| Literature DB >> 35892516 |
Gerhard Grobler1,2, Werdie Van Staden2.
Abstract
The challenges in assessing whether psychiatric treatment should be provided on voluntary, assisted or involuntary legal bases prompted the development of an assessment algorithm that may aid clinicians. It comprises a part that assesses the incapacity to provide informed consent to treatment, care or rehabilitation. It also captures the patient's willingness to receive these treatments, the risk posed to the patient's health or safety, financial interests or reputation and risks of serious harm to self or others. By following various decision paths, the algorithm yields one of four legal states: a voluntary, assisted, or involuntary state or that the proposed intervention should be declined. This study examined the predictive validity and the reliability of this algorithm. It was applied 4052 times to 135 clinical case narratives by 294 research participants. The legal states yielded by the algorithm had high statistical significance when matched with the gold standard (Chi-squared = 6963; df = 12; p < 0.001). It was accurate in yielding the correct legal state for the voluntary, assisted, involuntary and decline categories in 94%, 92%, 88% and 86% of the clinical case narratives, respectively. For internal reliability, a correspondence model accounted for 99.8% of the variance by which the decision paths clustered together fittingly with each of the legal states. Inter-rater reliability testing showed a moderate degree of agreement among participants on the suitable legal state (Krippendorff's alpha = 0.66). These results suggest the algorithm is valid and reliable, which warrant a subsequent randomised controlled study to investigate whether it is more effective in clinical practice than standard assessments.Entities:
Keywords: algorithms; decision support techniques; informed consent; medical legislation; mental capacity; mental incompetence
Year: 2022 PMID: 35892516 PMCID: PMC9330761 DOI: 10.3390/diagnostics12081806
Source DB: PubMed Journal: Diagnostics (Basel) ISSN: 2075-4418
Gold standard legal states of the case narratives and mean number of participants applying the ILSAA per case narrative.
| Gold Standard Legal State | Number of Case Narratives | Mean Number of Participants Applying the ILSAA Per Case Narrative |
|---|---|---|
| Voluntary | 37 | 35.5 (standard deviation = 6.6) |
| Involuntary | 33 | 31.9 (standard deviation = 8.8) |
| Assisted | 32 | 33.8 (standard deviation = 8.6 |
| Decline | 29 | 21.0 (standard deviation = 10.2) |
Standardised residuals comparing the legal states yielded by the ILSAA outcomes to the gold standard legal states.
| Legal State | ILSAA Outcomes | Total | |||||
|---|---|---|---|---|---|---|---|
| Assisted | Declined | Involuntary | Voluntary | ||||
| Gold | Assisted | Count | 894 | 23 | 124 | 38 | 1081 |
| Expected count | 272.4 | 154.7 | 318.8 | 334 | 1081 | ||
| Standardised | 37.7 | −10.6 | −10.9 | −16.2 | |||
| Declined | Count | 36 | 383 | 134 | 56 | 609 | |
| Expected count | 153.5 | 87.2 | 179.6 | 188.2 | 609 | ||
| Standardised | −9.5 | 31.7 | −3.4 | −9.6 | |||
| Involuntary | Count | 35 | 80 | 933 | 2 | 1051 | |
| Expected count | 264.8 | 150.4 | 310 | 324.7 | 1051 | ||
| Standardised | −14.1 | −5.7 | 35.4 | −17.9 | |||
| Voluntary | Count | 56 | 94 | 4 | 1156 | 1311 | |
| Expected count | 330.3 | 187.7 | 386.6 | 405.1 | 1311 | ||
| Standardised | −15.1 | −6.8 | −19.5 | 37.3 | |||
True Positive, False Positive, True Negative and False Negative values 1.
| Voluntary | Assisted | Involuntary | Declined | |
|---|---|---|---|---|
| True Positive | 33 | 26 | 29 | 17 |
| False Negative | 4 | 6 | 4 | 12 |
| False Positive | 4 | 5 | 11 | 6 |
| True Negative | 90 | 94 | 87 | 96 |
| Total | 131 | 131 | 131 | 131 |
1 Participants contributed to a composite value for each clinical case narrative.
Predictive validity calculations.
| Voluntary | Assisted | Involuntary | Declined | |
|---|---|---|---|---|
| Predictive Accuracy | 94% | 92% | 88% | 86% |
| Sensitivity | 89% | 82% | 87% | 59% |
| Specificity | 96% | 95% | 89% | 94% |
| Positive Predictive Value | 89% | 84% | 72% | 74% |
| Negative Predictive Value | 95% | 94% | 95% | 89% |
| False Negative Rate | 11% | 18% | 13% | 41% |
| False Positive rate | 4% | 5% | 11% | 6% |
Pearson’s correlation coefficients for associations between the clinical features and case-specific accuracy.
| Case-Specific Accuracy% | Suicidality Features | Incongruence in Symptom Severity | Incongruence in Severity of Suicide Risk | Cognitive Impairment | Psychotic Features | |
|---|---|---|---|---|---|---|
| Case-specific Accuracy% | 1 | −0.033 | −0.170 | −0.134 | 0.204 | 0.208 |
| Suicidality features | −0.033 | 1 | −0.502 | 0.440 | 0.002 | v0.034 |
| Incongruence in symptom severity | −0.170 | −0.502 | 1 | −0.257 | −0.171 | −0.143 |
| Incongruence in severity of suicide risk | −0.134 | 0.440 | −0.257 | 1 | −0.184 | −0.133 |
| Cognitive impairment | 0.204 | 0.002 | −0.171 | −0.184 | 1 | 0.026 |
| Psychotic feature | 0.208 | −0.034 | −0.143 | −0.133 | 0.026 | 1 |
Scores of the legal states and decision paths in the correspondence analysis 1.
| Legal States | Mass | Score in Dimension 1 | Score in Dimension 2 | ||
|---|---|---|---|---|---|
| Legal state | Decision path | Legal state | Decision path | ||
| Assisted | 0.252 | 0.408 | 0.409 | 1.265 | 1.271 |
| Declined | 0.144 | 1.679 | 1.685 | −1.708 | −1.717 |
| Involuntary | 0.295 | 0.215 | 0.216 | 0.414 | 0.416 |
| Voluntary | 0.310 | −1.315 | −1.320 | −0.629 | −0.632 |
| Total | 1.001 | ||||
1 Symmetric normalisation was applied.
Figure 1Correspondence model between legal states and decision paths.
Krippendorff’s alpha values for the legal states and the decision paths.
| Consistency Parameter | Participants | Alpha | Bootstrapped Alpha Coefficient | 95% Confidence Interval |
|---|---|---|---|---|
| Legal states | All participants | 0.650 | 0.663 | 0.634–0.693 |
| General physicians-in-training | 0.653 | 0.666 | 0.637–0.694 | |
| Psychiatrists-in-training | 0.644 | 0.855 | 0.754–0.952 | |
| Decision paths | All participants | 0.426 | 0.447 | 0.424–0.471 |
| General physicians-in-training | 0.430 | 0.451 | 0.426–0.477 | |
| Psychiatrists-in-training | 0.417 | 0.764 | 0.623–0.899 |