Literature DB >> 35896010

CAR T-cell Therapy Meets Clonal Hematopoiesis.

Ugur Uslu1, Carl H June1,2.   

Abstract

Clonal hematopoiesis of indeterminate potential (CHIP) is common in patients with hematologic malignancies. Recent publications provide evidence that CHIP may affect chimeric antigen receptor T-cell therapy efficacy and that the incidence of treatment-related toxicities such as cytokine release syndrome and immune effector-cell associated neurotoxicity syndrome may be affected. See related article by Saini et al., p. 385 (8). ©2022 American Association for Cancer Research.

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Year:  2022        PMID： 35896010      PMCID： PMC9445765          DOI： 10.1158/2643-3230.BCD-22-0067

Source DB:  PubMed          Journal:  Blood Cancer Discov        ISSN： 2643-3230


  15 in total

1.  Role of Donor Clonal Hematopoiesis in Allogeneic Hematopoietic Stem-Cell Transplantation.

Authors:  Mareike Frick; Willy Chan; Christopher Maximilian Arends; Raphael Hablesreiter; Adriane Halik; Michael Heuser; David Michonneau; Olga Blau; Kaja Hoyer; Friederike Christen; Joel Galan-Sousa; Daniel Noerenberg; Verena Wais; Michael Stadler; Kenichi Yoshida; Johannes Schetelig; Esther Schuler; Felicitas Thol; Emmanuelle Clappier; Maximilian Christopeit; Francis Ayuk; Martin Bornhäuser; Igor Wolfgang Blau; Seishi Ogawa; Tomasz Zemojtel; Armin Gerbitz; Eva M Wagner; Bernd M Spriewald; Hubert Schrezenmeier; Florian Kuchenbauer; Guido Kobbe; Markus Wiesneth; Michael Koldehoff; Gérard Socié; Nicolaus Kroeger; Lars Bullinger; Christian Thiede; Frederik Damm
Journal:  J Clin Oncol       Date:  2018-11-07       Impact factor: 44.544

Review 2.  Chimeric Antigen Receptor Therapy.

Authors:  Carl H June; Michel Sadelain
Journal:  N Engl J Med       Date:  2018-07-05       Impact factor: 91.245

3.  Age-related clonal hematopoiesis associated with adverse outcomes.

Authors:  Siddhartha Jaiswal; Pierre Fontanillas; Jason Flannick; Alisa Manning; Peter V Grauman; Brenton G Mar; R Coleman Lindsley; Craig H Mermel; Noel Burtt; Alejandro Chavez; John M Higgins; Vladislav Moltchanov; Frank C Kuo; Michael J Kluk; Brian Henderson; Leena Kinnunen; Heikki A Koistinen; Claes Ladenvall; Gad Getz; Adolfo Correa; Benjamin F Banahan; Stacey Gabriel; Sekar Kathiresan; Heather M Stringham; Mark I McCarthy; Michael Boehnke; Jaakko Tuomilehto; Christopher Haiman; Leif Groop; Gil Atzmon; James G Wilson; Donna Neuberg; David Altshuler; Benjamin L Ebert
Journal:  N Engl J Med       Date:  2014-11-26       Impact factor: 91.245

4.  Deleting DNMT3A in CAR T cells prevents exhaustion and enhances antitumor activity.

Authors:  Brooke Prinzing; Caitlin C Zebley; Christopher T Petersen; Yiping Fan; Alejandro Allo Anido; Zhongzhen Yi; Phuong Nguyen; Haley Houke; Matthew Bell; Dalia Haydar; Charmaine Brown; Shannon K Boi; Shanta Alli; Jeremy Chase Crawford; Janice M Riberdy; Jeoungeun J Park; Sheng Zhou; Mireya Paulina Velasquez; Chris DeRenzo; Cicera R Lazzarotto; Shengdar Q Tsai; Peter Vogel; Shondra M Pruett-Miller; Deanna M Langfitt; Stephen Gottschalk; Ben Youngblood; Giedre Krenciute
Journal:  Sci Transl Med       Date:  2021-11-17       Impact factor: 17.956

5.  Clonal Hematopoiesis Is Associated with Increased Risk of Severe Neurotoxicity in Axicabtagene Ciloleucel Therapy of Large B-Cell Lymphoma.

Authors:  Neeraj Y Saini; David M Swoboda; Uri Greenbaum; Junsheng Ma; Romil D Patel; Kartik Devashish; Kaberi Das; Mark R Tanner; Paolo Strati; Ranjit Nair; Luis Fayad; Sairah Ahmed; Hun Ju Lee; Swaminathan P Iyer; Raphael Steiner; Nitin Jain; Loretta Nastoupil; Sanam Loghavi; Guilin Tang; Roland L Bassett; Preetesh Jain; Michael Wang; Jason R Westin; Michael R Green; David A Sallman; Eric Padron; Marco L Davila; Frederick L Locke; Richard E Champlin; Guillermo Garcia-Manero; Elizabeth J Shpall; Partow Kebriaei; Christopher R Flowers; Michael D Jain; Feng Wang; Andrew P Futreal; Nancy Gillis; Sattva S Neelapu; Koichi Takahashi
Journal:  Blood Cancer Discov       Date:  2022-09-06

6.  Next-Generation CAR T-cell Therapies.

Authors:  Regina M Young; Nils W Engel; Ugur Uslu; Nils Wellhausen; Carl H June
Journal:  Cancer Discov       Date:  2022-07-06       Impact factor: 38.272

7.  Prevalence and variation of CHIP in patients with aggressive lymphomas undergoing CD19-directed CAR T-cell treatment.

Authors:  Raphael Teipel; Frank Kroschinsky; Michael Kramer; Theresa Kretschmann; Katharina Egger-Heidrich; Thomas Krüger; Leo Ruhnke; Sylvia Herold; Sebastian Stasik; Katja Sockel; Jan M Middeke; Karolin Trautmann-Grill; Martin Bornhäuser; Christian Thiede; Malte von Bonin
Journal:  Blood Adv       Date:  2022-03-22

8.  Donor clonal hematopoiesis increases risk of acute graft versus host disease after matched sibling transplantation.

Authors:  Betül Oran; Richard E Champlin; Feng Wang; Tomoyuki Tanaka; Rima M Saliba; Gheath Al-Atrash; Guillermo Garcia-Manero; Hagop Kantarjian; Kai Cao; Elizabeth J Shpall; Amin M Alousi; Rohtesh S Mehta; Uday Popat; Andy Futreal; Koichi Takahashi
Journal:  Leukemia       Date:  2021-06-16       Impact factor: 11.528

Review 9.  Clonal hematopoiesis and its emerging effects on cellular therapies.

Authors:  Malte von Bonin; Helena Klara Jambor; Raphael Teipel; Friedrich Stölzel; Christian Thiede; Frederik Damm; Frank Kroschinsky; Johannes Schetelig; Triantafyllos Chavakis; Martin Bornhäuser
Journal:  Leukemia       Date:  2021-07-02       Impact factor: 11.528

10.  Clonal hematopoiesis in patients receiving chimeric antigen receptor T-cell therapy.

Authors:  Peter G Miller; Adam S Sperling; Elliott J Brea; Mark B Leick; Geoffrey G Fell; Max Jan; Satyen H Gohil; Yu-Tzu Tai; Nikhil C Munshi; Catherine J Wu; Donna S Neuberg; Marcela V Maus; Caron Jacobson; Christopher J Gibson; Benjamin L Ebert
Journal:  Blood Adv       Date:  2021-08-10
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