| Literature DB >> 35895435 |
Khin S A Myint1, Arthur H P Mawuntu2, Sotianingsih Haryanto3,4, Darma Imran5, Sofiati Dian6, Yora P Dewi1, Ahmad R Ganiem6, Riane Anggreani2, Mirna M Iskandar3,4, Janno B B Bernadus2, Kartika Maharani5, David Susanto2, Riwanti Estiasari5, Hasna Dewi4, Amanda Kristiani7, Lidia Gaghiwu2, Edison Johar1, Frilasita A Yudhaputri1, Ungke Antonjaya1,8, Jeremy P Ledermann9, Reinout van Crevel10, Raph L Hamers8,11, Ann M Powers9.
Abstract
Chikungunya virus (CHIKV) is recognized but rarely considered as a cause of central nervous system infection in endemic areas. A total of 244 patients with acute meningoencephalitis in Indonesia were retrospectively tested to identify whether any CHIKV infection was associated with neurological manifestations, especially in provinces known for CHIKV endemicity. Cerebrospinal fluid and blood specimens were tested using CHIKV-specific real-time reverse transcription polymerase chain reaction and IgM ELISA, alongside a panel of neurotropic viruses. We report four cases of suspected or confirmed CHIKV-associated neurological disease, including CHIKV RNA detection in cerebrospinal fluid (CSF) of one patient and in acute serum of another, and CHIKV IgM in CSF of three patients and in serum of a fourth. In conclusion, CHIKV should be considered as a cause of neurologic disease in endemic areas and especially during outbreaks, in addition to the more common arboviral diseases such as dengue and Japanese encephalitis viruses.Entities:
Year: 2022 PMID： 35895435 PMCID： PMC9393428 DOI： 10.4269/ajtmh.22-0050
Source DB: PubMed Journal: Am J Trop Med Hyg ISSN： 0002-9637 Impact factor: 3.707