Rebecca A Chalmers1, Matti Cervin2, Carol Choo3, Bernhard T Baune4,5,6, Julian N Trollor7,8, Katya Numbers7, Perminder S Sachdev7,9, Henry Brodaty7, Nicole A Kochan7, Oleg N Medvedev10. 1. University of Waikato, Hamilton, New Zealand. 2. Lund University, Lund, Sweden. 3. College of Healthcare Sciences, Division of Tropical Health and Medicine, James Cook University, Townsville, QLD, Australia. 4. Department of Psychiatry, University of Muenster, Munster, Germany. 5. Department of Psychiatry, Melbourne Medical School, The University of Melbourne, Melbourne, VIC, Australia. 6. The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, Australia. 7. Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Sydney, Kensington, NSW, Australia. 8. Department of Developmental Disability Neuropsychiatry, School of Psychiatry, UNSW Sydney, Kensington, NSW, Australia. 9. Neuropsychiatric Institute, The Prince of Wales Hospital, Randwick, NSW, Australia. 10. University of Waikato, Hamilton, New Zealand. oleg.medvedev@waikato.ac.nz.
Abstract
BACKGROUND: Prioritizing the maintenance of healthy cognitive aging and personalizing preventive interventions to enhance their effectiveness is crucial as the global population ages. Systemic inflammation and depression in older people have been associated with decreased levels of cognition but results have been inconsistent. AIMS: To explore the interactive network of inflammation, depression and cognition by sex in older people. METHODS: We used novel network analysis to explore the unique associations between inflammatory biomarkers, depression, cognition, and somatic, genetic, and lifestyle risk factors in an older (aged 70-90 years), non-demented, community-dwelling sample from the longitudinal Sydney Memory and Aging Study (N = 916) at baseline and at a two-year follow-up. RESULTS: The networks of biomarkers, depression, cognition, and relevant covariates were significantly different between males and females. A stable negative link between depression and cognition was found in females only; a stable positive association between biomarker interleukin-6 and depression was found in females only; and a stable positive association between biomarker interleukin-8 and alcohol was found in females only. For both males and females, a stable, positive relationship was found between the presence of APOE-ε4 gene and biomarker C-reactive protein; between education and cognition; and between biomarker interleukin-6 and all other biomarkers. CONCLUSIONS: These findings suggest different psychophysiological mechanisms underlie the interactive network of biomarkers, depression and cognition in males and females that should be considered when designing personalized preventive interventions to maintain cognitively healthy aging.
BACKGROUND: Prioritizing the maintenance of healthy cognitive aging and personalizing preventive interventions to enhance their effectiveness is crucial as the global population ages. Systemic inflammation and depression in older people have been associated with decreased levels of cognition but results have been inconsistent. AIMS: To explore the interactive network of inflammation, depression and cognition by sex in older people. METHODS: We used novel network analysis to explore the unique associations between inflammatory biomarkers, depression, cognition, and somatic, genetic, and lifestyle risk factors in an older (aged 70-90 years), non-demented, community-dwelling sample from the longitudinal Sydney Memory and Aging Study (N = 916) at baseline and at a two-year follow-up. RESULTS: The networks of biomarkers, depression, cognition, and relevant covariates were significantly different between males and females. A stable negative link between depression and cognition was found in females only; a stable positive association between biomarker interleukin-6 and depression was found in females only; and a stable positive association between biomarker interleukin-8 and alcohol was found in females only. For both males and females, a stable, positive relationship was found between the presence of APOE-ε4 gene and biomarker C-reactive protein; between education and cognition; and between biomarker interleukin-6 and all other biomarkers. CONCLUSIONS: These findings suggest different psychophysiological mechanisms underlie the interactive network of biomarkers, depression and cognition in males and females that should be considered when designing personalized preventive interventions to maintain cognitively healthy aging.
Authors: C Franceschi; M Bonafè; S Valensin; F Olivieri; M De Luca; E Ottaviani; G De Benedictis Journal: Ann N Y Acad Sci Date: 2000-06 Impact factor: 5.691
Authors: B T Baune; E Smith; S Reppermund; T Air; K Samaras; O Lux; H Brodaty; P Sachdev; J N Trollor Journal: Psychoneuroendocrinology Date: 2012-03-09 Impact factor: 4.905
Authors: Di Qi; Nichol M L Wong; Robin Shao; Idy S C Man; Clive H Y Wong; Lai Ping Yuen; Chetwyn C H Chan; Tatia M C Lee Journal: Brain Behav Immun Date: 2021-04-16 Impact factor: 7.217
Authors: Julian N Trollor; Evelyn Smith; Emmeline Agars; Stacey A Kuan; Bernhard T Baune; Lesley Campbell; Katherine Samaras; John Crawford; Ora Lux; Nicole A Kochan; Henry Brodaty; Perminder Sachdev Journal: Age (Dordr) Date: 2011-08-19
Authors: Mario Maj; Dan J Stein; Gordon Parker; Mark Zimmerman; Giovanni A Fava; Marc De Hert; Koen Demyttenaere; Roger S McIntyre; Thomas Widiger; Hans-Ulrich Wittchen Journal: World Psychiatry Date: 2020-10 Impact factor: 49.548