| Literature DB >> 3589148 |
N Soni, K Pande, R Kalsi, T K Gupta, S S Parmar, J P Barthwal.
Abstract
Substituted 1,5-diaryl-3(4-chlorophenyl)-delta 2-pyrazolines were synthesized and evaluated for anticonvulsant activity. Most pyrazolines (100 mg/kg) provided 20-80% protection against pentylenetetrazol-induced convulsions in mice. All compounds inhibited rat brain mitochondrial monoamine oxidase (MAO) and succinic dehydrogenase (SDH) and exhibited low toxicity as reflected by approximate LD50 values (500 to greater than 1000 mg/kg) in mice.Entities:
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Year: 1987 PMID： 3589148
Source DB: PubMed Journal: Res Commun Chem Pathol Pharmacol ISSN： 0034-5164