is listed below. The sepsis model was induced via the CLP method. Briefly, the mice were anaesthetized with pentobarbital (50 mg/kg) by intraperitoneal injection, and their lower abdomen was then shaved. In the section of ethics approval and consent to participate: All of the experimental procedures were approved by the Southeast University Ethics Committee (protocol number: 20171101006). These corrections will not affect the result and scientific conclusion of the manuscript. The authors would like to apologize for any inconvenience caused.
  1 in total

1.  Overexpressing TGF-β1 in mesenchymal stem cells attenuates organ dysfunction during CLP-induced septic mice by reducing macrophage-driven inflammation.

Authors:  Feng Liu; Jianfeng Xie; Xiwen Zhang; Zongsheng Wu; Shi Zhang; Ming Xue; Jianxiao Chen; Yi Yang; Haibo Qiu
Journal:  Stem Cell Res Ther       Date:  2020-09-03       Impact factor: 8.079

  1 in total

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